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Antibiotic use makes immune cells less effective in fighting infections

Adding another reason for doctors to avoid the overuse of antibiotics, new research shows that a reduction in the variety of microbes in the gut interferes with the immune system's ability to fight off disease.

17 Aug 2017

Impaired DNA replication may lead to trans-generational inheritance of epigenetic changes

Scientists reveal that a fault in the process that copies DNA during cell division can cause epigenetic changes that may be inherited for up-to five generations.

17 Aug 2017

Sanford Health launches solid tumor oncolytic virus clinical trial

Sanford Health is the first site in the United States to launch a clinical trial using a genetically-engineered virus that aims to destroy therapy-resistant tumors.

17 Aug 2017

Research shows how glutamine plays role in regulating cellular differentiation programs

The 200 different types of cells in the body all start with the same DNA genome. To differentiate into families of bone cells, muscle cells, blood cells, neurons and the rest, differing gene programs have to be turned on or off.

17 Aug 2017

Immunotherapy drug shows favorable safety profile in patients with advanced small cell lung cancer

The immunotherapy drug pembrolizumab has demonstrated a favorable safety profile and "promising durable clinical activity" in pretreated patients who exhibit high levels of the PD-L1 protein in advanced stages of small cell lung cancer (SCLC) – an aggressive form of the disease

16 Aug 2017

Nanobioelectronics to treat bacterial infection in the stomach

Nanotechnology has made another breakthrough at the University of California San Diego. For the first time the researchers have shown that micromotors or microscopic robots could be used to treat a bacterial infection in the stomach in mice models win the laboratory.

16 Aug 2017

Scientists identify basic biological mechanism that kills neurons in ALS

A team led by scientists at St. Jude Children's Research Hospital and Mayo Clinic has identified a basic biological mechanism that kills neurons in amyotrophic lateral sclerosis (ALS) and in a related genetic disorder, frontotemporal dementia (FTD), found in some ALS patients.

16 Aug 2017

Polio vaccine developed using tobacco plants could transform how vaccines are made

Scientists have used plants to create a new polio vaccine in what is hoped to be a breakthrough in the way vaccines are made.

16 Aug 2017

Researchers identify new factors that may affect brain tumor cells' ability to resist treatment

The most aggressive variant of brain tumor - glioblastoma - has an average survival rate of 15 months. There is therefore an urgent need for new treatment strategies for this group of patients.

16 Aug 2017

$Blood tests help predict fracture risk in postmenopausal women$

Blood tests help predict fracture risk in postmenopausal women

In a study published in the Journal of Bone and Mineral Research, blood tests that detect fragments of a protein secreted by bone cells helped to predict fracture risk in postmenopausal women, independently of bone mineral density, bone turnover markers, and other measures of bone health.

16 Aug 2017

Scientists reveal engineered fusion protein that could recover blood vessel health

Scientists from Boston Children's Hospital Vascular Biology Program have revealed an engineered fusion protein that could recover blood vessel health following the onset of hypertension, atherosclerosis, stroke, heart attack, and other cardiovascular diseases.

16 Aug 2017

Research suggests novel approach to treating deadly pancreatic cancer

Pancreatic cancer is now the third leading cause of cancer mortality. Its incidence is increasing in parallel with the population increase in obesity, and its five-year survival rate still hovers at just 8 to 9 percent.

16 Aug 2017

Biochemist explores complex interaction of activation and regulation in fat breakdown

What happens and where, when the body’s fat stores are activated? With the support of the Austrian Science Fund FWF, the biochemist Ruth Birner-Grünberger investigates the complex interaction of activation and regulation in fat breakdown, thus providing a basis for new therapeutic approaches for illnesses such as diabetes or arteriosclerosis.

16 Aug 2017

Lab-grown miniature blood vessels mimic rare Hutchinson-Gilford Progeria Syndrome

Biomedical engineers have grown miniature human blood vessels that exhibit many of the symptoms and drug reactions associated with Hutchinson-Gilford Progeria Syndrome -- an extremely rare genetic disease that causes symptoms resembling accelerated aging in children.

16 Aug 2017

Emory scientists use new tools to detect granulins for the first time inside cells

Emory University School of Medicine researchers have developed tools that enable them to detect small proteins called granulins for the first time inside cells.

14 Aug 2017

Researchers hint at experimental molecular treatment for heart failure

Researchers report encouraging preclinical results as they pursue elusive therapeutic strategies to repair scarred and poorly functioning heart tissues after cardiac injury – describing an experimental molecular treatment for heart failure.

14 Aug 2017

Mayo Clinic researchers discover new cause of treatment resistance in prostate cancer

Mayo Clinic researchers have identified a new cause of treatment resistance in prostate cancer. Their discovery also suggests ways to improve prostate cancer therapy. The findings appear in Nature Medicine.

14 Aug 2017

Dementia and low brain serotonin may be linked: Study finds

Johns Hopkins researchers looked into the brain scans of persons with mild loss of thought and memory and have found that they have significantly low levels of serotonin in their brains. Serotonin is a natural brain chemical that is responsible for several functions including mood, sleep and appetite and also is important for several mental health conditions.

14 Aug 2017

Protein changes essential for normal adult muscle function

Researchers at Baylor College of Medicine have shed light on the process that guides the maturation of newborn muscles into adult, fully functional organs.

14 Aug 2017

SBIR Fast-Track grant to fund study on new drug that targets cardiovascular diseases

The Exscien Corporation of Louisville, KY, in conjunction with LSU Health New Orleans Cardiovascular Center of Excellence, has been awarded an SBIR Fast-Track grant in the amount of $3.7 million over three years by the National Heart, Lung and Blood Institute.

14 Aug 2017

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G Protein News and Research

Antibiotic use makes immune cells less effective in fighting infections

Impaired DNA replication may lead to trans-generational inheritance of epigenetic changes

Sanford Health launches solid tumor oncolytic virus clinical trial

Research shows how glutamine plays role in regulating cellular differentiation programs

Immunotherapy drug shows favorable safety profile in patients with advanced small cell lung cancer

Nanobioelectronics to treat bacterial infection in the stomach

Scientists identify basic biological mechanism that kills neurons in ALS

Polio vaccine developed using tobacco plants could transform how vaccines are made

Researchers identify new factors that may affect brain tumor cells' ability to resist treatment

Blood tests help predict fracture risk in postmenopausal women

Scientists reveal engineered fusion protein that could recover blood vessel health

Research suggests novel approach to treating deadly pancreatic cancer

Biochemist explores complex interaction of activation and regulation in fat breakdown

Lab-grown miniature blood vessels mimic rare Hutchinson-Gilford Progeria Syndrome

Emory scientists use new tools to detect granulins for the first time inside cells

Researchers hint at experimental molecular treatment for heart failure

Mayo Clinic researchers discover new cause of treatment resistance in prostate cancer

Dementia and low brain serotonin may be linked: Study finds

Protein changes essential for normal adult muscle function

SBIR Fast-Track grant to fund study on new drug that targets cardiovascular diseases

How ELRIG Is Helping Mid-Career Scientists Navigate Leadership, Career Change and Redundancy

The role of UV-Vis in biopharma QC

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