Therapy News and Research

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A novel therapeutic option for HER2-positive extramammary Paget disease

The research article presents a comprehensive evaluation of the human epidermal growth factor receptor 2 (HER2) status in extramammary Paget disease (EMPD) and explores the therapeutic potential of disitamab vedotin (DV), a novel humanized anti-HER2 antibody-drug conjugate (ADC), for this rare adenocarcinoma.

4 Sep 2024

Alirocumab reduces dangerous coronary plaque and stabilizes high-risk lesions

Intensive LDL-C lowering with alirocumab significantly reduces high-risk coronary plaque burden, transforming unstable plaques into more stable phenotypes. This lesion-level analysis underscores the enhanced efficacy compared to vessel-level approaches.

4 Sep 2024

AI model enhances detection of immune-related adverse events in cancer patients

While immune checkpoint inhibitors (ICIs) can provide lifesaving treatment for patients with cancer, they have also been found to cause immune-related adverse events (irAEs) - side effects that can impact almost every organ in the body to varying degrees.

3 Sep 2024

Ketamine clinics show inconsistent practices on pregnancy and contraception

More hospitals and clinics now offer patients ketamine therapy for severe depression, post-traumatic stress disorder and other mental health conditions that haven't responded to other treatments.

3 Sep 2024

RNA Therapeutics Core launches at Mass General Brigham to boost circular RNA research

The Mass General Brigham Gene and Cell Therapy Institute (GCTI) today announced it has launched the RNA Therapeutics Core, a first-of-its-kind, state-of-the-art facility and resource to advance the use of RNA technologies within and beyond the Mass General Brigham research ecosystem.

3 Sep 2024

Penn research uncovers key biomarker for diagnosing sarcoidosis

Sarcoidosis is a rare systemic disease that afflicts an estimated 200,000 people in the US, more often people who are Black and more women than men, particularly when it causes chronic skin disease.

3 Sep 2024

Researchers develop stable compound for targeted alpha therapy in prostate cancer

Compounds containing astatine-211 (211At) can be used in targeted radiotherapies for prostate cancer, but deastatination in the body remains a significant hurdle.

3 Sep 2024

Study shows beta cells can function independently for glycemic control

Our glycemic balance is based on the ability of the pancreatic beta cells to detect glucose and secrete insulin to maintain our blood sugar levels. If these cells malfunction, the balance is broken, and diabetes develops.

3 Sep 2024

Hormonal treatment could delay biological aging among postmenopausal females

Hormone treatment in postmenopausal women is associated with lower biological aging discrepancies, particularly among those with lower socioeconomic status.

3 Sep 2024

Matcha green tea enhances cognition and sleep in older adults

Regular matcha green tea consumption may improve emotional perception and sleep quality in older adults with cognitive decline, though it shows no significant effect on broader cognitive functions.

2 Sep 2024

$FINEARTS-HF trial shows finerenone benefits for heart failure with preserved ejection fraction$

FINEARTS-HF trial shows finerenone benefits for heart failure with preserved ejection fraction

Finerenone reduced heart failure (HF) events and cardiovascular death in patients with HF and mildly reduced (HFmrEF) or preserved ejection fraction (HFpEF), according to late-breaking research presented in a Hot Line session today at ESC Congress 2024.

2 Sep 2024

Wearable heart monitor for AF screening increases diagnoses but not stroke prevention

Screening for atrial fibrillation (AF) using a wearable heart monitor for 2 weeks can identify older adults with this potentially dangerous abnormal heart rhythm, but does not prevent subsequent strokes, according to late breaking research presented in a Hot Line Session at this year's ESC Congress 2024 in London, UK (30 Aug - 2 Sept).

2 Sep 2024

Village doctor-led telemedicine reduces cardiovascular events in rural China

Telemedicine support to village doctors could hold the key to improving access to care for China's rural elderly at risk for developing potentially life-threatening complications resulting from untreated atrial fibrillation, according to late breaking research presented in a Hot Line Session at this year's ESC Congress 2024 in London, UK (30 Aug - 2 Sept).

