Major Depressive Disorder News and Research

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Major Depressive Disorder (MDD) is a psychiatric condition characterized by depressed mood or anhedonia (significant loss of interest or pleasure). The condition affects more than 15.7 million adults and approximately 3 million adolescents (aged 13 to 17 years) in the USA each year.

Feeling sad can alter levels of inflammatory proteins linked to increased risk of comorbid diseases

Feeling sad can alter levels of stress-related opioids in the brain and increase levels of inflammatory proteins in the blood that are linked to increased risk of comorbid diseases including heart disease, stroke and metabolic syndrome, according to a study by researchers at The University of Texas Health Science Center at Houston.

17 Dec 2015

Cognitive behavioral therapy can be equally effective as second generation antidepressant for depression

Major depressive disorder affects more than 32 million Americans, and their first stop for treatment is often their primary care provider. A recent evidence review of several alternatives to medication found that using cognitive behavioral therapy as the first treatment for depression can be equally effective as using a second generation antidepressant.

10 Dec 2015

Novel antidepressant appears to be safe, effective against depression in clinical trial

A small clinical trial of a novel antidepressant that stimulates neurogenesis - the production of new brain cells - shows that the compound appears to be safe and may be effective against depression.

9 Dec 2015

New research finds insufficient evidence for use of Omega 3 supplements in treating major depressive disorder

New research out today concludes that there is insufficient evidence for the use of taking an Omega 3 fatty acid supplement in treating major depressive disorder.

5 Nov 2015

Estradiol fluctuation may enhance emotional sensitivity to psychosocial stress during menopausal transition

If you're feeling a little blue during the transition to menopause, there's good reason, according to a new study being reported online today in Menopause, the journal of The North American Menopause Society (NAMS). The study from the Department of Psychiatry at the University of North Carolina at Chapel Hill suggests that the estradiol (a form of estrogen) fluctuation that is common during the menopausal transition may enhance emotional sensitivity to psychosocial stress.

4 Nov 2015

New Rice University study explores connections between fatal bereavement and cardiovascular risk

Medical professionals know that when a spouse dies, the surviving partner is at increased risk of suffering early mortality - but they don't entirely understand why. A new Rice University professor has received a $3.765 million R01 grant from the National Institutes of Health to embark on a five-year study of the connection between psychological and physiological responses to such extraordinary stress.

27 Oct 2015

Neurocrine Biosciences announces positive data from NBI-98854 Phase III trial in tardive dyskinesia

Neurocrine Biosciences, Inc. announced today that NBI-98854, a highly selective small molecule VMAT2 inhibitor, showed a statistically significant reduction in tardive dyskinesia during the six weeks of placebo-controlled treatment in the Kinect 3 clinical trial. This Phase III trial included moderate to severe tardive dyskinesia patients with underlying schizophrenia, schizoaffective disorder, bipolar or major depressive disorder.

8 Oct 2015

FDA approves MagVenture MagVita TMS Therapy system for treatment of Major Depressive Disorder

On July 31, 2015 the US Food and Drug Administration cleared the MagVita TMS Therapy system for the treatment of Major Depressive Disorder in adult patients who have failed to receive satisfactory improvement from prior antidepressant medication in the current episode.

28 Aug 2015

Physicians may now have tools to predict people at greater risk of attempting suicide

People being treated for bipolar disorder and other psychiatric illnesses are at greater risk of attempting suicide, but physicians may now have tools to predict which of those individuals will attempt it and intervene early to prevent such tragedies from occurring.

18 Aug 2015

Neurocrine completes enrollment in Phase III clinical trial of NBI-98854 in tardive dyskinesia patients

Neurocrine Biosciences, Inc. announced today that it has recently completed subject randomization of the Phase III clinical trial (Kinect 3 Study) of its proprietary Vesicular Mono-Amine Transporter 2 (VMAT2) compound NBI-98854 in tardive dyskinesia patients.

13 Aug 2015

Aerobic exercise can help reduce excessive daytime sleepiness among depressed people

Aerobic exercise can help alleviate excessive daytime sleepiness among depressed individuals, researchers with UT Southwestern Medical Center's Center for Depression Research and Clinical Care have found.

12 Aug 2015

FDA accepts sNDA to review Brintellix clinical trial data for treatment of major depressive disorder

Takeda Pharmaceutical Company Limited (Takeda) and H. Lundbeck A/S (Lundbeck) announced today the U.S. Food and Drug Administration (FDA) has accepted a supplemental New Drug Application (sNDA) for review to add clinical data regarding the effect of Brintellix (vortioxetine) on certain aspects of cognitive function in adults with Major Depressive Disorder (MDD) to the current product label.

11 Aug 2015

Current psychotherapy treatments less than optimal for war veterans suffering from PTSD

Our nation's veterans continue to suffer emotional and psychological effects of war—some for decades. And while there has been greater attention directed recently toward post-traumatic stress disorder (PTSD), and more veterans are seeking help, current psychotherapy treatments are less than optimal, according to a new narrative review published in the August 4, 2015 issue of JAMA.

4 Aug 2015

Study reveals potential new therapeutic target for depression treatment

Increasing the levels of a signaling molecule found in the brain can positively alter response to stress, revealing a potential new therapeutic target for treatment of depression, UT Southwestern Medical Center researchers said.

22 Jul 2015

New research shows that pupil response can predict child's risk of depression

How much a child's pupil dilates in response to seeing an emotional image can predict his or her risk of depression over the next two years, according to new research from Binghamton University.

8 Jul 2015

Virtual human helps veterans with PTSD, people with mental illness build job interview skills

Finding a job is difficult for veterans with posttraumatic stress disorder (PTSD) and individuals with severe mental illness, who have high unemployment rates even though many want to work.

1 Jul 2015

Neuralstem's HK532-IGF-1 neural stem cells therapy for Alzheimer's disease presented at ISSCR Annual Meeting

Neuralstem, Inc., a biopharmaceutical company using neural stem cell technology to develop small molecule and cell therapy treatments for central nervous system diseases, announced that the poster "Human Neural Stem Cells Expressing IGF-1: A Novel Cellular Therapy for Alzheimer's Disease" was presented yesterday at the International Society for Stem Cell Research (ISSCR) Annual Meeting in Stockholm, Sweden.

27 Jun 2015

New depression treatment from Magstim to be exhibited at Royal College of Psychiatry International Congress 2015

The Magstim Company Ltd, an innovative and award winning Wales-based medical device manufacturer, will be showing its Magstim Rapid2 Therapy System at the Royal College of Psychiatry International Congress 2015 in Birmingham, UK, 29th June-2nd July.

From Magstim 17 Jun 2015

Recurrent major depression may increase osteoporosis risk in men

A recent study from the University of Eastern Finland in collaboration with Deakin University, Australia, shows that recurrent major depressive disorder (MDD) in men is associated with lower bone density. The use of antidepressants was also associated with lower bone mineral density (BMD), but this association was dependent on the person's weight and site of bone measurement.

12 Jun 2015

People across the world are living longer but spending more time in ill health

People across the world are living longer but spending more time in ill health as rates of nonfatal diseases and injuries - including diabetes and hearing loss - decline more slowly than death rates, according to a new analysis of 301 diseases and injuries in 188 countries.

9 Jun 2015