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Trial establishes the clinical utility of circulating tumor cell count as biomarker in breast cancer care

The use of circulating tumor cell (CTC) count to guide the choice between chemotherapy and endocrine therapy as first-line therapy for patients with metastatic, estrogen receptor (ER)-positive/HER2-negative breast cancer provided overall survival benefit, compared with physician's choice of treatment, according to data from the STIC CTC trial presented at the San Antonio Breast Cancer Symposium, held December 6-10, 2022.

8 Dec 2022

Therapeutic activation of p53 could offer new treatment option for salivary gland cancer

Researchers at the University of Michigan Rogel Cancer Center and School of Dentistry found that certain drugs can change the fundamental makeup of cancer stem cells in mouse models of mucoepidermoid carcinoma – a lethal form of salivary gland cancer that currently has no treatment options.

8 Dec 2022

What are the associations of metabolome, microbiome, and immune perturbations with severe COVID-19?

In a new study, researchers observed that coronavirus disease 2019 (COVID-19) progression and inflammatory responses are associated with changes in the metabolome and microbiome.

8 Dec 2022

Booster COVID-19 mRNA vaccinations marginally increase the durability of neutralizing antibody responses

Researchers investigated the immunological mechanisms behind the decreasing efficacy of COVID-19 vaccines by evaluating the durability and magnitude of neutralizing antibodies and memory B and T cell responses to booster doses of mRNA COVID-19 vaccine.

8 Dec 2022

Study shows how dietary saturated/trans fats promote liver tumorigenesis

Fatty foods harm our health. Prior research has established a link between the consumption of dietary fats and non-alcoholic fatty liver disease, which subsequently leads to inflammation and tumor formation in the liver.

7 Dec 2022

Liver cancer study could help improve the safety of certain gene therapies for hemophilia

Research led by Randal J. Kaufman, Ph.D., has found that misfolded proteins in liver cells contribute to the development of liver cancer, shedding new light on the mysterious origins of one of the world's deadliest diseases.

7 Dec 2022

Cancer immunotherapies can become more potent depending on the time of day

Scientists from the UNIGE and LMU show that the anti-tumor activity of the immune system - and the effectiveness of cancer immunotherapies - depends on the time of day.

7 Dec 2022

Study reports overall response of HER2-low breast cancer patients to neoadjuvant T-DXd treatment

Patients with localized, hormone receptor-positive, HER2-low breast cancer treated with trastuzumab deruxtecan (T-DXd, Enhertu) in the neoadjuvant setting had an overall response rate of 75 percent in the absence of anastrozole and 63 percent in combination with anastrozole, according to results from the phase II TRIO-US B-12 TALENT trial presented at the San Antonio Breast Cancer Symposium, held December 6-10, 2022.

7 Dec 2022

New ASTRO guideline provides recommendations on the use of radiation therapy for endometrial cancer

A newly updated clinical guideline from the American Society for Radiation Oncology provides recommendations on the use of radiation therapy and systemic therapy after surgery to treat patients with endometrial cancer.

7 Dec 2022

BGI Genomics and the University of Pécs launch a joint laboratory in Hungary

On November 29, 2022, BGI Genomics and the University of Pécs (UP) agreed to launch a joint laboratory in Hungary.

6 Dec 2022

Discovery of three new brain tumor subtypes could help to identify novel, effective therapies

Research lead by RCSI University of Medicine and Health Sciences has discovered three new subtypes of brain tumor which could help to identify new and effective therapies.

6 Dec 2022

Innovative precision oncology enabled by micro-organospheres derived from patients

The development of an automatic microfluidics droplet platform to rapidly generate patient-derived models of cancer.

6 Dec 2022

Study suggests new anti-KRAS drug as a strong candidate for pancreatic cancer clinical trials

A small molecule inhibitor that attacks the difficult to target, cancer-causing gene mutation KRAS, found in nearly 30 percent of all human tumors, successfully shrunk tumors or stopped cancer growth in preclinical models of pancreatic cancer, researchers from Penn Medicine's Abramson Cancer Center showed, suggesting the drug is a strong candidate for clinical trials.

6 Dec 2022

Research explores how alignment of endothelial cells plays a role in cancer metastasis

Preventing metastasis – the development of cancer cells beyond their original location – remains one of the major goals of current cancer research.

6 Dec 2022

Largest machine learning effort securely aggregates data from brain scans of glioblastoma patients

Researchers at Penn Medicine and Intel Corporation led the largest-to-date global machine learning effort to securely aggregate knowledge from brain scans of 6,314 glioblastoma (GBM) patients at 71 sites around the globe and develop a model that can enhance identification and prediction of boundaries in three tumor sub-compartments, without compromising patient privacy.

6 Dec 2022

The critical role of flow cytometry in CAR+ T-Cell trials

In this interview, Ryan Muise talks to AZoNetwork about the added value of using flow cytometry in CAR T-Cell clinical trials.

From Cerba Research 6 Dec 2022

Researchers discover new mechanism that enables cancer cells to move throughout the body

An international team of researchers has uncovered a new mechanism that enables cancer cells to move throughout the body, providing a potential new target to stop metastasis, which is responsible for 90 per cent of cancer deaths.

5 Dec 2022

Comparison of blood plasma protein expression in mild, moderate, and severe COVID-19 identifies novel disease severity biomarkers

Researchers evaluated blood plasma proteins to identify new targets for COVID-19 treatment approaches and prevent complications associated with severe illness.

5 Dec 2022

AI could make doctors’ work simpler, faster, and more precise

One in nine women in the developed world will be diagnosed with breast cancer at some point in her life. The prevalence of breast cancer is increasing, an effect caused in part by the modern lifestyle and increased lifespans.

2 Dec 2022

Pumpkin byproducts exhibit antioxidant and antimicrobial activity

Researchers characterized the bioactive agents in the food industry byproducts of pumpkins.

2 Dec 2022

Tumor News and Research

Trial establishes the clinical utility of circulating tumor cell count as biomarker in breast cancer care

Therapeutic activation of p53 could offer new treatment option for salivary gland cancer

What are the associations of metabolome, microbiome, and immune perturbations with severe COVID-19?

Booster COVID-19 mRNA vaccinations marginally increase the durability of neutralizing antibody responses

Study shows how dietary saturated/trans fats promote liver tumorigenesis

Liver cancer study could help improve the safety of certain gene therapies for hemophilia

Cancer immunotherapies can become more potent depending on the time of day

Study reports overall response of HER2-low breast cancer patients to neoadjuvant T-DXd treatment

New ASTRO guideline provides recommendations on the use of radiation therapy for endometrial cancer

BGI Genomics and the University of Pécs launch a joint laboratory in Hungary

Discovery of three new brain tumor subtypes could help to identify novel, effective therapies

Innovative precision oncology enabled by micro-organospheres derived from patients

Study suggests new anti-KRAS drug as a strong candidate for pancreatic cancer clinical trials

Research explores how alignment of endothelial cells plays a role in cancer metastasis

Largest machine learning effort securely aggregates data from brain scans of glioblastoma patients

The critical role of flow cytometry in CAR+ T-Cell trials

Researchers discover new mechanism that enables cancer cells to move throughout the body

Comparison of blood plasma protein expression in mild, moderate, and severe COVID-19 identifies novel disease severity biomarkers

AI could make doctors’ work simpler, faster, and more precise

Pumpkin byproducts exhibit antioxidant and antimicrobial activity

Industry Focus eBook - Cell & Gene Therapy (1st Edition) eBook

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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