Clinical Trial News and Research

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Convalescent plasma does not benefit high-risk COVID-19 outpatients with early symptoms, study shows

The final results of the Clinical Trial of COVID-19 Convalescent Plasma in Outpatients (C3PO) demonstrate that COVID-19 convalescent plasma did not prevent disease progression in a high-risk group of outpatients with COVID-19, when administered within the first week of their symptoms.

18 Aug 2021

The White House says boosters for all. Here’s what you need to know.

The Biden administration announced plans Wednesday to offer boosters to all U.S. adults as soon as next month, saying that recent data, including some made available only in the past few days, played a role in that decision.

18 Aug 2021

Rush to boosters sparks confusion, differing recommendations

When the Food and Drug Administration announced last week that a third dose of Moderna or Pfizer-BioNTech covid-19 vaccine may boost the immunity of some people who are immunocompromised, officials repeated their stance that fully vaccinated, healthy people do not need another dose.

18 Aug 2021

Federal vaccine program hasn’t helped those whose lives were altered by covid shot

Angela Marie Wulbrecht jumped at the first chance to get a covid-19 vaccine, driving three hours from her Santa Rosa, California, home to a mass-vaccination site on Jan. 19.

18 Aug 2021

New bioengineered lung model could help scientists to advance research in lung conditions

An interdisciplinary team of researchers from McMaster and SickKids are developing a cutting-edge lung model that can better respond to viruses and drug treatments, giving scientists a tool to advance research in lung conditions like COVID-19, cystic fibrosis and allergens for asthma and air pollution.

18 Aug 2021

Study: Minority groups remain conspicuously absent from pancreatic cancer clinical trials

According to a study published today in Gastroenterology by researchers at Virginia Commonwealth University Massey Cancer Center and University of Florida Health, Black, Hispanic, Indigenous and Asian Americans remain conspicuously absent from pancreatic cancer clinical trials aimed at testing the most recent treatment advances for this deadly disease.

17 Aug 2021

Children’s Hospital Colorado helps prove safety and efficacy of CF treatment in younger pediatric patients

Researchers at the Children's Hospital Colorado Breathing Institute, the largest pediatric cystic fibrosis (CF) clinical care center in the U.S., participated in the pivotal international multi-center Phase 3 clinical trial, sponsored by Vertex Pharmaceuticals Incorporated, leading to FDA approval of TRIKAFTA (elexacaftor/tezacaftor/ivacaftor), a highly effective CF treatment, for patients ages 6 through 11 who have at least one copy of the F508del mutation.

17 Aug 2021

First-of-its-kind clinical trial network established in Asia to treat and prevent drug-resistant infections

Wellcome Trust has provided a grant of S$2.5 million to the National University of Singapore to establish the Asian Clinical Research Network to conduct antimicrobial clinical research to develop the most effective ways to treat and prevent life-threatening drug-resistant infections.

17 Aug 2021

New clinical trial investigates aspirin as part of new treatment for triple negative breast cancer

An innovative new study is trialing whether giving aspirin, commonly used as pain relief, alongside immunotherapy drug avelumab could improve its effectiveness for people affected by breast cancer.

17 Aug 2021

MGH researchers discover how triple-negative breast cancer can evade powerful drugs

Massachusetts General Hospital researchers have identified for the first time how a highly aggressive form of breast cancer can evade one of the most powerful and effective drugs used to treat it, reporting their findings in Cancer Discovery, a journal of the American Association for Cancer Research.

17 Aug 2021

Experimental drug and immunotherapy combination shows promise in bladder cancer study

A new study in mice found that adding the experimental drug entinostat to an immunotherapy-like treatment substantially boosted cancer remission.

16 Aug 2021

Combining inhibitor drug with immunotherapy agent improves response in cancer patients

Combining a histone deacetylase inhibitor drug with immunotherapy agents is safe, and may benefit some patients with advanced cancers that have not responded to traditional therapy, according to results of a phase 1 clinical trial led by researchers at the Johns Hopkins Kimmel Cancer Center, Bloomberg~Kimmel Institute for Cancer Immunotherapy and several other centers including University of Pittsburgh Cancer Institute, Yale Cancer Center and City of Hope in Los Angeles, which participated in study enrollment, and the University of Southern California and University College Cork in Ireland, which collaborated on analysis of the data.

