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Insights into molecular tools shared across coronaviruses could provide potential target for COVID-19

Coronaviruses exploit our cells so they can make copies of themselves inside us. After they enter our cells, they use our cell machinery to make unique tools of their own that help them generate these copies.

22 Feb 2021

Researchers uncover 'hotspots' on the Spike protein that are critical for SARS-CoV-2 infection

The COVID-19 pandemic has prompted considerable investigation into how the SARS-CoV-2 Spike protein attaches to a human cell during the infection process, as this knowledge is useful in designing vaccines and therapeutics.

22 Feb 2021

FDA issues guidance for medical product developers to address the emergence of SARS-CoV-2 variants

Today, the U.S. Food and Drug Administration issued guidances for medical product developers, specifically covering vaccines, diagnostics and therapeutics products, to address the emergence and potential future emergence of variants of SARS-CoV-2, the virus that causes COVID-19.

22 Feb 2021

Superspreader events trigger emergence of novel SARS-CoV-2 variants in USA

A team of scientists from the USA and Germany has recently studied the evolution of SARS-CoV-2 in a representative set of sequences from the USA collected between 2020 and 2021. The findings reveal that the viral genome has accumulated multiple mutations over time with only occasional loss of mutation. The main driving forces behind such genetic variations include widespread infection and superspreader events.

22 Feb 2021

Cissampelos pareira L. extracts demonstrate anti-SARS-CoV-2 activity in vitro

A team of scientists from India has recently investigated the antiviral potency of a traditional medicinal plant Cissampelos pareira L. in preventing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. The findings reveal that both whole-plant extracts and bioactive compounds can inhibit SARS-CoV-2 replication by modulating estrogen receptor 1 (ESR1) activity.

21 Feb 2021

Transforming immune killer T-cells into 'super soldiers' to fight against cancer

Creating "super soldiers" of specific white blood cells to boost an anti-tumour response has been shown in a series of elegant experiments by Princess Margaret researchers.

20 Feb 2021

How does the SARS-CoV-2 E484K mutation increase viral fitness?

How do mutations benefit SARS-CoV-2? To explore this, a team of researchers from China took a closer look at the physical interactions that occur between the proteins after viral mutation.

19 Feb 2021

Understanding the dynamics of brain blood flow could hold key for treating neurologic conditions

While the human brain has over 400 miles of total vasculature, little is known about the tiny capillaries that make up much of this intricate labyrinth of blood vessels critical for delivering oxygenated blood and nutrients to billions of brain cells.

19 Feb 2021

Researchers discover potential new way to target pancreatic tumors with high IFN signaling

UCLA Jonsson Comprehensive Cancer Center researchers have uncovered a potential new way to target pancreatic tumors that express high intratumoral interferon signaling (IFN).

18 Feb 2021

Analyzing short strands of cell-free DNA in urine could help detect early-stage cancer

Urinalysis has long been a staple of physical exams to detect and manage a number of diseases and disorders, but not cancer.

18 Feb 2021

Researchers evaluate frequency of SARS-CoV-2 in hematology/oncology settings

Researchers from Rutgers Cancer Institute of New Jersey, the state's only National Cancer Institute-designated Comprehensive Cancer Center, evaluated the frequency of SARS-CoV-2, the virus that causes COVID-19, on various environmental surfaces in outpatient and inpatient hematology/oncology settings located within Rutgers Cancer Institute and Robert Wood Johnson University Hospital, an RWJBarnabas Health facility.

18 Feb 2021

Are antibody cocktails the key to COVID-19 treatment?

News-Medical speaks to Dr. Natalia Freund about her latest research into COVID-19, and how most people are capable of producing neutralizing antibodies against the virus.

18 Feb 2021

Scientists reveal the structure of glutamate transporter in our cells

For the first time, researchers have found one of the most important molecular machines in our cells uses a ‘twisting elevator’ mechanism, solving a mystery of how it transports crucial chemical signals from one cell to another.

