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New clue to protect neurons and encourage their growth found

Many neurodegenerative conditions, from glaucoma to Alzheimer's disease, are characterized by injury to axons - the long, slender projections that conduct electrical impulses from one nerve cell to another, facilitating cellular communications. Injury to axons often leads to neuronal impairment and cell death.

14 Dec 2020

D614G mutation promotes lysosomal trafficking of SARS-CoV-2 spike protein

In the current COVID-19 pandemic, SARS-CoV-2 has led to millions of infections worldwide, with over 1.5 million deaths.

14 Dec 2020

SARS-CoV-2 Nsp3 protease activity and nanobody inhibitor development

A new study published in the pre-print server bioRxiv* explores the viral enzyme PLpro, encoded in the nonstructural protein nsp3, and its inhibitors. T

14 Dec 2020

Active enzyme needed to unlock full benefits of vitamin A in carrots

Carrots are a good source of beta-carotene, which is a precursor of vitamin A. But to get the full health benefits of this superfood, you need an active enzyme to produce this vitamin.

11 Dec 2020

Study identifies protein as potential therapeutic target for leishmaniasis vaccines

According to the results of research led by the Complutense University of Madrid (UCM), one the various strategies deployed by the Leishmania parasite to avoid triggering the human immune system is to activate the SHP-1 protein.

11 Dec 2020

Vitamin D deficiency could explain why autism spectrum disorder is more common in boys

A deficiency in Vitamin D on the mother's side could explain why Autism spectrum disorder is three times more common in boys, say researchers from The University of Queensland.

11 Dec 2020

Saliva-based smartphone COVID-19 testing platform provides results within 15 minutes

Offering an ultrasensitive yet accessible approach to COVID-19 testing, a portable saliva-based smartphone platform provides results within 15 minutes without the resource-intensive laboratory tests the current gold standard requires, according to a new study.

11 Dec 2020

Distant residues modulate the conformational opening in SARS-CoV-2 spike protein

Scientists present an insight into the RBD dynamics with physically distant residues in the spike protein, elaborating on the importance of predicted mutations for therapeutics.

11 Dec 2020

COVID-19 infection may also affect the central nervous system, cause neurological disorders

COVID-19 is known primarily as a respiratory disease, with symptoms that include cough, shortness of breath, and, in severe cases, acute respiratory distress syndrome and pneumonia

10 Dec 2020

MEDS433 hinders SARS-CoV-2 replication

A paper that recently appeared in the preprint server bioRxiv* reports the powerful activity of a compound named MEDS433 against this virus.

10 Dec 2020

SARS-CoV-2 spike protein mediates acute lung pathology in mice

A study shows that the viral spike protein is adequate by itself to induce macrophage activation in pulmonary tissue and induce acute inflammation.

10 Dec 2020

Researchers develop new serological assay for detection of SARS-CoV-2 antibodies

Researchers at UC Santa Cruz have developed a novel serological assay for the detection of antibodies to SARS-CoV-2, the coronavirus that causes COVID-19.

10 Dec 2020

Research presents potential therapeutic strategy for reducing age-related diseases

Research findings by a KAIST team provide insight into the complex mechanism of cellular senescence and present a potential therapeutic strategy for reducing age-related diseases associated with the accumulation of senescent cells.

10 Dec 2020

Recommended biomarker screening is highly underutilized, shows study

About five percent of patients experience heart muscle injury around the time of their surgery for a noncardiac condition, yet guideline recommendations to identify patients at risk using biomarkers are not being followed.

10 Dec 2020

EKF launches high performance quantitative COVID-SeroKlir antibody test kit

EKF Diagnostics, the global in vitro diagnostics company, announces that it has introduced one of the first tests to precisely measure levels of COVID-19 neutralizing antibodies in individuals.

From EKF Diagnostics 10 Dec 2020

Colon lining releases hydrogen peroxide to protect the body from gut microbes

Scientists at UC Davis Health have discovered that an enzyme in the colon lining releases hydrogen peroxide (H2O2) - a known disinfecting compound- to protect the body from gut microbes.

9 Dec 2020

Researchers identify new therapeutic target to treat patients with type 1 diabetes

Researchers at the University of Utah School of Medicine have identified a new therapeutic target to treat patients with type 1 diabetes.

9 Dec 2020

Study suggests vast majority of Seattle population remains susceptible to COVID-19

Researchers in the United States have conducted a study suggesting that a small proportion of people living in Seattle were infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) – the agent that causes coronavirus disease 2019 (COVID-19) – by around late March/early April 2020.

9 Dec 2020

Different SARS-CoV-2 neutralization assays are reliable and concordant for antibody monitoring

A recent study by US researchers, currently available on the medRxiv preprint server, evaluated several cell-based assays that are under validation for determining correlates of protection in individuals with symptomatic coronavirus disease (COVID-19) and vaccine studies – and demonstrated their high concordance with both live and pseudotyped virions.

9 Dec 2020

The effects of cigarette smoke and COPD on SARS-CoV-2 infection

Researchers have revealed some of the effects of cigarette smoke and chronic obstructive pulmonary disease (COPD) on SARS-CoV-2 infection.

9 Dec 2020

Enzyme News and Research

New clue to protect neurons and encourage their growth found

D614G mutation promotes lysosomal trafficking of SARS-CoV-2 spike protein

SARS-CoV-2 Nsp3 protease activity and nanobody inhibitor development

Active enzyme needed to unlock full benefits of vitamin A in carrots

Study identifies protein as potential therapeutic target for leishmaniasis vaccines

Vitamin D deficiency could explain why autism spectrum disorder is more common in boys

Saliva-based smartphone COVID-19 testing platform provides results within 15 minutes

Distant residues modulate the conformational opening in SARS-CoV-2 spike protein

COVID-19 infection may also affect the central nervous system, cause neurological disorders

MEDS433 hinders SARS-CoV-2 replication

SARS-CoV-2 spike protein mediates acute lung pathology in mice

Researchers develop new serological assay for detection of SARS-CoV-2 antibodies

Research presents potential therapeutic strategy for reducing age-related diseases

Recommended biomarker screening is highly underutilized, shows study

EKF launches high performance quantitative COVID-SeroKlir antibody test kit

Colon lining releases hydrogen peroxide to protect the body from gut microbes

Researchers identify new therapeutic target to treat patients with type 1 diabetes

Study suggests vast majority of Seattle population remains susceptible to COVID-19

Different SARS-CoV-2 neutralization assays are reliable and concordant for antibody monitoring

The effects of cigarette smoke and COPD on SARS-CoV-2 infection

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