2 Sep 2024

Invasive strategy shows no benefit in cardiovascular death reduction for older NSTEMI patients

An invasive strategy vs. optimal medical therapy alone after a non-ST-elevation myocardial infarction (NSTEMI) in older adults did not affect the combined risk of cardiovascular death or MI, although non-fatal MIs and subsequent revascularisation procedures were reduced, according to late-breaking research presented in a Hot Line session today at ESC Congress 2024.

2 Sep 2024

Breakthrough in blood stem cell development offers hope for leukemia and bone marrow failure

Melbourne researchers have made a world first breakthrough into creating blood stem cells that closely resemble those in the human body. And the discovery could soon lead to personalized treatments for children with leukemia and bone marrow failure disorders.

2 Sep 2024

New method revolutionizes DNA-encoded chemical libraries

Nowadays, there's lots of buzz about spectacular new medical treatments such as personalised cancer therapy with modified immune cells or antibodies.

2 Sep 2024

$Finerenone shows promise for heart failure with mildly reduced or preserved ejection fraction$

Finerenone shows promise for heart failure with mildly reduced or preserved ejection fraction

Finerenone reduced the composite of total first and recurrent heart failure (HF) events (hospitalizations for HF or urgent HF visits) and cardiovascular death in patients with HF and mildly reduced or preserved ejection fraction, according to an international clinical trial led by investigators from Brigham and Women's Hospital, a founding member of the Mass General Brigham healthcare system.

2 Sep 2024

Edoxaban monotherapy superior to dual therapy in patients with high-risk AF and stable CAD

Edoxaban monotherapy reduced net adverse clinical events compared with edoxaban plus a single antiplatelet agent, when used as long-term antithrombotic therapy, in patients with high-risk atrial fibrillation (AF) and stable coronary artery disease (CAD), according to late-breaking research presented in a Hot Line session today at ESC Congress 2024.

1 Sep 2024

OCEANIC-AF trial reveals inferiority of asundexian to apixaban for stroke prevention

Asundexian 50 mg daily was inferior to apixaban for stroke and systemic embolism prevention in high-risk patients with atrial fibrillation (AF), according to late-breaking research presented in a Hot Line session today at ESC Congress 2024.

1 Sep 2024

New study confirms safety of SGLT2 inhibitors after acute myocardial infarction

The SGLT2 inhibitor empagliflozin confers kidney-protective benefits and can therefore be given safely and effectively to patients when they are hospitalized for acute myocardial infarction (MI), a Mount Sinai-led global team of researchers has shown.

1 Sep 2024

Therapy News and Research

A novel therapeutic option for HER2-positive extramammary Paget disease

Alirocumab reduces dangerous coronary plaque and stabilizes high-risk lesions

AI model enhances detection of immune-related adverse events in cancer patients

Ketamine clinics show inconsistent practices on pregnancy and contraception

RNA Therapeutics Core launches at Mass General Brigham to boost circular RNA research

Penn research uncovers key biomarker for diagnosing sarcoidosis

Researchers develop stable compound for targeted alpha therapy in prostate cancer

Study shows beta cells can function independently for glycemic control

Hormonal treatment could delay biological aging among postmenopausal females

Matcha green tea enhances cognition and sleep in older adults

FINEARTS-HF trial shows finerenone benefits for heart failure with preserved ejection fraction

Wearable heart monitor for AF screening increases diagnoses but not stroke prevention

Village doctor-led telemedicine reduces cardiovascular events in rural China

Invasive strategy shows no benefit in cardiovascular death reduction for older NSTEMI patients

Breakthrough in blood stem cell development offers hope for leukemia and bone marrow failure

New method revolutionizes DNA-encoded chemical libraries

Finerenone shows promise for heart failure with mildly reduced or preserved ejection fraction

Edoxaban monotherapy superior to dual therapy in patients with high-risk AF and stable CAD

OCEANIC-AF trial reveals inferiority of asundexian to apixaban for stroke prevention

New study confirms safety of SGLT2 inhibitors after acute myocardial infarction

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

The impact of vibration on microscopy

How Omics Technologies Are Transforming Biological Research and Drug Discovery

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