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Immunotherapy drugs trigger inflammatory arthritis in subset of cancer patients

Since doctors began treating cancer patients with immunotherapy drugs called checkpoint inhibitors nearly a decade ago, they have observed that a subset of these patients experience a side effect that clinically looks like inflammatory arthritis.

10 Nov 2020

Researchers identify factors that improve diagnosis of chronic nonbacterial osteomyelitis

Researchers have identified several factors that should help improve the diagnosis of chronic nonbacterial osteomyelitis (CNO), also known as chronic recurrent multifocal osteomyelitis (CRMO).

10 Nov 2020

HSS presents research related to rheumatology and orthopedic surgery at 2020 ACR annual meeting

At this year's American College of Rheumatology virtual meeting, Hospital for Special Surgery (HSS) presented exciting research related to rheumatology and orthopedic surgery.

10 Nov 2020

Researchers discover unique anti-cancer function for previously well-characterized protein

The development and progression of cancer is a complicated process that occurs when cells in the body grow out of control. Many different mechanisms and pathways that directly affect cell proliferation have been uncovered.

10 Nov 2020

New biomaterial significantly reduces scar formation following wounds

Researchers at UCLA, Duke University and other collaborating institutions have developed a biomaterial that may significantly reduce scar formation after wounding, leading to more effective skin healing.

10 Nov 2020

Researchers compare racial variations in unilateral versus bilateral knee replacement surgery

Disparities in unilateral knee replacement surgery have been well-documented, with lower utilization and higher complication rates among African American patients.

10 Nov 2020

Exosome-mediated mRNA delivery generates broad immune response to multiple SARS-CoV-2 proteins

Recently, researchers from The Johns Hopkins University School of Medicine, Baltimore, MD, USA, and Capricor Therapeutics, Inc., Beverly Hills, CA, USA, described a new approach to SARS-CoV-2 vaccine development using exosomes to deliver mRNAs that encode the antigens from multiple structural proteins of the virus.

9 Nov 2020

Aspirin to be tested as a potential COVID-19 treatment as part of RECOVERY trial

Now, in new research, the everyday painkiller aspirin will be evaluated as a potential treatment for COVID-19 in one of the United Kingdom’s most significant trials, aiming to evaluate whether it can reduce the risk of blood clots in infected people.

9 Nov 2020

Translational study within SARS-CoV-2 infected cells opens up new therapeutic avenues

A recent study published on the preprint server bioRxiv in October 2020 shows what the protein translation process looks like in specific terms. In doing so, the study has provided new insights that might prove helpful in developing new therapies for COVID-19 patients.

9 Nov 2020

Longer period of morning stiffness reported in children from less affluent families

Children with arthritis affecting five or more joints, called polyarticular juvenile idiopathic arthritis (polyarticular JIA), living in less affluent families were twice as likely to report more than an hour of morning joint stiffness, compared to their counterparts from more affluent families, according to a study by investigators at Hospital for Special Surgery.

9 Nov 2020

Immune-evading variants can emerge in SARS-CoV-2, researchers warn

An international team of researchers has shown that a mutation within severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) – the agent responsible for the coronavirus disease 2019 (COVID-19) – enables the pathogen to evade antibody-mediated immunity while maintaining replication fitness and increasing viral loads.

9 Nov 2020

Researchers to develop new optogenetic tools for biology and medicine

The European Research Council (ERC) is providing 10 million euros in funding for an interdisciplinary, collaborative project in the structural and biophysical analysis of selected photoreceptors and their development into "OptoGPCRs", light-controlled molecular switches with a wide range of applications in biology and medicine.

8 Nov 2020

As faith in vaccines falters, Biden is under pressure to name new FDA chief stat

President-elect Joe Biden made COVID-19 a linchpin of his campaign, criticizing President Donald Trump's leadership on everything from masks and packed campaign rallies to vaccines.

8 Nov 2020

New strategy shows promises for treating RNA-repeat expansion disorders

A new strategy for treating a variety of diseases known as RNA-repeat expansion disorders, which affect millions of people, has shown promise in proof-of-principle tests conducted by scientists at Scripps Research.

8 Nov 2020

Biologic or targeted synthetic DMARDs reduce dementia in patients with rheumatoid arthritis

The incidence of dementia in patients with rheumatoid arthritis is lower in patients receiving biologic or targeted synthetic disease modifying antirheumatic drugs (DMARDs) than in patients who receive conventional synthetic DMARDs, according to a new study.

6 Nov 2020

VA joins Pentagon in recruiting volunteers for COVID vaccine trials

The Department of Veterans Affairs is recruiting 8,000 volunteers for the Phase 3 clinical trials of at least four COVID-19 vaccine candidates at 20 federal medical facilities across the U.S., according to officials with the VA and Operation Warp Speed, the Trump administration's initiative to fast-track a coronavirus vaccine.

6 Nov 2020

Commonly prescribed anti-depressant may halt the growth of childhood sarcoma

A new study has found that a commonly prescribed anti-depressant may halt growth of a type of cancer known as childhood sarcoma, at least in mice and laboratory cell experiments.

6 Nov 2020

How do low levels of oxygen damage the brain?

In this interview, Professor Paul Tesar and Kevin Allan speak to News-Medical about how low levels of oxygen damage the brain.

6 Nov 2020

Researchers develop novel chemo-immunotherapy agent to treat pancreatic tumors

Pancreatic cancer is highly lethal: according to the National Cancer Institute, only about 10 percent of patients remain alive five years after diagnosis.

6 Nov 2020

Research describes novel molecules designed to treat or prevent COVID-19 infection

Neoleukin Therapeutics, Inc., "Neoleukin" (NASDAQ:NLTX), a biopharmaceutical company utilizing sophisticated computational methods to design de novo protein therapeutics, today announced the publication in Science of research describing novel molecules designed to treat or prevent infection by the virus that causes COVID-19, SARS-CoV-2.

6 Nov 2020

Therapeutics News and Research

Immunotherapy drugs trigger inflammatory arthritis in subset of cancer patients

Researchers identify factors that improve diagnosis of chronic nonbacterial osteomyelitis

HSS presents research related to rheumatology and orthopedic surgery at 2020 ACR annual meeting

Researchers discover unique anti-cancer function for previously well-characterized protein

New biomaterial significantly reduces scar formation following wounds

Researchers compare racial variations in unilateral versus bilateral knee replacement surgery

Exosome-mediated mRNA delivery generates broad immune response to multiple SARS-CoV-2 proteins

Aspirin to be tested as a potential COVID-19 treatment as part of RECOVERY trial

Translational study within SARS-CoV-2 infected cells opens up new therapeutic avenues

Longer period of morning stiffness reported in children from less affluent families

Immune-evading variants can emerge in SARS-CoV-2, researchers warn

Researchers to develop new optogenetic tools for biology and medicine

As faith in vaccines falters, Biden is under pressure to name new FDA chief stat

New strategy shows promises for treating RNA-repeat expansion disorders

Biologic or targeted synthetic DMARDs reduce dementia in patients with rheumatoid arthritis

VA joins Pentagon in recruiting volunteers for COVID vaccine trials

Commonly prescribed anti-depressant may halt the growth of childhood sarcoma

How do low levels of oxygen damage the brain?

Researchers develop novel chemo-immunotherapy agent to treat pancreatic tumors

Research describes novel molecules designed to treat or prevent COVID-19 infection

Understanding the DNA Damage Response in Innate Immunity eBook

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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