Therapeutics News and Research

RSS

Nanotechnological drug delivery system enhances the effectiveness of melanoma treatment

Researchers at Tel Aviv University, led by Prof. Ronit Satchi-Fainaro of TAU's Department of Physiology and Pharmacology at the Sackler School of Medicine, have developed an innovative nanotechnological drug delivery system that significantly enhances the effectiveness of treatment for the aggressive skin cancer melanoma.

8 Sep 2020

Microglia-targeting nanotherapeutics for treatment of neurodegenerative disorders

Inspired by the need for new and better therapies for neurodegenerative diseases, such as Parkinson's disease and Alzheimer's disease, Rutgers University researchers are exploring the link between uncontrolled inflammation within the brain and the brain's immune cells, known as microglia.

8 Sep 2020

International registries show an increase in PCI procedures in Japan, U.S.

Japan and the U.S. have seen an increase in percutaneous coronary intervention (PCI) procedures, which is driven primarily by a rise in elective PCIs in Japan compared to non-elective in the U.S., according to a study in the Journal of the American College of Cardiology.

7 Sep 2020

PI3K/mTOR and topoisomerase inhibitors suggested as candidates to reduce expression of ACE2

A recent study published in the preprint server medRxiv in September 2020 shows that the already approved drug families called P13K/mTOR and topoisomerase inhibitors may be useful in reducing individual susceptibility to the virus.

7 Sep 2020

Novel RNA vaccine from Arcturus Therapeutics protects mice against SARS-CoV-2

A new study published on the preprint server bioRxiv in September 2020 reports a novel RNA vaccine platform that shows robust protection against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in mice and performs much better than a conventional mRNA vaccine. This could allow single-dose immunization, allowing progress towards global vaccination.

6 Sep 2020

Early-phase Russian trials reveal safety and immunogenicity of two formulations of a two-part vaccine

Results from two early-phase Russian non-randomised vaccine trials (Sputnik V) in a total of 76 people are published today in The Lancet, finding that two formulations of a two-part vaccine have a good safety profile with no serious adverse events detected over 42 days, and induce antibody responses in all participants within 21 days.

5 Sep 2020

Researchers develop novel model to study factors that cause type 2 diabetes

Using cells taken from patients with type 2 diabetes and new techniques to convert them into specialized precursors of muscle cells, researchers have developed a novel 'disease-in-a-dish' model to study the basic molecular factors that lead to the development of type 2 diabetes.

4 Sep 2020

CRISPR-based system suppresses genes related to AAV antibody production

Gene therapy generally relies on viruses, such as adeno-associated virus (AAV), to deliver genes into a cell. In the case of CRISPR-based gene therapies, molecular scissors can then snip out a defective gene, add in a missing sequence or enact a temporary change in its expression, but the body's immune response to AAV can thwart the whole endeavor.

4 Sep 2020

Researchers develop unique method to coax bone marrow stem cells into specialized cells

Researchers at the University of Illinois Chicago have developed a unique method for precisely controlling the deposition of hydrogel, which is made of water-soluble polymers commonly used to support cells in experiments or for therapeutic purposes.

4 Sep 2020

Simulation platform teaches students the fundamentals of responses to pandemics

In 2015, a team of specialists in modeling disease outbreaks got together with educators to create Operation Outbreak, an educational platform and simulation intended to teach high school and college students the fundamentals of responses to pandemics.

3 Sep 2020

COVID-19 vaccine candidate protects animals against SARS-CoV-2

Most people with COVID-19 have relatively mild disease, but a subset of people develop severe pneumonia and respiratory failure, potentially leading to death.

3 Sep 2020

New technology predicts allosteric sites in proteins

A new technology that uses a protein's structure to predict the inner wiring that controls the protein's function and dynamics is now available for scientists to utilize. The tool, developed by researchers at Penn State, may be useful for protein engineering and drug design.

3 Sep 2020

Relation Therapeutics announces Project RE to identify COVID-19 therapeutic candidates

Relation Therapeutics, a drug development company driven by data science and machine learning, today announces Project RE, which will apply Relation Therapeutics’ and its partners’ technology to the identification of repurposed drug combinations as potential therapeutic candidates for COVID-19.

3 Sep 2020

Advanced digital platform aims to improve outcomes for people with Angelman syndrome

An advanced open-source digital platform developed by QUT researchers is being used to build a patient registry aimed at improving outcomes and health service provision for children and adults around the world living with the rare disease Angelman syndrome.

3 Sep 2020

Reformulated generic drug could offer a cost-effective way to accelerate recovery, prevent hospitalizations

Reformulated and patented version of well-known generic drug could prove to be a quick, safe and cost-effective way to accelerate recovery and prevent hospitalizations.

3 Sep 2020

AAV gene therapy often leads to dorsal root ganglion pathology, show studies

A meta-analysis of non-human primate (NHP) studies showed that adeno-associated virus (AAV) gene therapy often caused dorsal root ganglion (DRG) pathology.

3 Sep 2020

Bioengineering technique that boosts protein production could lead to effective COVID-19 vaccine

A bioengineering technique to boost production of specific proteins could be the basis of an effective vaccine against the novel coronavirus that causes COVID-19, new research suggests.

3 Sep 2020

VUMC launches clinical trial of promising COVID-19 treatments in outpatient setting

Vanderbilt University Medical Center is launching a clinical trial of promising treatments for COVID-19 in the outpatient setting.

2 Sep 2020

HSS physicians offer practical advice for educators and surgical trainees on reaching peak performance

Studies show that athletes and musicians achieve peak performance not only by constant practice but also by setting specific goals, engaging with strong mentors and cultivating the attributes of perseverance, stoicism and grit.

1 Sep 2020

Researchers propose new reforms to improve transparency of drug authorizations

On March 28, the Food and Drug Administration (FDA) exercised its Emergency Use Authorization (EUA) authority to allow the use of hydroxychloroquine for the treatment of COVID-19. On June 15, after a number of studies failed to find positive effects, the agency revoked this authorization.

1 Sep 2020

Therapeutics News and Research

Nanotechnological drug delivery system enhances the effectiveness of melanoma treatment

Microglia-targeting nanotherapeutics for treatment of neurodegenerative disorders

International registries show an increase in PCI procedures in Japan, U.S.

PI3K/mTOR and topoisomerase inhibitors suggested as candidates to reduce expression of ACE2

Novel RNA vaccine from Arcturus Therapeutics protects mice against SARS-CoV-2

Early-phase Russian trials reveal safety and immunogenicity of two formulations of a two-part vaccine

Researchers develop novel model to study factors that cause type 2 diabetes

CRISPR-based system suppresses genes related to AAV antibody production

Researchers develop unique method to coax bone marrow stem cells into specialized cells

Simulation platform teaches students the fundamentals of responses to pandemics

COVID-19 vaccine candidate protects animals against SARS-CoV-2

New technology predicts allosteric sites in proteins

Relation Therapeutics announces Project RE to identify COVID-19 therapeutic candidates

Advanced digital platform aims to improve outcomes for people with Angelman syndrome

Reformulated generic drug could offer a cost-effective way to accelerate recovery, prevent hospitalizations

AAV gene therapy often leads to dorsal root ganglion pathology, show studies

Bioengineering technique that boosts protein production could lead to effective COVID-19 vaccine

VUMC launches clinical trial of promising COVID-19 treatments in outpatient setting

HSS physicians offer practical advice for educators and surgical trainees on reaching peak performance

Researchers propose new reforms to improve transparency of drug authorizations

Next-generation therapeutics eBook eBook

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

Latest News