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Natural products show promise against COVID-19 via iron chelation

Researchers at the University of Catania in Italy investigated whether natural compounds could prevent disease progression. Their study published in the Journal of Clinical Medicine found that iron chelators and protease inhibitors can counteract SARS-CoV-2 infection.

7 Jun 2021

Study observes broad and invariable memory B cell response following SARS-CoV-2 infection

A new study by researchers at the Oregon Health & Science University (OHSU) in the USA goes far in answering this question by showing the presence of memory B cells that react to the original SARS-CoV-2 as well as VOCs.

7 Jun 2021

MRI-guided focused ultrasound advances brain and cancer research

By 2034, nearly one-quarter of Americans will have reached retirement age, according to the United States Census Bureau. But as people age, the brain becomes more susceptible to developing disorders, such as essential tremor, Parkinson's disease, and tumors.

7 Jun 2021

World Health Organization simplifies names of SARS-CoV-2 variants

Now, the World Health Organization (WHO) has assigned simple and easy-to-say labels for key variants of SARS-CoV-2 using letters of the Greek alphabet. The health agency selected these labels after a thorough review of many potential naming systems.

4 Jun 2021

Study: Nasal therapy is more effective than commonly used IgG antibodies at neutralizing COVID-19 virus

A nasal therapy, built upon on the application of a new engineered IgM antibody therapy for COVID-19, was more effective than commonly used IgG antibodies at neutralizing the COVID-19 virus in animal models, according to research recently published by The University of Texas Health Science Center at Houston (UTHealth), The University of Texas Medical Branch at Galveston (UTMB Health), the University of Houston, and IGM Biosciences, Inc.

4 Jun 2021

Researchers develop rapid antibody screening method for novel COVID-19 therapeutics development

New research undertaken by researchers in the USA describes two parallel but distinct in vivo approaches for the accelerated discovery of antibodies targeting SARS-CoV-2 spike protein.

3 Jun 2021

SARS-CoV-2 exploits metal-dependent mechanism to evade immune surveillance

Scientists from The University of Texas Health Science Center at San Antonio have discovered a mechanism by which SARS-CoV-2 exploits changes in metal ion concentrations to disguise itself in the body. Varying concentrations of metal ions -- positively charged atoms such as magnesium, manganese and calcium -- are observed in hospitalized COVID-19 patients.

3 Jun 2021

Centivax and US Naval Medical Research Center to begin Phase I clinical trial of antibody therapeutics

Centivax Inc. announced today that it has entered into a strategic partnership with the U.S. Naval Medical Research Center (NMRC) for Phase I clinical development of Centi-B9, Centivax's SARS-CoV-2 broad-spectrum injectable antibody therapeutic and prophylactic.

3 Jun 2021

E6-specific inhibitors offer a unique, strategic approach for treating HPV-HNSCC

Oncotarget published "A high-content AlphaScreen™ identifies E6-specific small molecule inhibitors as potential therapeutics for HPV+ head and neck squamous cell carcinomas" which reported that the incidence of human papillomavirus-positive head and neck squamous cell carcinoma has increased dramatically over the past decades due to an increase in infection of the oral mucosa by HPV.

3 Jun 2021

Sinai Health researchers provide an ultra-detailed look at the organization of human cells

Researchers from Sinai Health have published a study providing an ultra-detailed look at the organization of a living human cell, providing a new tool that can help scientists around the world better understand what happens during disease.

2 Jun 2021

Study uncovers mechanisms by which microRNAs drive atherogenesis in a cell-type-specific manner

Researchers at the University of Eastern Finland have uncovered potential mechanisms by which microRNAs (miRNA) drive atherogenesis in a cell-type-specific manner.

2 Jun 2021

Cmed Technology Adds More Capabilities to its Encapsia Platform and Reports Increased Demand for Use in Decentralized Trials (DCT)

Innovative technology for clinical trials is now, more than ever, necessary to deliver decentralized trials (DCT) and enable design of hybrid protocols that support trial continuity and patient-centricity.

2 Jun 2021

Aptamer Group and PinotBio collaborate to develop new therapeutic drug conjugates

Aptamer Group Limited and PinotBio today announce that they have entered into a strategic collaboration agreement.

