Pathology News and Research

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Pathology is the study and diagnosis of disease through examination of organs, tissues, bodily fluids, and whole bodies (autopsies). The term also encompasses the related scientific study of disease processes, called General pathology. Medical pathology is divided in two main branches, Anatomical pathology and Clinical pathology. Veterinary pathology is concerned with animal disease whereas Phytopathology is the study of plant diseases.

Jumping genes reshape cancer genomes through 3D chromatin interactions

Scientists at St. Jude Children's Research Hospital have revealed previously unappreciated roles for the retrotransposon LINE-1 in shaping the cancer genome structure and regulation.

5 Jan 2026

Finger-prick blood tests enable remote detection of Alzheimer’s biomarkers

A groundbreaking international study has demonstrated that Alzheimer's disease biomarkers can be accurately detected using simple finger-prick blood samples that can be collected at home and mailed to laboratories without refrigeration or prior processing.

5 Jan 2026

Study uncovers a possible biomarker linked to MS disease progression

A new University of Toronto-led study has discovered a possible biomarker linked to multiple sclerosis (MS) disease progression that could help identify patients most likely to benefit from new drugs.

2 Jan 2026

Researchers explore why Alzheimer's affects men and women differently

More than seven million Americans have Alzheimer's disease, and two-thirds of them are women, according to the Alzheimer's Association. The O'Banion Lab at the Del Monte Institute for Neuroscience at the University of Rochester has long been studying this disease and is looking more closely at the differences between male and female brains.

30 Dec 2025

Restoring brain energy balance reverses Alzheimer’s disease in mouse models

For over a century, Alzheimer's disease (AD) has been considered irreversible. Consequently, research has focused on disease prevention or slowing, rather than recovery.

23 Dec 2025

Engineered extracellular vesicles enable antigen-specific regulatory T cell induction

A research team at the Nano Life Science Institute (WPI-NanoLSI) and the Faculty of Medicine at Kanazawa University has developed a new class of engineered extracellular vesicles (EVs) capable of inducing antigen-specific regulatory T cells (Tregs), the immune cells that play a central role in suppressing excessive immune responses.

22 Dec 2025

Simple blood test maps hidden Alzheimer’s disease changes

This population-based study used plasma pTau217 to estimate how common Alzheimer’s disease neuropathological changes are across age and cognitive status in a Norwegian community cohort. Prevalence rose steeply with age and was strongly associated with APOE ε4 genotype, education level, and kidney function, with implications for future use of blood biomarkers in clinical practice.

21 Dec 2025

Hidden kinase state enables rapid and repeated protein phosphorylation

Scientists at St. Jude Children's Research Hospital have characterized a hidden intermediate state at the center of Src kinase function. This hidden state allows the kinase to repeatedly modify its target, without needing to release and reattach to the target each time.

19 Dec 2025

Long-approved drug shows promise in slowing neuron loss in Alzheimer’s disease

Scientists at the University of Colorado Anschutz have discovered that while brain neuron changes, including cell loss, may begin in early life, a drug long-approved for other conditions might be repurposed to slow this damage, offering new hope for those with Alzheimer's disease (AD) and other cognition issues.

19 Dec 2025

Ants show new promise as a source of powerful antibiotics

Has a crucial component to the development of human medicine been hiding under our feet?

18 Dec 2025

Compact Raman imaging system detects tumors with high sensitivity

Researchers have developed a new compact Raman imaging system that is sensitive enough to differentiate between tumor and normal tissue.

18 Dec 2025

Everyday light exposure shapes how alert and mentally sharp we feel outside the lab

This real-world study shows that recent and habitual light exposure are linked to lower subjective sleepiness and faster reaction times in daily life. Brighter and more stable daytime light patterns were associated with better performance on specific cognitive tasks, independent of sleep and time of day.

18 Dec 2025

Experimental drug targets early toxic amyloid to slow Alzheimer’s disease

An experimental drug developed at Northwestern University has demonstrated further promise as an early intervention for Alzheimer's disease.

18 Dec 2025

Lysophosphatidylcholines show gene-dependent effects in early Alzheimer’s disease

A new study presents robust evidence on the role of lysophosphatidylcholines (LPCs) in the onset of Alzheimer's disease. Researchers discovered that LPCs-compounds that transport a variety of healthy fatty acids to the brain-either promote Alzheimer's or protect against it, depending on a person's genetics.

17 Dec 2025

Hyperphosphorylated tau may help protect the brain from infection

One of the main proteins that contributes to Alzheimer's disease is called phospho-tau (p-tau). When p-tau gets too many phosphate groups attached to it (a process called hyperphosphorylation), it starts to stick together and form clumps called "tangles" inside of brain nerve cells.

17 Dec 2025

Urine-based microRNA clock predicts biological aging without a blood test

Researchers developed and validated a non-invasive urinary microRNA aging clock using extracellular vesicle miRNAs from more than 6,000 adults. The model predicts age with about 4 to 5 years error and links accelerated aging signals to type 2 diabetes.

16 Dec 2025