Therapeutics News and Research

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Researchers explore molecular factors that drive the severity of COVID-19

While most COVID-19 cases are asymptomatic or mild, severe complications associated with acute respiratory distress have led to more than one million deaths worldwide in just several months.

13 Oct 2020

Dynamic map reveals how cells fight microbes and preserve memory for future infections

Researchers have charted the activity of tens of thousands of genes in mouse immune cells over the course of an infection.

12 Oct 2020

Researchers examine the cooperative effects of genes in suppressing neuroendocrine tumors in mice

Volume 11, Issue 28 of Oncotarget features "Genetic analysis of the cooperative tumorigenic effects of targeted deletions of tumor suppressors Rb1, Trp53, Men1, and Pten in neuroendocrine tumors in mice" by Xu et, al. which reported that the authors examined whether the TSGs Rb1, Trp53, Pten, and Men1 have cooperative effects in suppressing neuroendocrine tumors in mice.

12 Oct 2020

Pathways contributing to hypercoagulability in severe SARS‐CoV‐2 patients

In a study by researchers explored the possible mechanisms of the clotting disorder, focusing on the role of hypoxia-related activation of coagulation factors; cytokine storm, activation of neutrophils, and the release of neutrophil extracellular traps.

11 Oct 2020

Penn receives $4.5 million NIH grant to create a comprehensive resource for women’s health

Junhyong Kim, PhD, Chair and Patricia M. Williams Professor of Biology in the School of Arts and Sciences, and Kate O'Neill, MD MTR, Assistant Professor, Department of Obstetrics and Gynecology in the Perelman School of Medicine, have been awarded a Human BioMolecular Atlas Program (HuBMAP) grant supported by the Eunice Kennedy Shriver National Institute of Child Health & Human Development and the Common Fund of the National Institutes of Health.

9 Oct 2020

NIH provides $9.3 million grant to create new Center for Precision Animal Modeling at UAB

A new Center for Precision Animal Modeling, or C-PAM, has been created at the University of Alabama at Birmingham, supported by a five-year, $9.3 million grant from the National Institutes of Health's Office of Research Infrastructure Programs.

9 Oct 2020

Researchers receive €2.35 million to examine disease pathways of viruses

Two University College Dublin (UCD) researchers and SiriusXT, a UCD spin-out company, have been awarded a total of €2.35 million in funding for a disruptive photonics technology project, through Horizon 2020, the EU's research and innovation programme, to examine the disease pathways of viruses.

9 Oct 2020

Researchers develop mitochondrial-targeted prodrug for treating glioblastoma

Houston Methodist researchers found that mice harboring human glioblastoma tumors in their brains had greatly enhanced survival and weight gain when given a newly developed prodrug.

9 Oct 2020

The Native Antigen Company introduces ten new SARS-CoV-2 specific antibodies

The Native Antigen Company, one of the world’s leading suppliers of reagents that enables research into vaccines and diagnostics for emerging and endemic infectious diseases, today announced the introduction of ten new monoclonal antibodies recognizing SARS-CoV-2, the causative agent of COVID-19.

8 Oct 2020

Multi-center Phase I study of anti-VISTA opens for patient enrollment

Dartmouth and Dartmouth-Hitchcock Norris Cotton Cancer Center will serve as one of the lead institutions for a new multi-center clinical trial of anti-VISTA, now open and recruiting for patient enrollment.

7 Oct 2020

UC Davis School of Medicine and UTHealth receive NIH grant for dementia research

A team of brain scientists from UC Davis School of Medicine and The University of Texas Health Science Center at Houston has been awarded a six-year grant expected to total $53.6 million from the National Institutes of Health.

7 Oct 2020

Sofosbuvir combined with other antivirals is more effective against COVID-19, shows study

Columbia Engineering researchers report that Sofosbuvir-terminated RNA is more resistant to the proofreader of SARS-CoV-2, the virus that causes COVID-19, than Remdesivir-terminated RNA.

