Nucleic Acid News and Research

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An assay capable of detecting SARS-CoV-2 antibodies in breast milk and other samples

In a recent study by US researchers (currently available on the medRxiv* preprint server), a specific immunoassay based on the spike glycoprotein’s receptor-binding domain (RBD) of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is not only well suited for the detection of antibody response after infection and vaccination but may also represent a method of choice when conducting seroepidemiological studies.

19 Jul 2021

Evaluation of a synthetic DNA SARS-CoV-2 vaccine INO-4800 using a nonhuman primate model

A new study published in Vaccine assesses the safety and efficacy of the synthetic DNA vaccine candidate INO-4800, delivered as a single or double dose regime.

18 Jul 2021

Rapid COVID-19 antibody detection with time‐resolved fluorescence immunoassay

A new study published in the journal Biotechnology and Applied Biochemistry deals with the development of a time-resolved fluorescence immunoassay (TRFIA) for the detection of total COVID-19 antibodies in humans.

15 Jul 2021

Scientists identify existing drugs that may inhibit SARS-CoV-2 virus

The COVID-19 pandemic has caused more than 600,000 deaths in the United States since the start of 2020 and more than 4 million globally.

13 Jul 2021

Antigen testing identifies PCR-positive children with live SARS-CoV-2

A recent study finds that antigen-based testing can reliably identify children who are infectious for SARS-CoV-2.

11 Jul 2021

How SARS-CoV-2 has evolved over the course of the pandemic

In an effort to understand the ongoing evolution of the SARS-CoV-2 genome, researchers constructed a phylogenetic tree of all available SARS-CoV-2 genomes.

7 Jul 2021

Developing a face mask that can detect COVID-19

A face mask has been developed that can detect COVID-19. News-Medical spoke to the researchers behind this idea to find out more about how it works.

6 Jul 2021

Improving Yield and Quality of SARS-CoV-2 Isolated Nucleic Acid

Porvair Sciences has further expanded its range of high-performance microplate products for SARS-CoV-2 nucleic acid purification.

From Porvair Sciences Limited 30 Jun 2021

Study shows SARS-CoV-2 breakthrough infections fewer among fully vaccinated

A team of researchers at Indiana University reports genomic evidence of breakthrough infections in fully vaccinated individuals. The study, posted to the pre-print server medRxiv*, suggests that fully vaccinated individuals, including those with asymptomatic infections, are less likely to serve as a source of infection for others.

30 Jun 2021

New components for oligonucleotide drugs show safety, efficacy in treating spinal muscular atrophy

Skoltech researchers and their colleagues from Russia and the UK investigated the safety and efficacy of new chemistry in antisense oligonucleotides used to treat spinal muscular atrophy (SMA), a debilitating genetic disease.

29 Jun 2021

The technology behind face masks that can diagnose COVID-19

Researchers have recently incorporated technology into standard face masks to detect the presence of SARS-CoV-2.

29 Jun 2021

SARS-CoV-2 test in 20 minutes with FISH

A collaboration from the University of Oxford and the University of Warwick has led to research into a novel method of viral detection through rapid fluorescence in situ hybridization (FISH) in order to effectively detect the SARS-CoV-2 virus within 20 minutes.

29 Jun 2021

GenScript and Duke-NUS announce notice of allowance for “Surrogate Virus Neutralization Technology”

GenScript Biotech Corporation ("GenScript", Stock Code: 1548.HK), a world-leading life sciences research and application service and product provider, and Duke-NUS Medical School, a premier, research intensive medical school, announced today that the U.S. Patent and Trade Office has issued a notice of allowance for the patent application for a novel Surrogate Virus Neutralization Technology (sVNT).

23 Jun 2021

A new strategy to combat pathogenic bacterium

Pseudomonas aeruginosa is an opportunistic pathogenic bacterium present in many ecological niches, such as plant roots, stagnant water or even the pipes of our homes. Naturally very versatile, it can cause acute and chronic infections that are potentially fatal for people with weakened immune systems.

21 Jun 2021

Scientists develop low-cost lab-on-paper device for rapid and accurate detection of SARS-CoV-2

A team of scientists from the University of Connecticut, USA, has developed a low-cost lab-on-paper technology to rapidly and easily detect severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. The work has recently been published in a Royal Society of Chemistry’s Lab on a Chip journal.

18 Jun 2021

First insights into human prion disease could help tackle neurodegenerative diseases

Surface features of human prions have been identified for the first time, which may provide key information into treatments of neurodegenerative diseases.

18 Jun 2021

Study finds new clues to explain how Alzheimer’s disease spreads in the brain

Case Western Reserve University researchers studying prions - misfolded proteins that cause lethal incurable diseases - have identified for the first time surface features of human prions responsible for their replication in the brain.

18 Jun 2021

MicroRNAs in urine could be a promising biomarker to diagnose brain tumors, study reveals

A recent study by Nagoya University researchers revealed that microRNAs in urine could be a promising biomarker to diagnose brain tumors.

17 Jun 2021

A comprehensive review on diagnostics of COVID-19

Clinical research on COVID-19 has boomed in the 18 months since the disease first appeared. Countless papers have looked at the topic from almost every possible angle, including methods of detection.

16 Jun 2021

Scientists reveal the mechanism of liquid-liquid phase separation of SARS-CoV-2 nucleocapsid

A team of scientists from the United States has recently revealed how interactions between the SARS-CoV-2 nucleocapsid protein and the double-stranded RNA motifs impart distinct droplet properties that can support multiple viral functions. The study is currently available on the bioRxiv* preprint server.

16 Jun 2021

Nucleic Acid News and Research

An assay capable of detecting SARS-CoV-2 antibodies in breast milk and other samples

Evaluation of a synthetic DNA SARS-CoV-2 vaccine INO-4800 using a nonhuman primate model

Rapid COVID-19 antibody detection with time‐resolved fluorescence immunoassay

Scientists identify existing drugs that may inhibit SARS-CoV-2 virus

Antigen testing identifies PCR-positive children with live SARS-CoV-2

How SARS-CoV-2 has evolved over the course of the pandemic

Developing a face mask that can detect COVID-19

Improving Yield and Quality of SARS-CoV-2 Isolated Nucleic Acid

Study shows SARS-CoV-2 breakthrough infections fewer among fully vaccinated

New components for oligonucleotide drugs show safety, efficacy in treating spinal muscular atrophy

The technology behind face masks that can diagnose COVID-19

SARS-CoV-2 test in 20 minutes with FISH

GenScript and Duke-NUS announce notice of allowance for “Surrogate Virus Neutralization Technology”

A new strategy to combat pathogenic bacterium

Scientists develop low-cost lab-on-paper device for rapid and accurate detection of SARS-CoV-2

First insights into human prion disease could help tackle neurodegenerative diseases

Study finds new clues to explain how Alzheimer’s disease spreads in the brain

MicroRNAs in urine could be a promising biomarker to diagnose brain tumors, study reveals

A comprehensive review on diagnostics of COVID-19

Scientists reveal the mechanism of liquid-liquid phase separation of SARS-CoV-2 nucleocapsid

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