Nephrology News and Research

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Nephrology is a branch of internal medicine and pediatrics dealing with the study of the function and diseases of the kidney.

Co-culture with mesenchymal stem cells results in improved viability, function of human hepatocytes

Hepatocyte transplantation is becoming an accepted therapy for acute liver failure, either for liver regeneration or as a bridge to liver transplantation. However, maintaining the viability and functional aspects of hepatocytes has been a concern even with successful freezing.

19 Dec 2013

New guideline to help doctors treat patients with hypertension

A new guideline developed by evidence gathered from randomized clinical trials for the management of high blood pressure contains nine recommendations and a treatment algorithm to help doctors treat patients with hypertension.

19 Dec 2013

Researchers receive Special Challenge Award to investigate role of high protein levels in prostate tumors

Cleveland Clinic, along with the National Cancer Institute, the University of Chicago and Thomas Jefferson University, are the recipients of a $600,000 Special Challenge Award from the Prostate Cancer Foundation (PCF) to investigate the role of abnormally high protein levels in prostate tumors.

18 Dec 2013

Omeros' OMS721 receives FDA orphan drug designation for prevention of TMAs

Omeros Corporation today announced that OMS721, the company's lead human monoclonal antibody targeting mannan-binding lectin-associated serine protease-2 (MASP-2), the key regulator of the lectin pathway of the immune system, has received orphan drug designation from the U.S. Food and Drug Administration for prevention of complement-mediated thrombotic microangiopathies.

18 Dec 2013

ASH and ISH release guidelines for diagnosis and treatment of hypertension

High blood pressure affects approximately one in three adults in the Americas, Europe, some Asian countries and Australia, and one billion people worldwide.

18 Dec 2013

UCLA researchers find no evidence of association between iron levels and atherosclerosis risk

A UCLA research team has found no evidence of an association between iron levels in the body and the risk of atherosclerosis, the hardening and narrowing of the arteries that leads to cardiovascular disease, the No. 1 killer in the U.S.

18 Dec 2013

New projects advance treatments for radiation syndrome, cardiac arrest-induced brain injury and rare blood disorder

The National Institutes of Health today has launched three pre-clinical projects to advance potential new treatments for acute radiation syndrome, brain injury following cardiac arrest and a rare blood disorder called beta thalassemia.

17 Dec 2013

ASH, ISH create new guidelines for diagnosis and treatment of hypertension

High blood pressure affects approximately one in three adults in the Americas, Europe, some Asian countries and Australia, and one billion people worldwide. Because of this epidemic, The American Society of Hypertension, Inc. and the International Society of Hypertension are pleased to announce the creation of first-of-their-kind guidelines for the diagnosis and treatment of Hypertension: "Clinical Practice Guidelines for the Management of Hypertension in the Community."

17 Dec 2013

Researchers use ATX-Red AR-2 as new imaging agent to illuminate tumors

Researchers from Echelon Biosciences, Inc. and collaborators from the University of Utah report the use of ATX-Red AR-2 as a new imaging agent that effectively illuminates tumors.

17 Dec 2013

Paragonix Technologies files FDA Pre-Marketing Notification Application for Sherpa Pak Transporter

Paragonix Technologies, Inc. today announced that it has successfully completed filing of a Pre-Marketing Notification Application (510(k)) with the US Food and Drug Administration for its Sherpa Pak Transporter. The Sherpa Pak Transporter is indicated for the static hypothermic preservation of kidneys during transportation and eventual transplantation into a recipient, using cold storage solutions indicated for use with the kidney.

17 Dec 2013

New report shows death rates for lung cancer dropping at a faster pace

The Annual Report to the Nation on the Status of Cancer, covering the period 1975, showed death rates for lung cancer, which accounts for more than one in four cancer deaths, dropping at a faster pace than in previous years. The recent larger drop in lung cancer deaths is likely the result of decreased cigarette smoking prevalence over many years, and is now being reflected in mortality trends. The lung cancer death rate decline, as well as declines in colorectal, breast, and prostate cancer death rates, has also helped drive decreases in death rates for all cancers types combined, a trend that began about 20 years ago.

17 Dec 2013

Researchers confirm link between contrast agent and abnormalities on brain MRI

For the first time, researchers have confirmed an association between a common magnetic resonance imaging (MRI) contrast agent and abnormalities on brain MRI, according to a new study published online in the journal Radiology. The new study raises the possibility that a toxic component of the contrast agent may remain in the body long after administration.

