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How does SARS-CoV-2 infect brain cells?

Researchers from the University of California San Francisco, Gladstone Institutes in the USA, and The Aga Khan University in Pakistan investigated if human neural cells can be infected by SARS-CoV-2.

20 Jan 2021

Can metabolic biomarkers help clinicians stratify adverse outcome risk in COVID-19 patients?

A recent study describes the alterations in lipids and other parameters that define the state of dysfunctional metabolism in acute COVID-19 illness.

20 Jan 2021

Researchers develop new method for charting SARS-CoV-2 spike protein glycosylation

Researchers develop a novel, simple and affordable method for N-glycan fingerprinting based on enzymatic fluorescent glycan labeling and electrophoresis. This new method may help us understand important changes in glycosylation in the SARS-CoV-2 spike protein – something which could inform future therapeutic research.

20 Jan 2021

Bacteria responsible for seafood-related stomach upsets can go dormant and "wake up"

Scientists have discovered how bacteria commonly responsible for seafood-related stomach upsets can go dormant and then "wake up".

20 Jan 2021

Over 100 million in India may have been infected by SARS-CoV-2

A large new study posted on the preprint server medRxiv describes the seropositivity rate to this virus, as well as the persistence of antibodies over time, both neutralizing and others.

19 Jan 2021

Scientists uncover elusive mechanism behind the most severe cases of blood disorder

With a name like glucose-6-phosphate dehydrogenase deficiency, one would think it is a rare and obscure medical condition, but that's far from the truth.

19 Jan 2021

Mapping antibody reactivity in COVID-19 patients by using multi-coronavirus protein microarray

In an exciting, state-of-the-art study currently available on the medRxiv* preprint server, US researchers created a multi-coronavirus protein microarray containing full-length proteins, peptide libraries, and overlapping protein fragments from the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), as well as four other human coronaviruses.

19 Jan 2021

Study explores how choice of foods influences aging and lifespan in fruit flies

Having a choice of foods may accelerate aging and shorten the lifespan of fruit flies, according to a study published today in the open-access eLife journal.

19 Jan 2021

Gene-cutting system may play second role as a genetic dimmer switch

In a series of experiments with laboratory-cultured bacteria, Johns Hopkins scientists have found evidence that there is a second role for the widely used gene-cutting system CRISPR-Cas9 -- as a genetic dimmer switch for CRISPR-Cas9 genes.

19 Jan 2021

Lower CD4 T cell reactivity to seasonal coronaviruses found in healthcare workers with COVID-19

A new study by US-based researchers describes the results of a study on the immune response among healthcare workers, in particular, their T cell responses predating the pandemic.

19 Jan 2021

Large study finds SARS-CoV-2 viral load is lowest in children

A new study by researchers in the Netherlands confirms the hypothesis that for SARS-CoV-2 infection, higher age is associated with increased viral loads.

19 Jan 2021

Scientists develop world's first test to accurately predict mood disorders

University of South Australia scientists have developed the world's first test to accurately predict mood disorders in people, based on the levels of a specific protein found in the brain.

19 Jan 2021

Researchers find potential biomarkers of Parkinson's disease

A research team led by Nagoya University in Japan has found that blood pressure, the hematocrit (the percentage of red blood cells in blood), and serum cholesterol levels change in patients with Parkinson's disease long before the onset of motor symptoms.

18 Jan 2021

Closed SARS-CoV-2 spikes could be a valuable component of future vaccines

Now, researchers at the Medical Research Council Laboratory of Molecular Biology, Cambridge, United Kingdom, reveal that engineered closed S constructs may be valuable immunogens that can induce neutralizing antibodies against a different pattern of epitopes. This allows for the flexibility of vaccines at both the individual and population levels.

18 Jan 2021

Research suggests seaweed used in traditional Chinese medicine could protect against COVID-19

Researchers in China have conducted a study showing that a carbohydrate found in the seaweed Ecklonia kurome blocks the activity of an enzyme that is essential for the replication of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) – the agent that causes coronavirus disease 2019 (COVID-19).

18 Jan 2021

Two common blood pressure drugs are not tied to increased risk of COVID-19

Research published in the peer-reviewed journal The Lancet Digital Health and co-led by a UCLA Fielding School of Public Health faculty member has found that two widely used types of blood pressure drugs are not tied to an increased risk of COVID-19 infection or complications.

18 Jan 2021

Modified natural killer cells show neutralizing and multivalent potential against SARS-CoV-2 in vitro

A new study suggests that modified natural killer cells, which express a chimeric antigen receptor using S309 antibody, can bind to and inactivate SARS-CoV-2 spike protein in vitro.

18 Jan 2021

Can transgenic mice studies illuminate neurological complications associated with SARS-CoV-2 in humans?

The potentially deadly COVID-19 has not affected animals with corresponding severity. To understand the mechanism of severe disease, animal models have been used. This includes a mouse model that expresses human angiotensin-converting enzyme 2 (hACE2) under the cytokeratin 18 promoter (K18-hACE2). A new study indicates that this may not be a faithful model of human lethal infection with SARS-CoV-2.

18 Jan 2021

New SARS-CoV-2 variant emerges in the U.S.

Even as the rollout of vaccines all over the world brings a glimmer of hope that the current coronavirus disease 2019 (COVID-19) pandemic may end in the near future, new variants continue to emerge, some with the potential to escape vaccine-induced or therapeutic antibodies. Now, a new preprint research paper published on the bioRxiv server describes a new American variant that may have become the dominant strain in the USA.

18 Jan 2021

SARS-CoV-2 anti-N rigid monoclonal antibodies provide accurate early diagnosis

An interesting new preprint research paper that was posted on the bioRxiv* server recently describes the use of rigid monoclonal antibodies (mAbs) in contrast to flexible mAbs, and how this affects the binding of multiple mAbs to the same antigen.

17 Jan 2021

Enzyme News and Research

How does SARS-CoV-2 infect brain cells?

Can metabolic biomarkers help clinicians stratify adverse outcome risk in COVID-19 patients?

Researchers develop new method for charting SARS-CoV-2 spike protein glycosylation

Bacteria responsible for seafood-related stomach upsets can go dormant and "wake up"

Over 100 million in India may have been infected by SARS-CoV-2

Scientists uncover elusive mechanism behind the most severe cases of blood disorder

Mapping antibody reactivity in COVID-19 patients by using multi-coronavirus protein microarray

Study explores how choice of foods influences aging and lifespan in fruit flies

Gene-cutting system may play second role as a genetic dimmer switch

Lower CD4 T cell reactivity to seasonal coronaviruses found in healthcare workers with COVID-19

Large study finds SARS-CoV-2 viral load is lowest in children

Scientists develop world's first test to accurately predict mood disorders

Researchers find potential biomarkers of Parkinson's disease

Closed SARS-CoV-2 spikes could be a valuable component of future vaccines

Research suggests seaweed used in traditional Chinese medicine could protect against COVID-19

Two common blood pressure drugs are not tied to increased risk of COVID-19

Modified natural killer cells show neutralizing and multivalent potential against SARS-CoV-2 in vitro

Can transgenic mice studies illuminate neurological complications associated with SARS-CoV-2 in humans?

New SARS-CoV-2 variant emerges in the U.S.

SARS-CoV-2 anti-N rigid monoclonal antibodies provide accurate early diagnosis

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