Small Molecules News and Research

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Immunocompromised patients could be potential hosts for immune-escape mutants of SARS-CoV-2

In a recently published article in The New England Journal of Medicine, scientists have described how multi-mutational variants of SARS-CoV-2 may evolve in patients with immunosuppression.

5 Aug 2021

Study investigates the role of eIF4A3 protein in the growth of cancer cells

For a cell to grow and divide, it needs to produce new proteins. This also applies to cancer cells. In a new study published today in Science Advances, researchers at Karolinska Institutet in Sweden have investigated the protein eIF4A3 and its role in the growth of cancer cells.

4 Aug 2021

Study offers molecular views on how olfactory receptors work

All senses must reckon with the richness of the world, but nothing matches the challenge faced by the olfactory system that underlies our sense of smell.

4 Aug 2021

Scientist explore conserved RNA elements as potential targets for anti-SARS-CoV-2 drugs

The study, published in the journal Angewandte Chemie International Edition, identified many small molecules that bind to certain parts of the SARS-CoV-2 genome that are less likely altered by mutations using dedicated substance libraries. The scientists derived key functional units and groups in ligands for effective and safe targeting of SARS-CoV-2 RNA.

22 Jul 2021

Vitamin C and TET proteins can work together to give regulatory T cells their life-saving power

You can't make a banana split without bananas. And you can't generate stable regulatory T cells without Vitamin C or enzymes called TET proteins, it appears.

21 Jul 2021

Researchers discover major metabolite involved in regulating intestinal bacteria

Researchers at the RIKEN Center for Integrative Medical Sciences (IMS) have discovered that acetate, a major metabolite produced by some intestinal bacteria, is involved in regulating other intestinal bacteria.

19 Jul 2021

Curia to Acquire US-based LakePharma, Expanding End-to-End R&D Capabilities and Scale for Biologics

Curia today announced it has entered into a definitive agreement to acquire LakePharma Inc.

From Curia 14 Jul 2021

Biomarker discovery can open door to screening newborn babies for pyridoxine-dependent epilepsy

The door has finally opened on screening newborn babies for pyridoxine-dependent epilepsy (PDE), a severe inherited metabolic disorder. This screening promises to enable better and earlier treatment of the disease.

8 Jul 2021

Researchers introduce novel type of click reaction for living cells and organisms

Increasing our understanding of cellular processes requires information about the types of biomolecules involved, their locations, and their interactions.

2 Jul 2021

World-first study uses artificial intelligence to map the risks of ovarian cancer in women

The University of South Australia will lead a world-first study, using artificial intelligence, to map the risks of the most fatal reproductive cancer in women worldwide so it can be detected and treated earlier.

2 Jul 2021

New article focuses on drug discovery targeting SARS-CoV-2

The July edition of SLAS Discovery is a Special Edition featuring the cover article, "Development of a High-Throughput Screening Assay to Identify Inhibitors of the SARS-CoV-2 Guanine-N7-Methyltransferase Using RapidFire Mass Spectrometry" by Lesley-Anne Pearson, Charlotte J. Green, Ph.D., De Lin, Ph.D., Alain-Pierre Petit, Ph.D., David W. Gray, Ph.D., Victoria H. Cowling, Ph.D., and Euan A. F. Fordyce, Ph.D., (Drug Discovery Unit, School of Life Sciences, University of Dundee, Dundee, UK).

1 Jul 2021

New experimental model simulates the blood-brain barrier

Using an experimental model to simulate the blood-brain barrier, scientists in Sweden reported in unprecedented detail how antioxidants protect the brain from inflammation caused by neurodegenerative diseases such as Alzheimer's and Parkinson's.

1 Jul 2021

Scientists uncover new way to target a mutant protein that causes the deadliest of cancers

A new way to target a mutant protein which can cause the deadliest of cancers in humans has been uncovered by scientists at the University of Leeds.

30 Jun 2021

New biomarkers can predict HIV remission after antiretroviral therapy interruption

New biomarkers that predict HIV remission after antiretroviral therapy (ART) interruption are critical for the development of new therapeutic strategies that can achieve infection control without ART, a condition defined as functional cure.

29 Jun 2021

New discovery could yield a potential new treatment for breast cancer

A discovery by a team of researchers, led by a Geisinger professor, could yield a potential new treatment for breast cancer.

29 Jun 2021

Researchers discover new class of drugs that inhibits a 'master switch' in mantle cell lymphoma

A new class of drugs that inhibits a "master switch" involved in the vast majority of cases of mantle cell lymphoma (MCL), a fatal subtype of non-Hodgkin's lymphoma, has been discovered by researchers at Mount Sinai.

22 Jun 2021

First insights into human prion disease could help tackle neurodegenerative diseases

Surface features of human prions have been identified for the first time, which may provide key information into treatments of neurodegenerative diseases.

18 Jun 2021

Study finds new clues to explain how Alzheimer’s disease spreads in the brain

Case Western Reserve University researchers studying prions - misfolded proteins that cause lethal incurable diseases - have identified for the first time surface features of human prions responsible for their replication in the brain.

18 Jun 2021

Mouse-adapted SARS-CoV-2 and simian adenovirus vector advance COVID-19 vaccine research

A new preprint recently released on the bioRxiv* server describes the immunogenicity and protective potential of a novel adenovirus SARS-CoV-2 vaccine candidate against a form of the virus adapted to cause severe disease in mice. The findings show that this provides a useful mouse model for the study of new vaccines, in addition to demonstrating the protective efficacy of the current rhesus adenovirus vaccine candidate RhAd52.

17 Jun 2021

Reducing coronavirus-related mortality through senolytics

A study recently published in the journal Science explores the concept of senescent cells (SnC) having a hyperinflammatory response and the use of a class of small molecules called senolytics to combat this.

16 Jun 2021