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New study uncovers multiple effects of little-known DNA repair protein

Injury and repair are part of the normal life cycle of any tissue or organ in the human body. However, if macroscopic tears or breaks occur in the bones or joints, for instance, the effects are immediately perceptible. Not so with chromosomes, which contain the DNA of life. Both extremely valuable and extremely fragile, DNA is the focus of highly efficient repair proteins.

2 Dec 2019

Over €12 million funding to advance autophagy research

Four years ago, Collaborative Research Centre (CRC) 1177 on selective autophagy was established under the leadership of Goethe University - now the German Research Foundation has given the green light for its further funding.

27 Nov 2019

Splicing factor enhances ability of triple negative breast cancers to grow and metastasize

If your DNA is a cookbook, a single gene is a recipe. But it's a flexible recipe that if edited one way can make a pie; edited another way can make a cake. And that difference can mean cancer, as a team of researchers who looked at those gene editors writes in the 26 November issue of Cell Reports.

26 Nov 2019

Key mechanism identified for how antiviral immune responses reprogram liver metabolism

Researchers at the CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences identified a key mechanism for how antiviral immune responses reprogram liver metabolism. Their recent study, which was published in the renowned scientific journal Immunity, investigated the communication between inflammation and liver metabolism during chronic viral infection.

26 Nov 2019

Studying the genomes of hibernating mammals could improve understanding and treatment of obesity

A discovery about mammalian genomes and hibernation could aid understanding and treatment of obesity and metabolic disorders.

26 Nov 2019

Discovery in C. difficile biology opens new window to developing treatments for dangerous infections

A process called sporulation that helps the dangerous bacterium Clostridium difficile (C. difficile) to survive inhospitable conditions and spread is regulated by epigenetics, factors that affect gene expression beyond the DNA genetic code, researchers at the Icahn School of Medicine at Mount Sinai report.

25 Nov 2019

Researchers assess safety of conditionally immortalized cells for bioartificial kidney application

Here, the research team assessed the safety of conditionally immortalized proximal tubule epithelial cells for bioartificial kidney application, by using in vitro assays and athymic nude rats.

25 Nov 2019

Genes that help intestinal stem cells burn dietary fat may play a role in colon cancer

Two genes that appear to help stem cells in the intestine burn dietary fat may play a role in colon cancer, according to a Rutgers study.

25 Nov 2019

Scientists investigate the dynamics of molecular changes in gliomas

Until relatively recently, cancer was viewed as a single disease with sub-types based on where in the body it arose.

22 Nov 2019

Researchers investigate a hospital outbreak in real time using high-resolution technique

On the European Antibiotic Awareness Day, researchers announce the results of a pilot study completed in record time. The initiative opens new perspectives for the control of bacterial infections in Portuguese hospitals.

21 Nov 2019

Coriell Institute for Medical Research wins $7.7 million NINDS contract

Coriell Institute for Medical Research has been awarded a $7.7 million contract by the National Institute of Neurological Disorders and Stroke, part of the National Institutes of Health focused on the study of nervous system disorders.

21 Nov 2019

Doughnut-shaped circles of ecDNA provide tumor cells with a malignant twist

Deoxyribonucleic acid or DNA encodes information, not only in its sequence but also in its shape.

21 Nov 2019

Study uncovers new Alzheimer's risk gene

A new paper in the Journal of Neuropathology & Experimental Neurology finds a gene that may help explain a large part of the genetic risk for developing Alzheimer's disease.

21 Nov 2019

Scientists discover new molecular drivers of Parkinson's disease

Scientists at the Icahn School of Medicine at Mount Sinai have uncovered new molecular drivers of Parkinson's disease using a sophisticated statistical technique called multiscale gene network analysis.

20 Nov 2019

Subpopulations of tumor cells may exhibit diverging behaviors from bulk tumor

Subpopulations of tumor cells may exhibit diverging behaviors from the bulk tumor due to an alternate stress response that diverts tumor cells from apoptotic death.

20 Nov 2019

New database helps identify therapeutic targets to fight infectious diseases

Infectious diseases are caused by pathogenic microorganisms capable of entering, colonizing and growing within a host organism, thus producing an infection. Bacterial infections have been on the rise worldwide in recent years, but many mechanisms underlying bacterial pathogenesis are still poorly understood.

19 Nov 2019

Rutgers Cancer Institute researchers awarded $2.3 million in American Cancer Society grants

More than $2.3 million in Research Scholar Grants from the American Cancer Society have been awarded to three Rutgers Cancer Institute of New Jersey researchers to examine cell metabolism and tumor formation in forms of breast cancer, lung cancer and leukemia.

19 Nov 2019

Tailored T-cells safe, may be effective in preventing and treating multiple viral infections

Tailored T-cells specially designed to combat a half dozen viruses are safe and may be effective in preventing and treating multiple viral infections, according to research led by Children's National Hospital faculty.

18 Nov 2019

Rare DNA variants linked to sudden cardiac death

Sudden cardiac death affects 220,000 U.S. adults annually, most of whom have no prior symptoms of a heart issue.

17 Nov 2019

Non-coding enhancer DNA may be key for identifying genetic risk in neurological conditions

One might think that the primary cause of most genetically linked diseases comes from mutations in coding DNA -- alterations in coding regions of the genome that can lead directly to changes in the expression of particular proteins important for a healthy body.

14 Nov 2019

Genomic News and Research

New study uncovers multiple effects of little-known DNA repair protein

Over €12 million funding to advance autophagy research

Splicing factor enhances ability of triple negative breast cancers to grow and metastasize

Key mechanism identified for how antiviral immune responses reprogram liver metabolism

Studying the genomes of hibernating mammals could improve understanding and treatment of obesity

Discovery in C. difficile biology opens new window to developing treatments for dangerous infections

Researchers assess safety of conditionally immortalized cells for bioartificial kidney application

Genes that help intestinal stem cells burn dietary fat may play a role in colon cancer

Scientists investigate the dynamics of molecular changes in gliomas

Researchers investigate a hospital outbreak in real time using high-resolution technique

Coriell Institute for Medical Research wins $7.7 million NINDS contract

Doughnut-shaped circles of ecDNA provide tumor cells with a malignant twist

Study uncovers new Alzheimer's risk gene

Scientists discover new molecular drivers of Parkinson's disease

Subpopulations of tumor cells may exhibit diverging behaviors from bulk tumor

New database helps identify therapeutic targets to fight infectious diseases

Rutgers Cancer Institute researchers awarded $2.3 million in American Cancer Society grants

Tailored T-cells safe, may be effective in preventing and treating multiple viral infections

Rare DNA variants linked to sudden cardiac death

Non-coding enhancer DNA may be key for identifying genetic risk in neurological conditions

Industry focus eBook: Genomics (4th edition) eBook

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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