Type 2 diabetes can be reversed with intensive medical treatment, study shows

Type 2 diabetes can be reversed with intensive medical treatment using oral medications, insulin and lifestyle therapies, according to a study published in the Endocrine Society's Journal of Clinical Endocrinology & Metabolism.

Type 2 diabetes is typically thought of as a chronic condition. As it progresses, individuals with type 2 diabetes often need to use a healthy diet, exercise and an increasingly complex combination of medications to manage the condition.

"By using a combination of oral medications, insulin and lifestyle therapies to treat patients intensively for two to four months, we found that up to 40 percent of participants were able to stay in remission three months after stopping diabetes medications," said the study's first author, Natalia McInnes, MD, MSc, FRCPC, of McMaster University and Hamilton Health Sciences, in Hamilton, Ontario, Canada. "The findings support the notion that type 2 diabetes can be reversed, at least in the short term—not only with bariatric surgery, but with medical approaches."

One in 10 American adults has type 2 diabetes, according to the Society's Endocrine Facts and Figures report. The condition occurs when an individual doesn't produce enough insulin—the hormone that allows cells to absorb glucose in the blood—or the pancreas isn't making insulin as efficiently as it could. As a result, blood sugars build up in the body and the cells do not receive the energy they need.

To study ways to put type 2 diabetes into remission, the researchers randomly divided 83 individuals with the condition into three study groups. Two of the groups received an intensive metabolic intervention where they were provided with a personalized exercise plan and a suggested meal plan that reduced their daily calorie intake by 500 to 750 calories a day. These study participants met regularly with a nurse and dietitian to track their progress and received oral medications and insulin at bedtime to tightly manage their blood glucose levels. One group underwent the intervention for eight weeks, while the other was treated intensively for 16 weeks. After the intervention, individuals in both groups stopped taking diabetes medications and were encouraged to continue with lifestyle changes.

The two intervention groups were compared to a control group of individuals with type 2 diabetes. Participants in this group received standard blood sugar management advice from their usual healthcare provider for the duration of the trial, and they received standard lifestyle advice. Participants in all three groups received usual diabetes care if they experienced a diabetes relapse.

Study participants had their average blood glucose levels from the past two to three months measured using a HbA1C blood test at eight, 20, 28 and 52 weeks to gauge how well their blood sugar was controlled. They also undertook oral glucose tolerance tests.

Three months after the intervention was completed, 11 out of 27 individuals in the 16-week intervention group met HbA1C criteria for complete or partial diabetes remission, compared to four out of 28 individuals in the control group. Three months after finishing the eight-week intervention, six out of 28 individuals in that group met the same criteria for complete or partial diabetes remission.

"The research might shift the paradigm of treating diabetes from simply controlling glucose to an approach where we induce remission and then monitor patients for any signs of relapse," McInnes said. "The idea of reversing the disease is very appealing to individuals with diabetes. It motivates them to make significant lifestyle changes and to achieve normal glucose levels with the help of medications. This likely gives pancreas a rest and decreases fat stores in the body, which in turn improves insulin production and effectiveness."

The senior investigator on the trial, Hertzel C. Gerstein, MD, MSc, FRCPC, of McMaster University and Hamilton Health Sciences added, "We chose to use metformin, acarbose and basal insulin glargine in this trial as these medications have all been shown to slow or prevent the development of type 2 diabetes. However, other drug combinations could lead to higher remission rates and need to be systematically studied with regard to this outcome."


  1. Faruz Ur Tev Faruz Ur Tev United States says:

    Big pharma LIES!  I reversed my Type II diabetes with diet and exercise.  I followed a strict regimen of limited carbs and daily exercise, dropped 40 lbs and beat the disease.  You can, too! Discipline -- not drugs.

    • Randy Dandy Randy Dandy United States says:

      Type II diabetes is not "The condition occurs when an individual doesn't produce enough insulin . .", as stated by the author.  It is a lack of insulin sensitivity in the receptor cells.  Insulin is abundant but not useable.
      Type II diabetes is a lifestyle illness, only requires cutting out carbs, increasing good fat and lots of exercize.  It will resolve on it's own.

  2. Randy Dandy Randy Dandy United States says:

    To begin with the author says:  "The condition occurs when an individual doesn't produce enough insulin . ."
    This is incorrect.  The author is describing Type I diabetes.  Type II diabetes is the loss of insulin sensitivity by receptor cells making it difficult to absorb sugar.  The condition causes an excess of insulin in the system causing a cascade of other maladies.
    Second:  Type II diabetes is a lifestyle illness.  Cut out carbs, increase GOOD fat intake, excersize and 90% of Type II diabetes cases are resolved without medication or surgery.

  3. Sally Sue Sally Sue United States says:

    Type 2 diabetes usually begins with insulin resistance, a condition in which muscle, liver, and fat cells do not use insulin well. As a result, your body needs more insulin to help glucose enter cells. At first, the pancreas makes more insulin to keep up with the added demand. Over time, the pancreas can’t make enough insulin, and blood glucose levels rise.

  4. Colleen Baker Colleen Baker United States says:

    I was told almost 2 years ago that I have type 2 diabetes.  I went on Metformin, lost 25 pounds with changes to my eating.  Worked in my yard  a lot for exercise.  Then I got some kind of arthritis in both feet and have not been able to do as much activity.  Long story short..I started sitting more, eating carbs more and more and now I am flabby have gained back almost 8 lbs over the last year and I have huge bags under my eyes that I swear get bigger daily.  I do I get back to when I was first diagnosed.  I go to my Dr's in April and she will be mighty disappointed when she sees me.

  5. Colleen Baker Colleen Baker United States says:

    I meant to ask HOW do I get back to when I was first diagnosed.  Any way to kick start myself?

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