Hippocampus News and Research

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The hippocampus is a part of the forebrain, located in the medial temporal lobe. It belongs to the limbic system and plays major roles in short term memory and spatial navigation. Humans and other mammals have two hippocampi, one in each side of the brain.

Novel deep learning model to assess Alzheimer's disease progression risk

Patterns in the Alzheimer's disease (AD) trajectory using Mendelian randomization (MR) and deep learning (DL).

3 Oct 2023

New tau PET radiotracer shows promise for early detection of Alzheimer's disease

A new tau PET radiotracer, 18F-SNFT-1, has been found to be more effective than existing tau PET radiotracers in identifying Alzheimer's disease in its earliest stages, according to research published in the September issue of The Journal of Nuclear Medicine.

29 Sep 2023

Artificial intelligence models for diagnosing post-traumatic stress disorder

Whether AI may be a promising strategy for post-traumatic stress disorder (PTSD) diagnosis.

29 Sep 2023

Loss of brain interneurons linked to cognitive deficits in aging

Normal aging is usually associated with a decline in memory, although it is unclear what factors play a role.

28 Sep 2023

Protein p53 is linked directly to autism-like behavior, study shows

Researchers have established the protein p53 as critical for regulating sociability, repetitive behavior, and hippocampus-related learning and memory in mice, illuminating the relationship between the protein-coding gene TP53 and neurodevelopmental and psychiatric disorders like autism spectrum disorder.

27 Sep 2023

Could CaMKK2 enzyme be the key to treating bipolar disorder?

Researchers explore the role of the CaMKK2 signaling pathway in bipolar disorder, suggesting it as a new treatment target. By targeting this enzyme, scientists aim to develop more effective therapies for bipolar symptoms and metabolic dysfunction.

24 Sep 2023

New study maps the spread of brain changes in psychosis

Psychoses like schizophrenia cost billions of dollars annually and derail the lives of people struggling with the disease.

20 Sep 2023

New brain regions crucial to the formation of long-term memory identified

Researchers at The University of Queensland have identified new regions of the brain crucial to the formation of long-term memory.

20 Sep 2023

The science behind lifestyle's role in preventing depression

A recent paper looks at the effect of a range of lifestyle factors in relation to brain structure, immune function, metabolic pathways, and genetic mechanisms that are responsible for depression.

13 Sep 2023

Shorter telomere length of leucocytes may signal heightened dementia risk

Shorter telomeres on the ends of white blood cell chromosomes may signal a heightened dementia risk, suggest the results of a large long term study, published online in the journal General Psychiatry.

12 Sep 2023

Unlocking the future of dementia: Your telomere length could predict your risk

The recent study in General Psychiatry found that leukocyte telomere length (LTL) is significantly associated with the risk of developing dementia, especially Alzheimer's disease. Using data from over 430,000 individuals, the study suggests that telomere length could serve as a predictive biomarker for brain health and dementia risk.

12 Sep 2023

Can a healthy lifestyle keep depression at bay?

A groundbreaking study reveals that maintaining a healthy lifestyle—including good sleep, social connection, and regular exercise—can significantly reduce the risk of depression, regardless of genetic predisposition. The research emphasizes that lifestyle choices may have a greater impact on depression risk than genetics, offering actionable avenues for prevention.

11 Sep 2023

Study evaluating intranasal anti-CD3 for treatment of Alzheimer’s disease published in the PNAS journal

Tiziana Life Sciences Ltd. (“Tiziana” or the “Company”), a biotechnology company developing breakthrough immunomodulation therapies via novel routes of drug delivery, today announced acceptance of a publication, “Nasal Administration of anti-CD3 monoclonal antibody (mAb) ameliorates disease in a mouse model of Alzheimer’s disease”, in the preeminent journal, Proceedings of the National Academy of Sciences (PNAS), that supports foralumab’s mechanism as a potential treatment for Alzheimer’s disease (AD), a difficult-to-treat neuroinflammatory disease.

9 Sep 2023

Specialized astrocyte subpopulation discovery sheds light on brain health and treatment avenues

In a recent study published in Nature, researchers investigated whether glutamatergic gliotransmission was mediated by specialized astrocytes in the central nervous system.

7 Sep 2023

Teen brains with depression show heightened sensitivity to parental criticism

Adolescents with depression show heightened neural activity in response to parental criticism and are less positively impacted by parental praise, according to a study in Psychological Medicine. The research underscores the importance of psycho-education for parents and clinicians to better understand the unique emotional sensitivities of adolescents with depressive disorders.

6 Sep 2023