Clinical Trial News and Research

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Study examines effectiveness of BNT162b2 vaccine against Delta variant in adolescents

The Clalit Research Institute, in collaboration with researchers from Harvard University, analyzed one of the world's largest integrated health record databases to examine the effectiveness of the Pfizer/BioNTech BNT162B2 vaccine against the Delta variant of SARS-CoV-2 among adolescents.

22 Oct 2021

NUS scientists develop a smart bandage to monitor chronic wounds

A research team led by Professor Lim Chwee Teck from the National University of Singapore's Department of Biomedical Engineering and Institute for Health Innovation & Technology, in collaboration with clinical partners from Singapore General Hospital, has developed a smart wearable sensor that can conduct real-time, point-of-care assessment of chronic wounds wirelessly via an app.

21 Oct 2021

Novel trial uses a virtual village to treat HIV-associated loneliness

A new clinical trial designed by Maile Young Karris, MD, internal medicine physician and infectious disease specialist at UC San Diego Health, seeks to discover whether people living with HIV can benefit from emotional support offered by a virtual community, and from physical support and services delivered by community volunteers.

21 Oct 2021

Novel Einstein-developed strategy successfully suppresses HIV infections in mice

Armed with a novel strategy they developed for bolstering the body's immune response, scientists at Albert Einstein College of Medicine have successfully suppressed HIV infections in mice - offering a path to a functional cure for HIV and other chronic viral infections.

21 Oct 2021

Antidepressant Prozac could offer the first treatment for atrophic macular degeneration

An antidepressant best known as Prozac could offer the first treatment for the leading cause of blindness among people over 50, new research from the University of Virginia School of Medicine suggests.

21 Oct 2021

Interferon treatment coupled with bone marrow transplant reduces risk of leukemia recurrence

Researchers at the University of Michigan Health Rogel Cancer Center have identified a drug that, when given along with a bone marrow transplant, drops the risk of leukemia recurring by 20% among the high-risk patients.

21 Oct 2021

Oxford vaccine trial participants believe the COVID-19 vaccine must be a shared global good

National pride in the Oxford-AstraZeneca vaccine does not outweigh desire for global greater good, suggests study with trial participants.

21 Oct 2021

New shorter treatment regimen found to be safer, more effective at treating drug-resistant TB

A new all-oral six-month treatment regimen is safer and more effective at treating rifampicin-resistant tuberculosis (RR-TB) than the current accepted standard of care, according to results announced at the 52nd Union World Conference on Lung Health.

20 Oct 2021

Scientists search for cause of mysterious covid-related inflammation in children

Like most other kids with covid, Dante and Michael DeMaino seemed to have no serious symptoms.

20 Oct 2021

Cat bacteria likely to form the basis for novel therapeutics against severe skin infections

Researchers at University of California San Diego School of Medicine used bacteria found on healthy cats to successfully treat a skin infection on mice. These bacteria may serve as the basis for new therapeutics against severe skin infections in humans, dogs and cats.

20 Oct 2021

Collaborations and co-achievements of network of COST Actions on COVID-19

Addressing societal issues by enabling cross-disciplinary partnerships is an inherent part of a COST Actions' nature. But collaborations don't stop at the gate of these specific networks: multiple COST Actions have joined forces since the beginning of the pandemic to help advance research into COVID-19.

20 Oct 2021

New findings may help widen therapeutic interventions for B-cell acute lymphoblastic leukemia

A retrospective study led by Northwestern Medicine investigators found that the chimeric antigen receptor (CAR) T-cell immunotherapy drug tisagenlecleucel demonstrated safety and efficacy in pediatric patients with relapsed and refractory B-cell acute lymphoblastic leukemia (B-cell ALL), even when the drug doesn't meet the FDA's strict manufacturing standards.

19 Oct 2021

100% orange juice shows potential to help fight inflammation and oxidative stress

A new study suggests 100% orange juice has the potential to help fight inflammation and oxidative stress in adults, paving the way for further research on the topic.

19 Oct 2021

New ESMO Clinical Practice Guideline for managing metastatic breast cancer released

The much-anticipated ESMO Clinical Practice Guideline for the diagnosis, staging and treatment of patients with metastatic breast cancer has been published today in Annals of Oncology.

19 Oct 2021

The biochemical mechanisms of remdesivir-mediated RNA synthesis inhibition

A new preprint suggests a fruitful approach to develop such drugs based on biochemical and molecular modeling studies of the drug remdesivir.

19 Oct 2021

UChicago and Rush secure NIH grant to launch the Chicago Chronic Condition Equity Network

The University of Chicago and Rush University have received a $20M, five-year grant from the National Institutes of Health to establish a Center for Multiple Chronic Diseases Associated with Health Disparities.

18 Oct 2021

Researchers illustrate the importance and value of sharing negative research results

In the era of "publish or perish," research results that disprove the hypothesis tested often go unpublished. In addition, many researchers who have been unable to reproduce results from other laboratories have found it difficult to publish their findings.

18 Oct 2021

Interferon beta-1a plus remdesivir not superior to remdesivir alone in hospitalized COVID-19 patients

A clinical trial has found that treatment with the immunomodulator interferon beta-1a plus the antiviral remdesivir was not superior to treatment with remdesivir alone in hospitalized adults with COVID-19 pneumonia.

18 Oct 2021

Researchers report long-lasting effects of gene therapy in children with deadly immune disorder

Over a decade ago, UCLA physician-scientists began using a pioneering gene therapy they developed to treat children born with a rare and deadly immune system disorder.

18 Oct 2021

Mix-and-match booster shots beneficial in boosting SARS-CoV-2 immunity

Should you get a second dose of the same vaccine if you’ve received the one-dose Johnson & Johnson shot? According to new clinical trial results published on the preprint medRxiv* server, a booster shot of a messenger RNA (mRNA) vaccine may increase your chances of neutralizing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

17 Oct 2021

Clinical Trial News and Research

Study examines effectiveness of BNT162b2 vaccine against Delta variant in adolescents

NUS scientists develop a smart bandage to monitor chronic wounds

Novel trial uses a virtual village to treat HIV-associated loneliness

Novel Einstein-developed strategy successfully suppresses HIV infections in mice

Antidepressant Prozac could offer the first treatment for atrophic macular degeneration

Interferon treatment coupled with bone marrow transplant reduces risk of leukemia recurrence

Oxford vaccine trial participants believe the COVID-19 vaccine must be a shared global good

New shorter treatment regimen found to be safer, more effective at treating drug-resistant TB

Scientists search for cause of mysterious covid-related inflammation in children

Cat bacteria likely to form the basis for novel therapeutics against severe skin infections

Collaborations and co-achievements of network of COST Actions on COVID-19

New findings may help widen therapeutic interventions for B-cell acute lymphoblastic leukemia

100% orange juice shows potential to help fight inflammation and oxidative stress

New ESMO Clinical Practice Guideline for managing metastatic breast cancer released

The biochemical mechanisms of remdesivir-mediated RNA synthesis inhibition

UChicago and Rush secure NIH grant to launch the Chicago Chronic Condition Equity Network

Researchers illustrate the importance and value of sharing negative research results

Interferon beta-1a plus remdesivir not superior to remdesivir alone in hospitalized COVID-19 patients

Researchers report long-lasting effects of gene therapy in children with deadly immune disorder

Mix-and-match booster shots beneficial in boosting SARS-CoV-2 immunity

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