18 Feb 2021

New project to investigate how antibodies in breastmilk can protect babies from COVID-19

An investigation into how antibodies in breastmilk can protect babies and young children from COVID-19 will be the focus of a new project by The University of Western Australia, funded by the State Government to tackle health challenges associated with the virus.

18 Feb 2021

New diagnostic platform can rapidly measure COVID-19-related biomarkers

The Wyss Institute for Biologically Inspired Engineering at Harvard University and GBS Inc., a subsidiary of The iQ Group Global, announce that they will collaborate to validate and de-risk a specific and sensitive COVID-19 diagnostic that would integrate the Institute's eRapid technology with the company's proprietary transistor sensor technology to enable simultaneous electrochemical sensing of multiple biomarkers related to SARS-CoV-2 infection in point-of-care COVID-19 diagnostic applications.

18 Feb 2021

Researchers identify antibody that removes amyloid plaques without the risk of brain bleeds

As people age, a normal brain protein known as amyloid beta often starts to collect into harmful amyloid plaques in the brain. Such plaques can be the first step on the path to Alzheimer's dementia.

18 Feb 2021

Scientists reveal the shape of glutamate transporter in human cells

A University of Sydney-led international team of scientists has revealed the shape of one of the most important molecular machines in our cells the glutamate transporter, helping to explain how our brain cells communicate with one another.

18 Feb 2021

Nanotherapy shows potential for treating severe Crohn's disease

Scientists from the Stanley Manne Children's Research Institute at Ann & Robert H. Lurie Children's Hospital of Chicago demonstrated that a nanotherapy reduces intestinal inflammation and shrinks lesions in a rodent model of severe Crohn's disease.

17 Feb 2021

The origin of SARS-CoV-2 furin cleavage site remains a mystery

A new study discusses the origin of the furin cleavage site on the SARS-CoV-2 spike protein, which is responsible for the virus’s relatively high infectivity compared to relatives in the betacoronavirus subgenus.

17 Feb 2021

Scientists to develop highly sensitive antibody tests for infection caused by all coronaviruses

Scientists at the Center for Infection and Immunity (CII) at Columbia University Mailman School of Public Health and SunYat-Sen University in China have set the stage for the development of highly sensitive antibody tests for infection with all known human coronaviruses, including new variants of SARS-CoV-2.

17 Feb 2021

Therapeutics News and Research

Insights into molecular tools shared across coronaviruses could provide potential target for COVID-19

Researchers uncover 'hotspots' on the Spike protein that are critical for SARS-CoV-2 infection

FDA issues guidance for medical product developers to address the emergence of SARS-CoV-2 variants

Superspreader events trigger emergence of novel SARS-CoV-2 variants in USA

Cissampelos pareira L. extracts demonstrate anti-SARS-CoV-2 activity in vitro

Transforming immune killer T-cells into 'super soldiers' to fight against cancer

How does the SARS-CoV-2 E484K mutation increase viral fitness?

Understanding the dynamics of brain blood flow could hold key for treating neurologic conditions

Researchers discover potential new way to target pancreatic tumors with high IFN signaling

Analyzing short strands of cell-free DNA in urine could help detect early-stage cancer

Researchers evaluate frequency of SARS-CoV-2 in hematology/oncology settings

Are antibody cocktails the key to COVID-19 treatment?

Scientists reveal the structure of glutamate transporter in our cells

New project to investigate how antibodies in breastmilk can protect babies from COVID-19

New diagnostic platform can rapidly measure COVID-19-related biomarkers

Researchers identify antibody that removes amyloid plaques without the risk of brain bleeds

Scientists reveal the shape of glutamate transporter in human cells

Nanotherapy shows potential for treating severe Crohn's disease

The origin of SARS-CoV-2 furin cleavage site remains a mystery

Scientists to develop highly sensitive antibody tests for infection caused by all coronaviruses

Advancing therapeutic biopolymer development eBook

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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