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Innovative approach for identifying new molecules to help track progression of Parkinson's

For many of the 200,000 patients diagnosed with Parkinson's disease in the United States every year, the diagnosis often occurs only after the appearance of severe symptoms such as tremors or speech difficulties.

21 Sep 2020

Research uncovers potential cause of neurotoxicity due to immunotherapy

New research has uncovered the previously unknown presence of CD19 -- a B cell molecule targeted by chimeric antigen receptor (CAR) T cell immunotherapy to treat leukemia, lymphoma, and multiple myeloma -- in brain cells that protect the blood brain barrier (BBB).

21 Sep 2020

Psoriatic arthritis may be activated by the same trigger in different patients, study reveals

A new study has revealed psoriatic arthritis may be activated by the same trigger in different patients. Researchers from the University of Oxford and the Wellcome Sanger Institute identified high levels of a specific receptor in immune cells from psoriatic arthritis patients, giving the strongest evidence yet of a single cause for the disease

21 Sep 2020

Researchers identify a compound that inhibits growth of schwannomas

Schwannomas are tumors of the peripheral nervous system, which often occur in the genetic disease neurofibromatosis type 2. The research group of Prof. Dr. Helen Morrison at the Leibniz Institute on Aging - Fritz Lipmann Institute in Jena, Germany, identified a compound that inhibits the growth of such tumors and improves nerve function.

21 Sep 2020

Soluble ACE2 microbody blocks SARS-CoV-2 entry into lung cells

A new study by researchers at NYU Langone Medical Center and Weill Cornell Medical College and published on the preprint server bioRxiv* in September 2020 reports the potential of an angiotensin-converting enzyme 2 (ACE2)-antibody Fc complex in a new format that seems to offer more significant inhibition of SARS-CoV-2.

21 Sep 2020

KRASG12C inhibitor sotorasib shows durable clinical benefits for solid cancers

In a Phase I clinical trial for patients with advanced solid cancers marked by KRAS G12C mutations, the KRASG12C inhibitor sotorasib (AMG 510) resulted in manageable toxicities and durable clinical benefits.

21 Sep 2020

SARS-CoV-2 infects monocytes and macrophages, without cytopathic effect

A team of researchers from Aix-Marseille Univ, IHU-Méditerranée Infection, Institut Paoli Calmettes and Laboratoire d’Immunologie, Marseille, France, conducted experiments to determine if SARS-CoV-2 can affect the myeloid compartment or infect monocytes and macrophages.

20 Sep 2020

Discovery could help enhance the effectiveness of immunotherapy against melanoma

Researchers at the University of Bern have discovered a mechanism in the body’s own immune system which is responsible for the maturation and activation of immune cells.

19 Sep 2020

Cellular recyclers could be used to eliminate the driver of cancer's aggressiveness

"Do not erase." "Recycle me." "Free to a good home." Humans post these signs to indicate whether something has value or not, whether it should be disposed of or not.

18 Sep 2020

Molecular imaging probe reveals Alzheimer's-related γ-secretase in rodents, macaques

Scientists at the Massachusetts General Hospital (MGH) have developed a molecular imaging probe to reveal Alzheimer's disease (AD)-related γ-secretase in rodents and macaques with translational potentials in humans.

18 Sep 2020

Researchers describe details of protein linked to genetically inherited Parkinson's disease

In August, a team of researchers at the University of California San Diego published groundbreaking back-to-back studies describing unprecedented details of a protein linked to genetically inherited Parkinson's disease.

18 Sep 2020

Australian stinging tree could pave way for novel painkillers

Australia is well known for having many of the world's most venomous creatures, ranging from snakes, spiders, jellyfish, centipedes, fish, ticks, bees, and ants. 21 of the 25 most venomous snakes in the world are all from Australia. The country is also home to dangerous plants, like the Australian stinging tree.

17 Sep 2020

New drug candidate suppresses SARS-CoV-2 replication

Researchers at Stanford University and Utah State University have developed a novel inhibitor of the coronavirus main protease (Mpro) that effectively suppresses the viral replication of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

17 Sep 2020

Smart drug delivery system may help treat spinal cord injuries, neurological disorders

A Rutgers-led team has created a smart drug delivery system that reduces inflammation in damaged nervous tissues and may help treat spinal cord injuries and other neurological disorders.

17 Sep 2020

Ceftazidime flagged as a potential inhibitor of the SARS-COV-2 virus

After screening more than 3,500 FDA-approved drugs and small molecules, researchers at the Chinese Academy of Sciences found that ceftazidime, an antibiotic approved for use in treating pneumonia, binds to the receptors that the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) binds to in human cells.

17 Sep 2020

Study provides new insight into the evolution of limb regeneration in lungfish and other species

For most vertebrates, losing a limb is permanent, but a lucky few species -- such as salamanders and tadpoles -- have the ability to completely regrow complex body parts.

17 Sep 2020

Powerful 2D FFF system opens up new routes for separations

Postnova Analytics powerful EAF4 technology combines the principle of Electrical and Asymmetrical Flow Field-Flow Fractionation in just one system.

From Postnova Analytics 17 Sep 2020

Anti-CD73 molecule CPI-006 activates B cell responses to SARS-CoV-2

As the COVID-19 pandemic continues to cause an immense impact across many parts of the world, the role played by immune responses is becoming more evident every day. A recent funded paper published on the preprint server medRxiv* in September 2020 reports the initiation of a Phase I trial of a drug that increases antibody and cell-mediated immune responses against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

17 Sep 2020

Study shows how the body's immune system finds intruding or damaged cells

Research led by Dr. Wonmuk Hwang has led to better understanding on how components of the body's immune system find intruding or damaged cells, which could lead to novel approaches to viral and cancer treatments.

17 Sep 2020

Candidate monoclonal antibody shows hope as COVID-19 treatment

Researchers in the United States have described the effectiveness of a candidate monoclonal antibody currently being evaluated in a Phase 1 trial as a therapy for coronavirus disease 2019 (COVID-19) and its causative agent, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

16 Sep 2020

Molecule News and Research

Innovative approach for identifying new molecules to help track progression of Parkinson's

Research uncovers potential cause of neurotoxicity due to immunotherapy

Psoriatic arthritis may be activated by the same trigger in different patients, study reveals

Researchers identify a compound that inhibits growth of schwannomas

Soluble ACE2 microbody blocks SARS-CoV-2 entry into lung cells

KRASG12C inhibitor sotorasib shows durable clinical benefits for solid cancers

SARS-CoV-2 infects monocytes and macrophages, without cytopathic effect

Discovery could help enhance the effectiveness of immunotherapy against melanoma

Cellular recyclers could be used to eliminate the driver of cancer's aggressiveness

Molecular imaging probe reveals Alzheimer's-related γ-secretase in rodents, macaques

Researchers describe details of protein linked to genetically inherited Parkinson's disease

Australian stinging tree could pave way for novel painkillers

New drug candidate suppresses SARS-CoV-2 replication

Smart drug delivery system may help treat spinal cord injuries, neurological disorders

Ceftazidime flagged as a potential inhibitor of the SARS-COV-2 virus

Study provides new insight into the evolution of limb regeneration in lungfish and other species

Powerful 2D FFF system opens up new routes for separations

Anti-CD73 molecule CPI-006 activates B cell responses to SARS-CoV-2

Study shows how the body's immune system finds intruding or damaged cells

Candidate monoclonal antibody shows hope as COVID-19 treatment

Industry Focus eBook - Analytical Chemistry (2nd Edition) eBook

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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