7 Oct 2020

Two Penn Medicine researchers selected for prestigious NIH Director's Awards

Picture a future where embedded medical devices not only treat and teach patients, but learn from them. Imagine chronic pain being managed without the negative side effects of opioids. Penn Medicine researchers are working to make those scenarios a reality.

6 Oct 2020

Salk physician-scientist has been named an NIH Director's New Innovator for 2020

Salk Institute Assistant Professor Edward Stites has been named an NIH Director's New Innovator for 2020 as part of the National Institutes of Health's High-Risk, High-Reward Research Program.

6 Oct 2020

UM associate professor wins multiple awards for ear, skin science

University of Montana scientist Monica Serban is on a research roll. In recent months the UM associate professor and her team have earned three awards totaling $3.9 million in funding to study preventing hearing loss among U.S. troops, combating ear infections and creating a synthetic skin product.

6 Oct 2020

Researchers discover a new, rapid method to fabricate nanoparticles

Northwestern University researchers are casting a net for nanoparticles.The team has discovered a new, rapid method for fabricating nanoparticles from a simple, self-assembling polymer.

6 Oct 2020

First biobank in Australia for chromosome 15 disorders

The first biobank in Australia aiming to improve research and treatments into rare genetic diseases caused by changes to genes on chromosome 15, including Prader-Willi Syndrome and Angelman Syndrome, will be established at the Murdoch Children's Research Institute.

5 Oct 2020

Supporting Coronavirus Research with Liquid Chromatography

The RNA in viruses such as SARS-CoV-2 are an ideal research target. RNA purification with liquid chromatography is essential in the fight against SARS-CoV-2.

From KNAUER Wissenschaftliche Geräte GmbH 5 Oct 2020

Furin cleavage site of SARS-CoV-2 spike glycoprotein enhances viral replication in the lungs

In a new bioRxiv* preprint paper, researchers from the Imperial College London, King's College London, and the University of Bristol in the United Kingdom show that the furin cleavage site of SARS-CoV-2 spike glycoprotein represents a key determinant for transmission among humans, as it substantially facilitates replication in airway cells - opening the door for the development of novel therapeutics.

4 Oct 2020

Anti-sense agents suppress SARS-CoV-2 virus

Researchers in the United States have conducted a study showing that anti-sense agents called peptide-conjugated morpholino oligomers (PPMOs) have the ability to specifically and potently suppress the growth of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) – the agent responsible for the current coronavirus disease 2019 (COVID-19) pandemic.

4 Oct 2020

Therapeutics News and Research

Researchers explore molecular factors that drive the severity of COVID-19

Dynamic map reveals how cells fight microbes and preserve memory for future infections

Researchers examine the cooperative effects of genes in suppressing neuroendocrine tumors in mice

Pathways contributing to hypercoagulability in severe SARS‐CoV‐2 patients

Penn receives $4.5 million NIH grant to create a comprehensive resource for women’s health

NIH provides $9.3 million grant to create new Center for Precision Animal Modeling at UAB

Researchers receive €2.35 million to examine disease pathways of viruses

Researchers develop mitochondrial-targeted prodrug for treating glioblastoma

The Native Antigen Company introduces ten new SARS-CoV-2 specific antibodies

Multi-center Phase I study of anti-VISTA opens for patient enrollment

UC Davis School of Medicine and UTHealth receive NIH grant for dementia research

Sofosbuvir combined with other antivirals is more effective against COVID-19, shows study

Two Penn Medicine researchers selected for prestigious NIH Director's Awards

Salk physician-scientist has been named an NIH Director's New Innovator for 2020

UM associate professor wins multiple awards for ear, skin science

Researchers discover a new, rapid method to fabricate nanoparticles

First biobank in Australia for chromosome 15 disorders

Supporting Coronavirus Research with Liquid Chromatography

Furin cleavage site of SARS-CoV-2 spike glycoprotein enhances viral replication in the lungs

Anti-sense agents suppress SARS-CoV-2 virus

Industry Focus eBook - Microbiome (1st edition) eBook

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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