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Experimental gene therapy restores immune system function in children with genetic immune disorder

An experimental gene therapy developed by researchers at UCLA, University College London and Great Ormond Street Hospital has restored and maintained immune system function in 59 of 62 children born with ADA-SCID, a rare and deadly genetic immune disorder.

15 Oct 2025

Gene therapy shows long-term success in children with rare immune disorder

Results from the largest cohort of children who received a gene therapy for a rare immunodeficiency condition have shown the long-term safety and efficacy of the curative treatment, in a study led by a UCL researcher.

15 Oct 2025

What happens when microplastics reach the testes? Study shows autophagy and cell loss

Researchers found that microplastics from everyday plastic tableware accumulate in human semen and, although not linked to semen quality in the full cohort, were associated with altered sperm parameters in specific subgroups. Experimental models confirmed that 50 nm polystyrene particles trigger autophagy and apoptosis via the FOXA1/MAP3K1/p38 pathway, impairing sperm structure and function.

15 Oct 2025

New research aims to develop targeted therapy for hard-to-treat osteosarcoma

For children and young adults diagnosed with osteosarcoma, a common type of bone cancer for that age group, the odds of survival can be devastatingly low (20-30%) when the disease spreads to the lungs.

15 Oct 2025

Combination therapy shows promising results in patients with rare subtype of non-Hodgkin lymphoma

Combining an epigenetic therapy with an anti-PD-1 antibody, which uses the body's natural response to viral infections, showed promising results in patients with relapsed or refractory natural killer/T-cell lymphoma (R/R NKTL), a rare and aggressive cancer with limited treatment options.

15 Oct 2025

New wearable sensor tracks vitamin B6 levels in sweat

Vitamin B6, which is absorbed from a broad range of foods, helps bolster immune system function and neurotransmitters in the brain.

14 Oct 2025

Estradiol and estriol may protect nerve function in multiple sclerosis

About 100,000 of the estimated million people in the United States with multiple sclerosis (MS) have a progressive form of the disease, with symptoms that worsen continuously or after periods of remission.

14 Oct 2025

Discovery of CPD gene mutations sheds light on rare congenital hearing loss

Mutations in a gene known as CPD play a crucial role in a rare form of congenital hearing loss, an international team of researchers has discovered.

14 Oct 2025

Targeting the glycocalyx may offer a new approach to reduce frailty in older adults

A new research paper was published in Volume 17, Issue 9 of Aging-US on August 30, 2025, titled, "Glycocalyx-targeted therapy prevents age-related muscle loss and declines in maximal exercise capacity."

14 Oct 2025

Study uncovers key protein complex controlling sperm motility and male fertility

Infertility affects about one in six couples, and male factors account for roughly half of all cases-often because sperm don't swim well.

13 Oct 2025

Engineered antibody triggers powerful anti-tumor response in advanced cancers

Many advanced cancers develop resistance to treatment and become highly aggressive, often leaving patients with limited treatment options.

13 Oct 2025

Targeting aggressive childhood leukemia with nanobody PROTACs

Scientists at the University of Duisburg-Essen are researching new therapies for aggressive forms of childhood leukemia.

13 Oct 2025

New insights into sperm metabolism could transform infertility treatments

Michigan State University scientists have pinpointed the molecular "switch" that supercharges sperm for their final sprint to an egg - a breakthrough that could reshape infertility treatments and pave the way for safe, nonhormonal male contraceptives.

10 Oct 2025

Advances in nanomaterials revolutionize therapy for myocardial ischemia-reperfusion injury

Ischemic heart disease is the leading cause of death globally, causing approximately 9 million deaths annually.

10 Oct 2025

Evolutionary mutation in cGAS enhances naked mole-rat DNA repair

The secret to the naked mole-rats' extraordinarily long life may lie in subtle changes to just four amino acids, researchers report. According to a new study, evolutionary mutations in cGAS – an enzyme in the innate immune system that senses DNA to trigger immune responses – may enhance the animal's ability to repair aging-related genetic damage, whereas in other species, such as mice and humans, cGAS can suppress DNA repair.

10 Oct 2025

Scalable synthetic biology revolutionizes targeted therapy with logic-gate proteins

Targeted drug delivery is a powerful and promising area of medicine. Therapies that pinpoint the exact areas of the body where they're needed - and nowhere they're not - can reduce the medicine dosage and avoid potentially harmful "off target" effects elsewhere in the body.

10 Oct 2025

Breakthrough in cancer therapy targets key protein interaction to suppress tumors

Researchers at the Francis Crick Institute and Vividion Therapeutics have identified chemical compounds that can precisely block the interaction between the major cancer-driving gene RAS, and a key pathway for tumor growth.

9 Oct 2025

Researchers discover how plants produce cancer-fighting mitraphylline

Researchers at UBC Okanagan have uncovered how plants produce mitraphylline, a rare natural compound that may help fight cancer.

8 Oct 2025

Common painkiller and antidepressant combo may increase seizure risk in older adults

When older adults living in nursing homes are prescribed the pain medicine tramadol alongside certain antidepressants, their risk of seizures may go up, according to a study published October 8, 2025, in Neurology, the medical journal of the American Academy of Neurology.

8 Oct 2025

Newly identified protein acts as a traffic controller for DNA replication

Mayo Clinic researchers have identified a protein that acts like a traffic controller for DNA, preventing damage during cell division - a discovery that could lead to new cancer therapies, according to a study published in Nature.

8 Oct 2025

Enzyme News and Research

Experimental gene therapy restores immune system function in children with genetic immune disorder

Gene therapy shows long-term success in children with rare immune disorder

What happens when microplastics reach the testes? Study shows autophagy and cell loss

New research aims to develop targeted therapy for hard-to-treat osteosarcoma

Combination therapy shows promising results in patients with rare subtype of non-Hodgkin lymphoma

New wearable sensor tracks vitamin B6 levels in sweat

Estradiol and estriol may protect nerve function in multiple sclerosis

Discovery of CPD gene mutations sheds light on rare congenital hearing loss

Targeting the glycocalyx may offer a new approach to reduce frailty in older adults

Study uncovers key protein complex controlling sperm motility and male fertility

Engineered antibody triggers powerful anti-tumor response in advanced cancers

Targeting aggressive childhood leukemia with nanobody PROTACs

New insights into sperm metabolism could transform infertility treatments

Advances in nanomaterials revolutionize therapy for myocardial ischemia-reperfusion injury

Evolutionary mutation in cGAS enhances naked mole-rat DNA repair

Scalable synthetic biology revolutionizes targeted therapy with logic-gate proteins

Breakthrough in cancer therapy targets key protein interaction to suppress tumors

Researchers discover how plants produce cancer-fighting mitraphylline

Common painkiller and antidepressant combo may increase seizure risk in older adults

Newly identified protein acts as a traffic controller for DNA replication

Biochemical Assays for Efficient Hit Prioritization After Screening eBook

Latest eBooks

Industry Focus eBook - Analytical Chemistry (3rd edition)

Industry Focus eBook - Microbiome (1st edition)

Industry Focus eBook - Cell biology (5th edition)

Advancing degrader and proximity-based drug development

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo