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Chimeric Delta-Omicron RBD-dimer vaccine found to be effective against SARS-CoV-2 variants

In a new study, researchers described their self-designed chimeric receptor-binding domain-dimer vaccine approach to adapt SARS-CoV-2 variants of concern and variants of interest.

29 Apr 2022

Understanding sex differences in the pathophysiology of SARS-CoV-2 infection

A recent study published in the journal Immunology analyzed whether sex mattered in the immune response to SARS-CoV-2.

29 Apr 2022

Study finds curcumin is a potential therapeutic agent against the Omicron variant of SARS-CoV-2

A recent study demonstrated that the phytochemical curcumin is a potent therapeutic prospect against the SARS-CoV-2 Omicron variant

29 Apr 2022

Study shows polysaccharides of seaweed and abalone inhibit SARS-CoV-2 in vitro

A new study published in Marine Drugs evaluated the inhibitory effect of three polysaccharides, crude polysaccharide from Hizikia fusiforme (CPHF), crude polysaccharide from Sargassum horneri (CPSH), and crude polysaccharide from abalone viscera (CPAV) on the propagation of SARS-CoV-2 in vitro.

28 Apr 2022

Genetic bottlenecks could impact Wyoming toads' ability to respond to new pathogens

A new study from North Carolina State University examines immune system diversity in the critically endangered Wyoming toad and finds that genetic bottlenecks could impact a species' ability to respond to new pathogens.

28 Apr 2022

Scientists identify the neural basis of pleasant touch sensation

Studying mice, scientists at Washington University School of Medicine in St. Louis have identified a neural circuit and a neuropeptide - a chemical messenger that carries signals between nerve cells - that transmit the sensation known as pleasant touch from the skin to the brain.

28 Apr 2022

Novel method could bring life-saving benefits of CAR T-cell therapy to patients with acute myeloid leukemia

Massachusetts General Hospital researchers have developed a novel treatment strategy that has the potential to bring the life-saving benefits of chimeric antigen receptor T-cell therapy (CAR T) to patients with acute myeloid leukemia (AML) the most common form of leukemia in adults.

28 Apr 2022

Therapeutic promise of CAR-T cell bispecific engagers against SARS-CoV-2

A new paper describes a novel method, using a specific molecule to engage T cell receptors and the virus receptor, the angiotensin-converting enzyme 2, at the same time.

28 Apr 2022

Review aims to deepen the understanding of the role of natural killer cells in COVID-19

In a recent study published in Biomedicines, researchers explored the utility of natural killer (NK) cells in coronavirus disease 2019 (COVID-19).

28 Apr 2022

Exploring oncolytic viral therapeutics and immunotherapies derived from DNA and RNA

A new review initially described the developments in cancer-based medicines that included vaccinations, vector-based techniques, and genome injection using DNA and RNA-based nucleic acid therapeutics.

28 Apr 2022

Identification of a SARS-CoV-2 neutralizing human monoclonal antibody with a remarkable broad-spectrum neutralization and protection efficacy

Researchers identified a human monoclonal antibody (mAb), 87G7, with in vitro neutralizing activity against several SARS-CoV-2 VOCs, including Alpha, Beta, Gamma, Delta, and Omicron.

28 Apr 2022

A cigarette smoke compound affects cartilage homeostasis

Cigarette smoke has been shown to deleteriously affect human health. For example, degenerative disc diseases are increasingly linked to cigarette smoking.

28 Apr 2022

MAPK pathway mutations can provide “precision” treatment targets for head and neck cancer

About one-fifth of often deadly head and neck cancers harbor genetic mutations in a pathway that is key to normal cell growth, and scientists report those mutations, which enable abnormal cancer cell growth, can also make the cancer vulnerable.

28 Apr 2022

Researchers unravel why neuropsychiatric symptoms appear in Alzheimer's patients before memory loss

Researchers from Indiana University School of Medicine are studying why neuropsychiatric symptoms, such as apathy and irritability, appear in most Alzheimer's disease patients before the onset of memory loss.

28 Apr 2022

Discovery of novel antibody that targets shared epitope on SARS-CoV-2 variants

Researchers assessed the antibody responses elicited by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants and defined the epitopes shared by them.

28 Apr 2022

Study illuminates why cowpea mosaic virus is exceptionally effective against cancer

A plant virus that infects legumes, called cowpea mosaic virus, has a special power that you may not have known about: when injected into a tumor, it triggers the immune system to treat the cancer - even metastatic cancer - and prevents it from recurring.

27 Apr 2022

Study describes ultra-structure of Nipah virus surface glycoprotein

A team of US-based scientists has recently demonstrated the cryo-electron microscopic structure and antigenicity of the attachment glycoprotein of the Nipah virus.

27 Apr 2022

Research reveals a therapeutic opportunity to prevent rhabdomyosarcoma recurrence

Rhabdomyosarcoma is a type of soft tissue cancer. Scientists at St. Jude Children's Research Hospital studied the population of cells that persists after therapy, causing rhabdomyosarcoma recurrence.

27 Apr 2022

Does re-freezing COVID-19 mRNA vaccines affect immunogenicity?

A new study published in the journal Vaccines evaluated if re-freezing coronavirus disease 2019 (COVID-19) mRNA vaccine vials preserved the immunogenicity.

27 Apr 2022

Penn scientists discover how one inflammatory disorder increases susceptibility to another

The immune system remembers. Often this memory, primed by past encounters with threats like bacteria or viruses, is an asset. But when that memory is sparked by internal drivers, like chronic inflammation, it can prove detrimental, perpetuating a misguided immune response.

27 Apr 2022

Receptor News and Research

Chimeric Delta-Omicron RBD-dimer vaccine found to be effective against SARS-CoV-2 variants

Understanding sex differences in the pathophysiology of SARS-CoV-2 infection

Study finds curcumin is a potential therapeutic agent against the Omicron variant of SARS-CoV-2

Study shows polysaccharides of seaweed and abalone inhibit SARS-CoV-2 in vitro

Genetic bottlenecks could impact Wyoming toads' ability to respond to new pathogens

Scientists identify the neural basis of pleasant touch sensation

Novel method could bring life-saving benefits of CAR T-cell therapy to patients with acute myeloid leukemia

Therapeutic promise of CAR-T cell bispecific engagers against SARS-CoV-2

Review aims to deepen the understanding of the role of natural killer cells in COVID-19

Exploring oncolytic viral therapeutics and immunotherapies derived from DNA and RNA

Identification of a SARS-CoV-2 neutralizing human monoclonal antibody with a remarkable broad-spectrum neutralization and protection efficacy

A cigarette smoke compound affects cartilage homeostasis

MAPK pathway mutations can provide “precision” treatment targets for head and neck cancer

Researchers unravel why neuropsychiatric symptoms appear in Alzheimer's patients before memory loss

Discovery of novel antibody that targets shared epitope on SARS-CoV-2 variants

Study illuminates why cowpea mosaic virus is exceptionally effective against cancer

Study describes ultra-structure of Nipah virus surface glycoprotein

Research reveals a therapeutic opportunity to prevent rhabdomyosarcoma recurrence

Does re-freezing COVID-19 mRNA vaccines affect immunogenicity?

Penn scientists discover how one inflammatory disorder increases susceptibility to another

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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