Neurodegenerative Diseases News and Research

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Spatial aging clocks reveal how T cells and neural stem cells shape brain aging

Researchers developed spatial aging clocks to map brain cell aging, revealing how T cells accelerate aging and NSCs rejuvenate neighboring cells, offering new insights into brain health and interventions.

22 Dec 2024

The crucial role of 'chaperones' in maintaining neuronal function

A team of researchers from the University of Massachusetts Amherst is the first to show how proteins called "chaperones" are vital in ensuring that neurons can transmit signals to one another. When this neurotransmission breaks down, devastating diseases such as Alzheimer's and Parkinson's along with many others, can occur.

20 Dec 2024

Vanderbilt researchers achieve milestone in Alzheimer's drug development

Researchers at the Warren Center for Neuroscience Drug Discovery, a clinical stage biotech within the Vanderbilt University School of Medicine Basic Sciences, have detailed the successful drug discovery of a phase I single ascending dose clinical trial of VU319, a drug for memory loss in people with Alzheimer's disease and schizophrenia.

19 Dec 2024

Chronic gut infection may play role in Alzheimer’s disease progression

Arizona State University and Banner Alzheimer's Institute researchers, along with their collaborators, have discovered a surprising link between a chronic gut infection caused by a common virus and the development of Alzheimer's disease in a subset of people.

19 Dec 2024

Modified lipid nanoparticles for targeted mRNA delivery to the brain

Penn Engineers have modified lipid nanoparticles (LNPs) - the revolutionary technology behind the COVID-19 mRNA vaccines - to not only cross the blood-brain barrier (BBB) but also to target specific types of cells, including neurons.

18 Dec 2024

Nutraceuticals: exploring potential benefits and challenges of an unregulated healthcare frontier

Nutraceuticals offer potential health benefits, from migraine relief to cognitive support, but safety and regulatory issues must be addressed for effective use.

18 Dec 2024

Researchers discover weakness in bacterial machinery that drives antibiotic resistance

Superbugs, bacteria that are immune to multiple antibiotics, pose a great challenge to modern medicine. Researchers from the B CUBE - Center for Molecular Bioengineering at TUD Dresden University of Technology and Institut Pasteur in Paris identified a weakness in the bacterial machinery that drives antibiotic resistance adaptation.

17 Dec 2024

Heat waves pose unique threats to people with Parkinson's and dementia

As 2024 is set to end as Earth's hottest year on record – breaking the previous record set in 2023– a UCLA Health researcher says people living with neurodegenerative diseases will be uniquely vulnerable to worsening heat waves because of a higher risk of heat-related complications.

17 Dec 2024

Promising ultrasound therapy for Alzheimer's disease licensed to new start-up

A promising ultrasound therapy to potentially restore brain function in people with Alzheimer's disease has been licenced to a new start-up spun out of The University of Queensland.

16 Dec 2024

TTUHSC researcher to uncover mechanisms that regulate gene expression in Alzheimer's disease

More than six million Americans are affected by Alzheimer's disease, a form of dementia marked by accumulation of amyloid-β within the brain. Amyloid-β is a relatively small protein that forms toxic plaques in the brain contributing to the harmful effects of Alzheimer's disease.

14 Dec 2024

New funding for innovative dementia vaccine research

Alzheimer's disease and frontotemporal dementia are devastating disorders that emerge following the buildup of misfolded proteins in the brain.

13 Dec 2024

Portable MRI and AI improve Alzheimer’s diagnosis with cost-effective precision

Researchers optimized portable low-field MRI with machine learning to improve brain morphometry and white matter hyperintensity detection, making Alzheimer's diagnosis more accessible and cost-effective.

12 Dec 2024

Key plasma proteins signal critical periods in brain aging

Researchers identified 13 plasma proteins linked to brain aging, uncovering dynamic patterns and biomarkers for early intervention in aging-related brain health.

10 Dec 2024

Scripps Research develops brain-inspired AI for real-time video analysis

Imagine an artificial intelligence (AI) model that can watch and understand moving images with the subtlety of a human brain.

9 Dec 2024

Researchers unveil groundbreaking approach to understanding brain activity

A new way of mapping activity and connections between different regions of the brain has revealed fresh insights into how higher order functions like language, thought and attention, are organized.

9 Dec 2024

New insights into the mechanisms of "Niemann-Pick type C" in children

In the journal "Science Translational Medicine", scientists from DZNE and LMU Hospital report on new insights into the mechanisms of "Niemann-Pick type C" (NPC), a rare neurodegenerative disease associated with dementia that can manifest as early as childhood.

6 Dec 2024

Ketone body β-hydroxybutyrate restores protein balance and targets Alzheimer’s-linked aggregates

Scientists identify β-hydroxybutyrate as a key regulator of protein solubility, offering a novel pathway to combat neurodegeneration in aging and Alzheimer’s disease.

4 Dec 2024

Glyphosate exposure linked to lasting brain inflammation

The human brain is an incredibly adaptable organ, often able to heal itself even from significant trauma.

4 Dec 2024

Scientists identify molecular mechanism behind idiopathic autism

Autism is a neurodevelopmental disorder characterized by difficulties in communication and social behavior. Approximately 20% of cases are linked to a specific genetic mutation, but the origin of the remaining 80%, known as idiopathic autism, remains a mystery.

4 Dec 2024

Behavioral chaos in Alzheimer’s disease mice decoded by machine learning

Researchers use machine learning to identify behavioral disruptions in Alzheimer’s disease mouse models, highlighting a potential therapeutic target in fibrinogen-microglia interactions.

3 Dec 2024