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OGT launches high-quality NGS panel for research into Chronic Lymphocytic Leukemia

Oxford Gene Technology, A Sysmex Group Company, is excited to announce the launch of its SureSeq CLL + CNV Panel — the company’s latest high-quality, next-generation sequencing offering for research into Chronic Lymphocytic Leukaemia.

From Oxford Gene Technology 16 Jan 2020

Common genetic defect in prostate cancer associated with worse prognosis

Like security screening to make sure nothing harmful makes its way into a crowded area, cells in the human body use checkpoints to control their growth and prevent harmful mutations from making their way into new cell populations and causing trouble.

9 Jan 2020

New insights into the most perplexing medical mysteries associated with schizophrenia

Four unsolved mysteries around schizophrenia have long plagued the medical community, but a new hypothesis identifying a common link between them and an almost forgotten epidemic of a disease called pellagra could have profound implications for our understanding of psychosis in poorer nations.

12 Dec 2019

Rutgers researchers identify small mutations for AML and MDS through deep DNA sequencing

Deep DNA sequencing analysis conducted by Rutgers Cancer Institute of New Jersey investigators examining genomic differences within tumors for prediction of disease relapse in certain hematologic malignancies has identified small mutations.

9 Dec 2019

Dynamics of crucial immune system proteins revealed

Of the many marvels of the human immune system, the processing of antigens by the class I proteins of the major histocompatability complex (MHC-I) is among the most mind-boggling. Exactly how these proteins carry out their crucial functions has not been well understood.

3 Dec 2019

Non-coding enhancer DNA may be key for identifying genetic risk in neurological conditions

One might think that the primary cause of most genetically linked diseases comes from mutations in coding DNA -- alterations in coding regions of the genome that can lead directly to changes in the expression of particular proteins important for a healthy body.

14 Nov 2019

Three-drug combination improves lung function, reduces symptoms in CF patients

A phase three clinical trial that UT Southwestern participated in determined that a three-drug combination improved lung function and reduced symptoms in cystic fibrosis patients who have a single copy of the most common genetic mutation for the disease.

31 Oct 2019

New genomics technique can be used to track down the causes of rare genetic diseases

A team led by a scientist at Scripps Research has invented a new genomics technique for tracking down the causes of rare genetic diseases.

11 Oct 2019

Scientists discover new patterns in the evolution of the influenza virus

Researchers from Skoltech have found that the devious influenza virus is capable of new patterns of evolution and mutation in order to escape treatment with the currently available drugs and prevention with the currently available vaccines. This discovery however could help researchers predict the potential mutations in the genome of the virus and ultimately help them develop and design more effective vaccines against influenza.

9 Oct 2019

Study: Heart disease is associated with allopurinol-related severe skin reactions

Heart disease is an independent risk factor for severe adverse skin reactions in patients taking allopurinol, found a study published in CMAJ (Canadian Medical Association Journal).

30 Sep 2019

Altered microbiome in fruit flies can drive evolutionary change

The expression "you are what you eat" has taken on new meaning. In an experiment in fruit flies, or Drosophila melanogaster, researchers at the University of Pennsylvania have found that adding different species of microbes to the flies' food caused populations to diverge genetically, racking up significant genomic changes in just five generations.

18 Sep 2019

Cancer disease incidence and severity influenced by gene mutation, tissue location

The KRAS gene is one of the commonly mutated genes in cancer. More than 40 percent of colorectal cancers have a mutated KRAS gene, or oncogene, that is at least partially responsible for cancer development.

12 Sep 2019

New discovery may help identify type 1 diabetes earlier than is currently possible

Type 1 diabetes, an autoimmune disease that typically emerges before the age of 20, wipes out the body's ability to produce insulin--a hormone that's essential to life. Diagnosis often comes after symptoms arise, at which point the disease has taken hold.

30 Aug 2019

New study helps explain why lung tumors turn aggressive

Lung cancer is the number 1 killer among cancers, especially when it is of the non-small cell type. Among these, adenocarcinomas are the most common and aggressive type. These tumors also show a strong tendency to show dedifferentiation, or loss of the features that characterize a mature lung cell.

28 Aug 2019

New study reveals exosome-mediated communication between mother and baby

During pregnancy, the mother and the baby communicate in a variety of ways. For instance, signals from the fetus are crucially involved in the initiation of labor and delivery.

22 Aug 2019

Type 1 diabetes linked to gut microbiome and genetic factors

A new study has revealed that the gut microbiome of children with a high genetic risk of developing type 1 diabetes is markedly different from those who have a low risk of the condition.

20 Aug 2019

Genetic risk for autoimmunity may be linked to differences in gut microbiome

Children with increased genetic risk of type 1 diabetes have different gut microbiomes than those with low risk, a new study found.

20 Aug 2019

Genetic variant increases risk of addiction in the presence of childhood stress

What causes some people to become alcoholics or drug abusers when faced with stress, but not others? This question has plagued addiction researchers for decades.

19 Aug 2019

Alzheimer's gene may affect cognitive health before adulthood, study finds

The Apolipoprotein E (APOE) is a major cholesterol carrier that aids in lipid transport and injury repair in the brain. It packages cholesterol and other fats and moves them through the bloodstream. APOE polymorphic alleles are the major genetic factors for the risk of Alzheimer’s disease (AD).

19 Jul 2019

Researchers identify genetic factor linked to development of diabetic peripheral neuropathy

Researchers from Joslin Diabetes Center, using a genome-wide association study, have identified a genetic factor linked to the development of diabetic peripheral neuropathy.

12 Jun 2019