17 Dec 2013

Janssen receives complete response letter for canagliflozin/metformin FDC therapy for type 2 diabetes

Janssen Research & Development, LLC (Janssen) today announced it has received from the U.S. Food and Drug Administration (FDA) a complete response letter regarding its New Drug Application (NDA) for a fixed-dose combination (FDC) of canagliflozin and immediate-release metformin to treat adults with type 2 diabetes.

16 Dec 2013

FDA accepts Shield Therapeutics' IND application to begin ST10 Phase 3 pivotal study for IDA treatment

Shield Therapeutics, an independent specialty pharmaceutical company focused on the development of mineral-derived hospital pharmaceuticals, today announces that the US Food and Drug Administration has accepted its Investigational New Drug application to initiate a Phase 3 pivotal study of ST10, its novel oral iron-replacement therapy, for the treatment of iron deficiency anaemia in pre-dialysis patients with chronic kidney disease. The Company plans to initiate the Phase 3 study in the US in H1 2014 and positive data would be the cornerstone of a subsequent NDA submission.

16 Dec 2013

IOF Young Investigator Awards presented to five researchers at 4th Asia-Pacific Osteoporosis Meeting

Today, the International Osteoporosis Foundation recognized the outstanding work of five young researchers from China, Chinese Taipei, Hong Kong, Malaysia and Pakistan.

16 Dec 2013

New UCSF-led study links obesity to development of chronic kidney disease

A new UCSF-led study of nearly 3,000 individuals links obesity to the development of kidney disease. The work also shows that, when properly measured, declines in kidney function are detectable long before the emergence of other obesity-related diseases such as diabetes and high blood pressure.

14 Dec 2013

Specialists use pioneering treatment to reduce high blood pressure in kidney patient

SPECIALISTS at Sheffield Teaching Hospitals NHS Foundation Trust have used a pioneering treatment to reduce high blood pressure in a kidney patient whose blood pressure could not be controlled with conventional medication.

13 Dec 2013

Nature Medicine selects CNIO study as most important discovery in regenerative medicine

The prestigious journal Nature Medicine has taken a look at the year and chosen one of the Spanish National Cancer Research Centre's (CNIO) studies as the most important in the stem cell category for its special December edition.

13 Dec 2013

Texas Children's Heart Center opens Center for Preventive Cardiology

Texas Children's Heart Center is proud to announce the opening of the Center for Preventive Cardiology, which is designed to medically manage the risk factors of acquired heart disease in children. The center is the only one of its kind in Texas that offers multidisciplinary, specialized care for children with these risk factors or who have a strong family history of cardiac disease, elevated cholesterol, high blood pressure or the diagnosis of Kawasaki disease.

13 Dec 2013

Study: Antisense drugs show activity in wide range of tissues and organs

Antisense therapeutics, a class of drugs comprised of short nucleic acid sequences, can target a dysfunctional gene and silence its activity. A new study has shown that antisense drugs delivered systemically show activity in a wide range of tissues and organs, supporting their broad therapeutic potential in many disease indications, as described in an article in Nucleic Acid Therapeutics, a peer-reviewed journal from Mary Ann Liebert, Inc., publishers.

13 Dec 2013

Nephrology News and Research

Further Reading

Co-culture with mesenchymal stem cells results in improved viability, function of human hepatocytes

New guideline to help doctors treat patients with hypertension

Researchers receive Special Challenge Award to investigate role of high protein levels in prostate tumors

Omeros' OMS721 receives FDA orphan drug designation for prevention of TMAs

ASH and ISH release guidelines for diagnosis and treatment of hypertension

UCLA researchers find no evidence of association between iron levels and atherosclerosis risk

New projects advance treatments for radiation syndrome, cardiac arrest-induced brain injury and rare blood disorder

ASH, ISH create new guidelines for diagnosis and treatment of hypertension

Researchers use ATX-Red AR-2 as new imaging agent to illuminate tumors

Paragonix Technologies files FDA Pre-Marketing Notification Application for Sherpa Pak Transporter

New report shows death rates for lung cancer dropping at a faster pace

Researchers confirm link between contrast agent and abnormalities on brain MRI

Janssen receives complete response letter for canagliflozin/metformin FDC therapy for type 2 diabetes

FDA accepts Shield Therapeutics' IND application to begin ST10 Phase 3 pivotal study for IDA treatment

IOF Young Investigator Awards presented to five researchers at 4th Asia-Pacific Osteoporosis Meeting

New UCSF-led study links obesity to development of chronic kidney disease

Specialists use pioneering treatment to reduce high blood pressure in kidney patient

Nature Medicine selects CNIO study as most important discovery in regenerative medicine

Texas Children's Heart Center opens Center for Preventive Cardiology

Study: Antisense drugs show activity in wide range of tissues and organs

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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