From Aptamer Group 2 Jun 2021

Researchers identify new approach to clear toxic Huntingtin protein

Researchers world-wide are focused on clearing the toxic mutant Huntingtin protein that leads to neuronal cell death and systemic dysfunction in Huntington's disease (HD), a devastating, incurable, progressive neurodegenerative genetic disorder.

2 Jun 2021

Depleting SIRPα-deficient in macrophages activate tumor antigen-specific cytotoxic T cells

In a study that will be published in Nature Communications on May 28, 2021, a research team led by Dr. Yuan Liu from Georgia State University reports that intratumoral SIRPα-deficient macrophages activate tumor antigen-specific cytotoxic T cells to eliminate various syngeneic cancers under radiotherapy.

2 Jun 2021

Novel antibody engineering approach

Scientists from the Johns Hopkins University School of Medicine, USA, have recently developed an Antibody Display technology by grafting the second extracellular domain of tetraspanin12 (Tspan12EC2) and the receptor-binding domain (RBD) of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein on the heavy chain complementarity-determining region 3 (CDR3).

2 Jun 2021

Molecular subtype of cancer preferentially affects people with Indigenous ancestry

Oncotarget published "Global DNA hypermethylation pattern and unique gene expression signature in liver cancer from patients with Indigenous American ancestry" which reported that contrasting with this pattern, the age structure of HCC in Andean people displays a bimodal distribution with half of the patients developing HCC in adolescence and early adulthood.

2 Jun 2021

Researchers identify kite-shaped molecules that block SARS-CoV-2 cell entry after attachment

They have identified a group of kite-shaped compounds that are highly specific to SARS-CoV-1 and SARS-CoV-2. These compounds demonstrate high potency in inhibiting SARS-CoV-2 infection at early entry steps. The study is currently available on the bioRxiv* preprint server.

2 Jun 2021

Scientists use an original approach to resolve the 3D structure of flaviviruses

In a recent study, Australian scientists used an original approach to resolve the 3D structure of flaviviruses with an unprecedented level of detail, identifying small molecules known as 'pocket factors' as new therapeutic targets.

1 Jun 2021

Researchers identify common epitopes across SARS-CoV-2 viral variants

While several COVID-19 vaccine candidates have been developed and deployed to arrest the spread of SARS-CoV-2, concern among scientists and public health authorities is mounting over the immunity escape potential of emerging viral variants. To address this problem, a group of scientists in Germany has undertaken research to identify molecular targets across viral variants to aid in the development of second and third-generation vaccines and novel therapeutics.

1 Jun 2021

Therapeutics News and Research

Natural products show promise against COVID-19 via iron chelation

Study observes broad and invariable memory B cell response following SARS-CoV-2 infection

MRI-guided focused ultrasound advances brain and cancer research

World Health Organization simplifies names of SARS-CoV-2 variants

Study: Nasal therapy is more effective than commonly used IgG antibodies at neutralizing COVID-19 virus

Researchers develop rapid antibody screening method for novel COVID-19 therapeutics development

SARS-CoV-2 exploits metal-dependent mechanism to evade immune surveillance

Centivax and US Naval Medical Research Center to begin Phase I clinical trial of antibody therapeutics

E6-specific inhibitors offer a unique, strategic approach for treating HPV-HNSCC

Sinai Health researchers provide an ultra-detailed look at the organization of human cells

Study uncovers mechanisms by which microRNAs drive atherogenesis in a cell-type-specific manner

Cmed Technology Adds More Capabilities to its Encapsia Platform and Reports Increased Demand for Use in Decentralized Trials (DCT)

Aptamer Group and PinotBio collaborate to develop new therapeutic drug conjugates

Researchers identify new approach to clear toxic Huntingtin protein

Depleting SIRPα-deficient in macrophages activate tumor antigen-specific cytotoxic T cells

Novel antibody engineering approach

Molecular subtype of cancer preferentially affects people with Indigenous ancestry

Researchers identify kite-shaped molecules that block SARS-CoV-2 cell entry after attachment

Scientists use an original approach to resolve the 3D structure of flaviviruses

Researchers identify common epitopes across SARS-CoV-2 viral variants

Industry Focus eBook - Cell biology (5th edition) eBook

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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