Metformin News and Research

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Metformin is the active ingredient in a drug used to treat diabetes mellitus (a condition in which the body cannot control the level of sugar in the blood). It is also being studied in the treatment of cancer. It decreases the amount of glucose (a type of sugar) released into the bloodstream from the liver and increases the body’s use of the glucose. Metformin is a type of antidiabetic agent.

Research unlocks potential new therapies for inflammatory diseases

Macrophages are frontline cells in our immune system. They detect microbial invaders and also tissue injury and then mount an appropriate response needed to clear the infection and repair the damaged tissue.

5 Dec 2016

Targeting metabolic function of breast cancer may help combat disease

How does a cancer cell burn calories? New research from Thomas Jefferson University shows that breast cancer cells rely on a different process for turning fuel into energy than normal cells.

28 Nov 2016

Early identification may be key to stop type 2 diabetes

What's the best way to stop type 2 diabetes? Find it before it becomes a problem. "The phrase I use is prevention by detection," said Joseph Aloi, M.D., section chief of endocrinology and metabolism at Wake Forest Baptist Medical Center in Winston-Salem, North Carolina.

16 Nov 2016

Certain anti-diabetic drugs can switch off molecule that plays key role in inflammatory diseases

A molecule thought to play a key role in some inflammatory diseases can be switched off by two widely used medicines, new research has shown.

9 Nov 2016

Targeted precision medicine can eliminate cancer risk in patients with Type 2 diabetes

The links between Type 2 diabetes and cancer are complex: people suffering from diabetes mellitus essentially have a higher risk of developing cancer but, on top of that, some diabetes drugs are also suspected of increasing the risk in some cases.

8 Nov 2016

Type 2 diabetes epidemic worse than previously thought, reveals new research

EXASOL, provider of the world’s fastest in-memory analytic database, today releases the most in-depth analysis ever carried out into type 2 diabetes medication prescribing in England.

12 Oct 2016

$New review shows both types of diabetes increase risk of fragility fractures$

New review shows both types of diabetes increase risk of fragility fractures

Recent research has shown that bone health is compromised in people with diabetes, resulting in a significantly higher risk of fragility fracture.

4 Oct 2016

Novel bifunctional dimers show promise in preventing Parkinson's disease

A team of researchers from the University of Saskatchewan has developed two caffeine-based chemical compounds that show promise in preventing the ravages of Parkinson's disease.

30 Sep 2016

NTU scientists develop new test kit for rapid detection of inflammation in diabetic patients

Scientists from Nanyang Technological University, Singapore have developed a new kit that will allow doctors to find out within minutes if diabetic patients are suffering from inflammation.

27 Sep 2016

ATA announces winner of John B. Stanbury Thyroid Pathophysiology Medal

The American Thyroid Association will present the John B. Stanbury Thyroid Pathophysiology Medal to Kenneth D. Burman, M.D. at the ATA's 86th Annual Meeting, September 21-25, 2016, in Denver, Colorado.

21 Sep 2016

Oral antidiabetic drug modulates the body's nitrogen and urea metabolism

The most frequently prescribed oral antidiabetic drug metformin significantly affects metabolic pathways.

14 Sep 2016

Diabetes drug linked to decreased weight gain in children with autism spectrum disorder

The diabetes medication metformin hydrochloride was associated with decreased weight gain in a small clinical trial of children and adolescents with autism spectrum disorder who were taking atypical antipsychotics to treat symptoms of irritability and agitation, according to an article published online by JAMA Psychiatry.

24 Aug 2016

Specific molecular features control uptake of biguanides into mitochondria to inhibit respiration

The biguanides are a family of drugs with diverse clinical applications. Metformin, a widely used anti-hyperglycemic biguanide, suppresses mitochondrial respiration by inhibiting respiratory complex I. Phenformin, a related anti-hyperglycemic biguanide, also inhibits respiration, but proguanil, which is widely used for the prevention of malaria, does not.

12 Aug 2016

Metabolic-checkpoint inhibitor combination approach may improve cancer therapies

Reprogramming of the molecular pathways underlying normal metabolism is essential for T cell infection-fighting function and for the immune system to form a "memory" of the microbes it has already encountered. But exactly how metabolism in exhausted T cells is maintained in chronic infections and cancer is a missing element in this line of research.

3 Aug 2016

FDA approves new injection to improve blood sugar levels in adults with type 2 diabetes

The U.S. Food and Drug Administration approved Adlyxin (lixisenatide), a once-daily injection to improve glycemic control (blood sugar levels), along with diet and exercise, in adults with type 2 diabetes.

28 Jul 2016

Common drug for type 2 diabetes may play surprising role in preventing preterm birth

Metformin, a medication routinely used by millions of people with type 2 diabetes, may also play an unexpected role in blocking a significant cause of preterm birth, according to research findings published July 25.

26 Jul 2016

Risk of hypoglycemia differs between SU agents, study reveals

Adding sulphonylureas (SUs) to metformin remains a commonly used strategy for treating type 2 diabetes, but individual SUs differ and may confer different risks of abnormally low blood sugar, or hypoglycemia. SUs-which include newer generation agents such as gliclazide, glipizide, glimepiride, and glibenclamide-stimulate the production of insulin in the pancreas and increase the effectiveness of insulin in the body.

20 Jul 2016

Diabetes drug metformin could help reduce toxic acid levels linked to MSUD

Maple Syrup Urine Disease (MSUD) is a rare inherited metabolic disorder involving the dysfunction of an enzyme which breaks down three essential amino acids: leucine, isoleucine and valine.

6 Jul 2016

Experimental lipid-lowering drug improves glucose control in diabetic patients

High triglycerides -- a type of fat, or lipid, in the blood -- increase the risk of heart disease and perhaps type 2 diabetes. For the first time, it has been shown that profoundly lowering triglycerides in diabetics improves their insulin sensitivity over time, which helps them maintain healthy glucose - blood sugar -- levels.

28 Jun 2016

Liraglutide drug effectively decreases cardiovascular disease risk in type 2 diabetes patients

Researchers have shown that the glucose-lowering drug liraglutide safely and effectively decreases the overall risk of heart attack, stroke, or cardiovascular death for people with type 2 diabetes.

14 Jun 2016