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DNA, or deoxyribonucleic acid, is the hereditary material in humans and almost all other organisms. Nearly every cell in a person’s body has the same DNA. Most DNA is located in the cell nucleus (where it is called nuclear DNA), but a small amount of DNA can also be found in the mitochondria (where it is called mitochondrial DNA or mtDNA).

Biodegradable, non-ionic polymeric nanovesicles efficiently encapsulate and deliver siRNA

Small interfering RNAs, or siRNAs, hold promise to treat tumors, through their ability to specifically knock down oncogenes that promote tumor growth, without the toxicity that accompanies chemotherapy. However, the siRNAs need a delivery vehicle to protect them from degradation and clearance on their journey through the bloodstream to the cancer tumor.

25 May 2022

Computational modeling fine tunes RBD-1C aptamer against SARS-CoV-2 S protein

Researchers used the SARS-CoV-2 sequence against aptamers to perform the in silico selection of an aptamer against the SARS-CoV-2 S protein.

24 May 2022

Research provides insight into genetic mechanisms of Wilms tumor

New research from Ann & Robert H. Lurie Children's Hospital of Chicago and collaborators from other institutions provides insights into some of the genetic characteristics resulting in the development of relapse in patients with Wilms tumor (nephroblastoma), the most common type of pediatric cancer of the kidney.

24 May 2022

Researchers discover osteogenetic oligodeoxynucleotide that promotes bone differentiation

Bone tissue homeostasis is maintained by a balance between bone formation by osteoblasts and bone resorption by osteoclasts.

23 May 2022

Synthetic biologists interrogate single-celled survivalists to understand stress response

Rice University synthetic biologists and bioengineers are preparing to interrogate some single-celled survivalists to find out how they deal with stress.

23 May 2022

Novel genetic test enables earlier, more accurate diagnosis of primary immunodeficiency disorders

Primary immunodeficiency disorders (PID) can result in chronic and sometimes life-threatening infections. More than 450 PIDs have been described, but timely and accurate diagnoses remain a challenge.

23 May 2022

First draft genome sequence of the Monkeypox virus associated with major outbreak

In a recent study posted to the Virological discussion forum, researchers revealed a draft genome sequence of the monkeypox virus associated with a recent outbreak in Portugal.

23 May 2022

Repurposed drug clofoctol blocks SARS-CoV-2 replication in mouse study

A new paper presents the results of a mouse study using the repurposed antibacterial drug clofoctol against this virus.

23 May 2022

Deep visual proteomics is redefining cancer diagnostics

In a recent study published in the journal Nature Biotechnology, researchers introduced deep visual proteomics (DVP), an amalgamation of artificial intelligence (AI) for image analysis and mass spectrometry (MS) for proteomic profiling of biological samples.

22 May 2022

Scientists discover how immune proteins defend plants against invading microorganisms

Scientists from the Max Planck Institute for Plant Breeding Research and the University of Cologne, Germany, have discovered a novel biochemical mechanism explaining how immune proteins defend plants against invading microorganisms.

20 May 2022

Research provides new insight into how Crimean-Congo hemorrhagic fever virus causes disease

Army scientists determined that the body's own natural immune response contributes to disease severity in mice infected with Crimean-Congo hemorrhagic fever virus (CCHFV), which causes a widespread tick-borne viral infection in humans.

20 May 2022

Researchers discover how one type of T cell creates functionally distinct, but genetically identical daughter cells

Scientists at St. Jude Children's Research Hospital have solved an immunology puzzle. A CD8+ T cell can have two functionally distinct daughter cells after it divides, despite the cells being genetically identical.

20 May 2022

Blood-based biomarker can predict the benefit of immunotherapy to lung cancer patients

A blood-based tumor biomarker can predict the benefit of immunotherapy to patients with non-small cell lung cancer, according to a study published in Nature Medicine.

20 May 2022

Epistatic drift leads to unpredictability in protein evolution

A critical goal in genetics and evolution is predicting the effects of mutations that may happen in the future and inferring the effects of those that happened in the past.

19 May 2022

‘Sting’ protein’s response to clean up damaged brain cells may accelerate Parkinson’s disease progression

In studies with mouse and human tissue, as well as live mice, Johns Hopkins Medicine researchers report that a snag in the normal process of cleaning up broken DNA in brain cells may hasten the progression of Parkinson's disease.

19 May 2022

Downregulation of MHC-I surface expression by SARS-CoV-2 accessory proteins

Researchers analyze the mechanisms by which two SARS-CoV-2 accessory proteins, ORF3a and ORF7a, can downregulate the expression of MHC-I.

19 May 2022

Researchers discover potential treatment approach for advanced uveal melanoma

An international team of researchers led by University College Dublin (UCD) have uncovered a potential treatment approach for advanced uveal melanoma (UM), a type of cancer that effects the eye.

19 May 2022

Intestinal microbiome may contribute to the pathogenesis of MSI colon cancers, study suggests

Investigators from Rutgers Cancer Institute of New Jersey, New Jersey's only National Cancer Institute- Designated Comprehensive Cancer Center, led a collaborative study to examine the patterns of druggable oncogenic fusions in colon cancer specimens including microsatellite-stable and unstable (MSI) tumors.

19 May 2022

Potential therapeutic target discovered for pancreatic ductal adenocarcinoma tumors

Northwestern Medicine investigators have discovered a potential therapeutic target for the most common type of pancreatic cancer, according to a study published in Developmental Cell.

19 May 2022

The prevalence of rodent-borne zoonotic viruses in Europe among the small mammals inhabiting farming landscapes

In northwest Spain, scientists screened 526 wild small mammals for zoonotic viruses and identified several viruses, such as hantavirus, orthopoxvirus, and arenavirus.

19 May 2022

DNA News and Research

Further Reading

Biodegradable, non-ionic polymeric nanovesicles efficiently encapsulate and deliver siRNA

Computational modeling fine tunes RBD-1C aptamer against SARS-CoV-2 S protein

Research provides insight into genetic mechanisms of Wilms tumor

Researchers discover osteogenetic oligodeoxynucleotide that promotes bone differentiation

Synthetic biologists interrogate single-celled survivalists to understand stress response

Novel genetic test enables earlier, more accurate diagnosis of primary immunodeficiency disorders

First draft genome sequence of the Monkeypox virus associated with major outbreak

Repurposed drug clofoctol blocks SARS-CoV-2 replication in mouse study

Deep visual proteomics is redefining cancer diagnostics

Scientists discover how immune proteins defend plants against invading microorganisms

Research provides new insight into how Crimean-Congo hemorrhagic fever virus causes disease

Researchers discover how one type of T cell creates functionally distinct, but genetically identical daughter cells

Blood-based biomarker can predict the benefit of immunotherapy to lung cancer patients

Epistatic drift leads to unpredictability in protein evolution

‘Sting’ protein’s response to clean up damaged brain cells may accelerate Parkinson’s disease progression

Downregulation of MHC-I surface expression by SARS-CoV-2 accessory proteins

Researchers discover potential treatment approach for advanced uveal melanoma

Intestinal microbiome may contribute to the pathogenesis of MSI colon cancers, study suggests

Potential therapeutic target discovered for pancreatic ductal adenocarcinoma tumors

The prevalence of rodent-borne zoonotic viruses in Europe among the small mammals inhabiting farming landscapes

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