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SARS-CoV-2 entry at the cell surface facilitated by trypsin

Exogenous trypsin treatment boosts SARS-CoV-2 infection in Vero E6 cells and promotes viral multiplication in cultured cells.

1 Feb 2022

Mutational analysis of SARS-CoV-2 main protease

A new study discussed the findings of a comprehensive mutational analysis of the main protease (Mpro) of SARS-CoV-2.

1 Feb 2022

Assessing the effects of booster vaccinations against SARS-CoV-2 Omicron variant

In a new study, researchers analyzed the effect of vaccine booster doses against the SARS-CoV-2 Omicron variant.

1 Feb 2022

Assessing the neutralizing ability of polyclonal antibody XAV-19 against SARS-CoV-2 Omicron variant

In a new study, a team of researchers assessed the neutralizing activity of XAV-19, a glyco-humanized polyclonal antibody derived from hyperimmunized animal hosts, against the SARS-CoV-2 Omicron variant.

1 Feb 2022

Impact of using AI to generate primers for detection of SARS-CoV-2 Omicron variant

In a new study, researchers designed artificial intelligence (AI)-based primers for the SARS-CoV-2 Omicron variant.

1 Feb 2022

Illustrating the structural diversity of SARS-CoV-2 Omicron spike

In a new study, a team of researchers used cryo-electron microscopy to determine the spike (S) structures of the SARS-CoV-2 Omicron variant to understand how the mutations that alter its primary sequence impact S conformation.

1 Feb 2022

Researchers explore natural SARS-CoV-2 infection in pet rabbits in France

In a new study, researchers reported the first evidence of natural SARS-CoV-2 infections among domestic rabbits in France.

1 Feb 2022

Exploring beta-coronavirus neutralization by vaccine-induced murine antibody WS6

In a new study, researchers evaluated the neutralizing antibody titers in mice vaccinated with messenger ribonucleic acid (mRNA) encoding SARS-CoV-2 spike (S) protein.

1 Feb 2022

Placental ACE2 shedding may block SARS-CoV-2 transmission to babies during pregnancy

While COVID-19 disease significantly impacts many pregnant women, the rates of transmission from mother to baby in pregnancy are very low.

31 Jan 2022

Study finds limited evidence for IL-1 blockers in treating COVID-19

Researchers assess the effectiveness and safety outcomes of interleukin-1 blocking agents in the treatment of COVID-19.

31 Jan 2022

Drugs derived from activated protein C may limit ischemia and reperfusion injury, study suggests

A University of South Florida Health preclinical study offers molecular insight into how activated protein C (APC) may improve aging patients' tolerance to reperfusion injury – a potentially adverse effect of treatment for ischemic heart disease.

31 Jan 2022

Study reveals potential mechanism for iron accumulation in the aging brain

Breakdowns in regulatory mechanisms cause iron to build up in the brain as organisms grow older, increasing oxidative stress and causing cellular damage, according to a Northwestern Medicine study published in the journal eLife.

31 Jan 2022

3C-like protease inhibitor clinical candidate, S-217622, as a treatment for SARS-CoV-2

In a new study, a team of researchers discovered S-217622, a non-covalent SARS-CoV-2 3C-like protease (3CLpro) inhibitor clinical candidate for the treatment of COVID-19.

31 Jan 2022

Nucleocapsid antigen found to be a sensitive biomarker for acute COVID-19 infection

In a new study, researchers found that nucleocapsid antigen in the blood (antigenemia) is a sensitive and specific biomarker for acute coronavirus disease 2019 infection.

31 Jan 2022

Prion-like domains in SARS-CoV-2 RBD and ACE2 play important functional roles in viral adhesion and entry

Scientists have recently detected and analyzed viral PrDs in the S protein of SARS-CoV-2, which are the novel regulators of virion assembly.

31 Jan 2022

Binding and conformational properties of the SARS-CoV spike protein and hACE2 complex

A new paper in the journal Molecules describes this in molecular terms, comparing SARS-CoV-2 with an earlier highly pathogenic coronavirus, SARS-CoV.

31 Jan 2022

Vaccine-induced immunological memory is similar for Omicron and Delta SARS-CoV-2 variants

A new study by Norwegian researchers suggests that vaccine-induced immunological memory and the activation of recall responses in the body yields similar coverage for Omicron and Delta variants of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The paper is currently available on the medRxiv* preprint server while it undergoes peer review.

31 Jan 2022

Research shows minks mimic severe COVID-19 symptoms, including ARDS

Minks may be a suitable animal model for testing severe COVID-19 infections, finds a recent bioRxiv* preprint study. While mice and ferrets are used in preclinical severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), there is currently no model specific to severe disease.

30 Jan 2022

COVID-19 vaccines elicit cross-reactive antibodies against endemic coronaviruses

Researchers study the interaction between immunity to endemic coronaviruses and SARS-CoV-2.

30 Jan 2022

Scientists evaluate zoonotic potential of NeoCoV, a coronavirus related to MERS-CoV

Researchers identify ACE2 as the functional receptor of the two close relatives of MERS-CoV, NeoCoV and PDF-2180-CoV, in bats.

30 Jan 2022

Receptor News and Research

SARS-CoV-2 entry at the cell surface facilitated by trypsin

Mutational analysis of SARS-CoV-2 main protease

Assessing the effects of booster vaccinations against SARS-CoV-2 Omicron variant

Assessing the neutralizing ability of polyclonal antibody XAV-19 against SARS-CoV-2 Omicron variant

Impact of using AI to generate primers for detection of SARS-CoV-2 Omicron variant

Illustrating the structural diversity of SARS-CoV-2 Omicron spike

Researchers explore natural SARS-CoV-2 infection in pet rabbits in France

Exploring beta-coronavirus neutralization by vaccine-induced murine antibody WS6

Placental ACE2 shedding may block SARS-CoV-2 transmission to babies during pregnancy

Study finds limited evidence for IL-1 blockers in treating COVID-19

Drugs derived from activated protein C may limit ischemia and reperfusion injury, study suggests

Study reveals potential mechanism for iron accumulation in the aging brain

3C-like protease inhibitor clinical candidate, S-217622, as a treatment for SARS-CoV-2

Nucleocapsid antigen found to be a sensitive biomarker for acute COVID-19 infection

Prion-like domains in SARS-CoV-2 RBD and ACE2 play important functional roles in viral adhesion and entry

Binding and conformational properties of the SARS-CoV spike protein and hACE2 complex

Vaccine-induced immunological memory is similar for Omicron and Delta SARS-CoV-2 variants

Research shows minks mimic severe COVID-19 symptoms, including ARDS

COVID-19 vaccines elicit cross-reactive antibodies against endemic coronaviruses

Scientists evaluate zoonotic potential of NeoCoV, a coronavirus related to MERS-CoV

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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