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Maternal cell phone use associated with decrease in infants' speech development

Research suggests that phone use may have an effect on children's speech input and language development.

26 Jun 2024

Nonhuman primate model reveals early-stage Alzheimer’s disease progression

Research in nonhuman primates is opening the possibility of testing treatments for the early stages of Alzheimer’s and similar diseases, before extensive brain cell death and dementia set in.

26 Jun 2024

“G900” gene enhancers may play a pivotal role in asthma-associated inflammation

Type-2 helper T (Th2) cells play intricate roles in the inflammatory response underlying asthma. Elevated levels of the protein GATA3 stimulate the maturation of these cells. Consequently, gene regions known as enhancers, which enhance the expression of the GATA3 gene, have been implicated in asthma-associated inflammation.

26 Jun 2024

Study provides resource for investigating diabetes-linked transcription factors

Scientists have generated a comprehensive map of the gene targets regulated by the transcription factors HNF4A and HNF1A in human pancreatic beta cells and liver cells. Published in the journal Nature Communications, the study revealed common and tissue-specific molecular pathways regulated by HNF4A and HNF1A, two proteins that possess important functions governing the development and function of the pancreas and liver.

26 Jun 2024

Breakthrough biomarker predicts recurrence risk in clear cell renal cancer

Researchers from the University of Michigan Health Rogel Cancer Center have discovered a biomarker that could help identify which renal cancer patients have a higher risk of recurrence.

25 Jun 2024

Study reveals brain health benefits of intermittent fasting and healthy diet plans

Researchers from Johns Hopkins Medicine and the National Institutes of Health's National Institute on Aging say their study of 40 older adults with obesity and insulin resistance who were randomly assigned to either an intermittent fasting diet or a standard healthy diet approved by the U.S. Department of Agriculture (USDA) offers important clues about the potential benefits of both eating plans on brain health.

25 Jun 2024

New curative treatment for sickle cell disease shows promising results in international trial

Vanderbilt University Medical Center (VUMC) researchers are touting data from a multicenter, international phase 2 clinical trial showing a new, curative treatment for sickle cell disease (SCD).

25 Jun 2024

Combining CYFRA 21-1 with CXCR1 and cxcr2 levels for predicting recurrence in stage III squamous cell lung carcinoma

Despite efforts, tumor recurrence is diagnosed in 35–40% of patients with stage III squamous cell lung carcinoma (SCLC) during the first year after treatment.

25 Jun 2024

Senecavirus A could be a promising new therapeutic approach for hepatocellular carcinoma

Hepatocellular carcinoma (HCC) is a highly aggressive tumor with limited treatment options and high mortality.

25 Jun 2024

New light-based detection method improves screening for food contaminants

Every so often, a food product is recalled because of some sort of contamination. For consumers of such products, a recall can trigger doubt in the safety and reliability of what they eat and drink.

25 Jun 2024

New MDMA variants could be promising alternatives for safe psychotherapeutic applications

The use of the active ingredient 3,4-methylenedioxy-N-methylamphetamine (MDMA), commonly known as "ecstasy", to support psychotherapy for mental illnesses such as post-traumatic stress disorder is being discussed worldwide.

25 Jun 2024

Genetic variation in people of African ancestry linked to increased risk of diabetes complications

A genetic variation common in people of African ancestry is associated with an increased risk of complications from diabetes, including diabetic retinopathy, according to a report published June 25 in the journal Nature Medicine.

25 Jun 2024

Novel genetic predisposition to being overweight or obese identified

Researchers performed a case-control study to compare metabolic changes between individuals homozygous for a loss-of-function genetic variation in small integral membrane protein 1 (SMIM1) and the general population.

25 Jun 2024

Open-source platform enables high-definition spatial transcriptomics

An open-source platform developed by researchers in Nikolaus Rajewsky's lab at the Max Delbrück Center creates molecular maps from patient tissue samples with subcellular precision, enabling detailed study and potentially enhancing routine clinical pathology. The study was published in "Cell."

25 Jun 2024

MicroRNAs shed light on aggressive youthful type 2 diabetes

Type 2 diabetes in young people ages 10 to19 has more than doubled in the past 20 years, yet it remains difficult for physicians to predict who will be diagnosed and who will improve with treatment. A newly published study from the University of Oklahoma shows that measuring the circulating abundance of microRNAs – which affect insulin-producing beta cells in the pancreas – is likely as effective as measuring the level of sugar in the blood for determining how a young person with the condition will fare.

25 Jun 2024

Beyond genes, new research explores mechanics and calcium signaling

Using animals to study heart disease doesn't always translate well to human health outcomes, and human heart cells available for research don't work outside the human body.

25 Jun 2024

Multi-regional sampling uncovers hidden complexity in liver cancer

A study led by clinician-scientists and scientists from the National Cancer Centre Singapore (NCCS) and A*STAR's Genome Institute of Singapore (GIS) and funded by the National Research Foundation Singapore (NRF) has discovered unexpected molecular heterogeneity even within the same liver tumors. More than 40% of HCC harbors more than one molecular subtype within the same tumor and in these, the clinical outcomes for the patients are best predicted by the most aggressive subtype.

25 Jun 2024

New enzyme targets hold promise for cancer therapies

Researchers at Baylor College of Medicine and collaborating institutions have uncovered new potential therapeutic targets for cancer and new insights into existing cancer drug targets, expanding the breadth of possibilities for treating this disease. Using a comprehensive approach that included integrating proteomics, genomics and epigenomics data from 10 cancer types, the team identified protein and small protein or peptide targets in cancer tissues and validated many of them experimentally as promising candidates for therapeutic strategies. The study appeared in Cell.

25 Jun 2024

Study links gene regulation to allergic airway inflammation

Asthma patients experience respiratory distress due to allergens like house dust mites or pollen. However, the various triggers for asthma share a common pathway involving the release of proteins called type-2 cytokines by Type-2 helper T (Th2) cells and group-2 innate lymphoid cells (ILC2s). Both Th2 and ILC2 require high amounts of GATA-binding protein 3 (GATA3) for their maturation.

25 Jun 2024

WEHI study reveals new methods in detecting necroptosis

Fully automated diagnostic techniques, including liquid handling robots, are poised to improve the lives of millions of people living with inflammatory diseases worldwide.

24 Jun 2024