16 Aug 2021

Excluding race factor from kidney function estimates may affect clinical outcomes for Black cancer patients

Removing race as a factor in a kidney function-estimating equation used to guide cancer treatment dosing and eligibility may decrease the proportion of Black patients recommended to receive full doses of anticancer drugs.

16 Aug 2021

World-first trial of third dose COVID-19 booster vaccine shows improved protection in transplant patients

Scientists with the Ajmera Transplant Centre at UHN have conducted a first-in-the-world randomized placebo-controlled trial of third dose COVID-19 booster vaccine for transplant patients that shows substantially improved protection.

14 Aug 2021

Study helps to clarify the post-clinical trial needs of cancer patients

Cancer clinical trials (CCTs) provide patients an opportunity to receive experimental drugs, tests, and/or procedures that can lead to remissions. For some, a CCT may seem like their only option. Yet little is known about the experiences of patient participants who withdraw from CCTs.

14 Aug 2021

UC Davis joins with Pfizer for COVID-19 booster vaccine trial

As COVID-19 booster shots begin for those with compromised immune systems, researchers at the UC Davis School of Medicine continue to collect data from clinical trial participants.

13 Aug 2021

Specific leukemia gene mutations exert divergent effects on DNA repair and sensitivity to PARP Inhibitors

In a recent study published in Cancer Research, researchers from Fels Cancer Institute for Personalized Medicine at the Lewis Katz School of Medicine at Temple University and Fox Chase Cancer Center identified specific leukemia gene mutations and the mechanisms by which they regulate DNA repair and respond to PARP inhibitors.

13 Aug 2021

Pfizer CEO to public: Just trust us on the covid booster

Pfizer CEO Albert Bourla was confident in June about the ability of his company's vaccine to protect against the highly contagious delta variant, as it marched across the globe and filled U.S. hospitals with patients.

13 Aug 2021

Nanotechnology may help improve treatment for colorectal cancer and melanoma

University of Arizona Health Sciences researchers recently completed a study that has the potential to improve cancer treatment for colorectal cancer and melanoma by using nanotechnology to deliver chemotherapy in a way that makes it more effective against aggressive tumors.

12 Aug 2021

FDA approves a new indication for chronic sleep disorder treatment

The U.S. Food and Drug Administration today approved a new indication for Xywav for idiopathic hypersomnia (IH) in adults.

12 Aug 2021

Clinical Trial News and Research

Convalescent plasma does not benefit high-risk COVID-19 outpatients with early symptoms, study shows

The White House says boosters for all. Here’s what you need to know.

Rush to boosters sparks confusion, differing recommendations

Federal vaccine program hasn’t helped those whose lives were altered by covid shot

New bioengineered lung model could help scientists to advance research in lung conditions

Study: Minority groups remain conspicuously absent from pancreatic cancer clinical trials

Children’s Hospital Colorado helps prove safety and efficacy of CF treatment in younger pediatric patients

First-of-its-kind clinical trial network established in Asia to treat and prevent drug-resistant infections

New clinical trial investigates aspirin as part of new treatment for triple negative breast cancer

MGH researchers discover how triple-negative breast cancer can evade powerful drugs

Experimental drug and immunotherapy combination shows promise in bladder cancer study

Combining inhibitor drug with immunotherapy agent improves response in cancer patients

Excluding race factor from kidney function estimates may affect clinical outcomes for Black cancer patients

World-first trial of third dose COVID-19 booster vaccine shows improved protection in transplant patients

Study helps to clarify the post-clinical trial needs of cancer patients

UC Davis joins with Pfizer for COVID-19 booster vaccine trial

Specific leukemia gene mutations exert divergent effects on DNA repair and sensitivity to PARP Inhibitors

Pfizer CEO to public: Just trust us on the covid booster

Nanotechnology may help improve treatment for colorectal cancer and melanoma

FDA approves a new indication for chronic sleep disorder treatment

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