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Uncovering the Structure of HIV Integrase to Inform Drug Discovery

In this interview Dr Kushol Gupta, Research Assistant Professor in the Department of Biochemistry and Biophysics at the Perelman School of Medicine, University of Pennsylvania talks to News-Medical and Life Sciences about the importance of light scattering techniques for investigating structure and mechanism of action in his ongoing research into HIV integrase and the development of HIV therapeutics.

From Waters | Wyatt Technology 24 Apr 2019

Scientists identify rare, paradoxical response to antiretroviral therapy

Antiretroviral therapy is usually very effective at suppressing HIV in the body, allowing a person's immune system to recover by preventing the virus from destroying CD4+ T cells.

19 Apr 2019

Breakthrough antibody treatment suppresses HIV without antivirals

A new research paper describes how an antibody that prevents HIV binding to human immune cells was shown to be able to suppress levels of HIV for up to four months.

18 Apr 2019

FDA approves two-drug complete regimen for previously untreated HIV-infected adults

The U.S. Food and Drug Administration today approved Dovato (dolutegravir and lamivudine), as a complete regimen for the treatment of human immunodeficiency virus type 1 (HIV-1) infection in adults with no antiretroviral treatment history and with no known or suspected substitutions associated with resistance to the individual components of Dovato.

9 Apr 2019

Novel models and strategies for TB detection, elimination, and care

This week, publication of a special issue on tuberculosis begins in PLOS Medicine, advised by guest editors Richard Chaisson of Johns Hopkins University, Claudia Denkinger of the University of Heidelberg, and Mark Hatherill of the South African Tuberculosis Vaccine Institute.

8 Apr 2019

New HIV drug that is like a "Swiss Army knife of immunotherapies"

HIV is a tricky virus that causes a unique phenomenon where the virus hides within the immune cells of patients when they are on treatment with the antiretroviral therapy (ART) drugs. When they are off the drugs, the virus comes back.

7 Apr 2019

Timed vaginal insemination can be safe, effective way to help HIV-affected couples conceive

Women with HIV were once advised against having children for fear that the infection could be passed on to their babies.

5 Apr 2019

New all-in-one immunotherapy approach kicks out hiding HIV and also kills it

In a first on the quest to cure HIV, University of Pittsburgh Graduate School of Public Health scientists report today in EBioMedicine that they've developed an all-in-one immunotherapy approach that not only kicks HIV out of hiding in the immune system, but also kills it.

4 Apr 2019

MUSC study provides evidence for link between 'leaky gut' and autoantibody production in HIV-positive patients

Human immunodeficiency virus, or HIV, attacks the immune system, making affected individuals more susceptible to infections. When patients with HIV are treated with antiretroviral therapy, their immune system can recover, but some of them produce self-destructive proteins, or autoantibodies.

2 Apr 2019

Depression symptoms associated with death among patients with HIV infection

In a new study to investigate the relationship among depressive disorders or symptoms, HIV status and mortality, researchers report that symptoms of depression are moderately associated with death among Veterans with HIV but not among those without HIV infection.

2 Apr 2019

Johns Hopkins surgeons perform first-ever living donor HIV-to-HIV kidney transplant

For the first time, a person living with HIV has donated a kidney to a transplant recipient also living with HIV. A multidisciplinary team from Johns Hopkins Medicine completed the living donor HIV-to-HIV kidney transplant on Mar. 25. The doctors say both the donor and the recipient are doing well.

29 Mar 2019

Columbia receives award for piloting Opioid Education and Naloxone Training on College Campuses

Rachel Shelton, ScD, MPH, Columbia Mailman School of Public Health assistant professor of Sociomedical Sciences, and Lisa Rosen-Metsch, PhD, dean of Columbia University's School of General Studies, received a planning grant award to focus on piloting Opioid Education and Naloxone Training on College Campuses.

29 Mar 2019

Privacy concerns prevent men from getting tested and treated for HIV

Privacy concerns linked to both health facilities and providers are major barriers to increasing the number of men who are tested and treated for HIV in Cote d'Ivoire, suggests new Johns Hopkins Center for Communication Programs research. CCP is based at the Johns Hopkins Bloomberg School of Public Health.

26 Mar 2019

Exposure to HIV virus, antiretroviral therapy before birth linked to obesity and asthma-like symptoms

Teens and young adults who were exposed to HIV and antiretroviral therapy before birth but are HIV-negative themselves are at increased risk of obesity and asthma-like symptoms, according to research to be presented Saturday, March 23 at ENDO 2019, the Endocrine Society's annual meeting in New Orleans, La.

25 Mar 2019

Naltrexone implant more effective in reducing relapses in HIV patients with opioid addiction

When patients with HIV who are also battling opioid dependence go without addiction treatment, they are more likely to stop taking their HIV medications than drug-free patients.

22 Mar 2019

Study finds high rate of viral suppression among people new to HIV care

Eighty-six percent of individuals who entered HIV care soon after diagnosis maintained viral suppression after 48 weeks during a clinical trial conducted at four National Institutes of Health-funded Centers for AIDS Research across the United States.

9 Mar 2019

HIV patients diagnosed with tuberculosis more likely to die within 10 years, study finds

Among people with HIV in Latin America, those diagnosed with tuberculosis at an initial clinic visit were about twice as likely to die within 10 years as people not initially diagnosed with TB, according to findings from a large observational study.

7 Mar 2019

Johns Hopkins researchers to present latest findings on TB and HIV at CROI 2019

Johns Hopkins Medicine researchers are attending the annual Conference on Retroviruses and Opportunistic Infections, where they are sharing their latest findings in the ongoing battle against HIV/AIDS and related infectious diseases with other top basic, translational and clinical researchers from around the world.

7 Mar 2019

Up-to-date guidance for clinicians to treat HIV-related cardiovascular disease

Since the advent of effective antiretroviral therapy, human immunodeficiency virus infection has become more like a chronic illness.

5 Mar 2019

Latest anti-retroviral drug therapies offer powerful solution for HIV infection-associated frailty

Treatment of the HIV/AIDS epidemic has seen remarkable advancements with the advent of the latest anti-retroviral drug therapy and powerful tools to test for drug resistance, making the infection almost "undetectable" in patients who strictly comply with their medication therapy, a just-published perspective article by a clinical team at the University of Arizona College of Medicine - Tucson points out.

27 Feb 2019