Pathology News and Research

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Pathology is the study and diagnosis of disease through examination of organs, tissues, bodily fluids, and whole bodies (autopsies). The term also encompasses the related scientific study of disease processes, called General pathology. Medical pathology is divided in two main branches, Anatomical pathology and Clinical pathology. Veterinary pathology is concerned with animal disease whereas Phytopathology is the study of plant diseases.

Genetic study outlines path to personalize breast cancer risk assessment and treatment

Although the odds of developing breast cancer are nearly identical for black and white women, black women are 42 percent more likely to die from the disease. This mortality gap – driven by social and environmental, as well as biological factors – continues to persist.

4 May 2017

Molecular mechanism reprograms tumor cells to drive treatment resistance in advanced prostate cancer

Columbia University Medical Center researchers have discovered a molecular mechanism that reprograms tumor cells in patients with advanced prostate cancer, reducing their response to anti-androgen therapy.

4 May 2017

Study shows first removal of HIV-1 replication using CRISPR/Cas9, gene editing technology

A new study published in the journal Molecular Therapy reveals that HIV DNA in the genome of living animals can be removed to eliminate further infection. While a permanent cure for infection caused by HIV remains a challenge due to the ability of the virus to hide away in latent reservoirs. The study team comprising Wenhui Hu, Kamel Khalili, Laura H. Carnell, and Won-Bin Young carried out an experiment on three different animal models.

4 May 2017

Walking intervention may reestablish protective neuronal connections in older adults with MCI

Could the initiation of a simple walking exercise program help older adults to reverse declines in key brain regions? A new study led by University of Maryland School of Public Health researchers adds more information about how physical activity impacts brain physiology and offers hope that it may be possible to reestablish some protective neuronal connections.

3 May 2017

IDIBELL researchers reveal role of endoplasmic reticulum in cell death process due to starvation

Researchers from the Cell death group of the Bellvitge Biomedical Research Institute, led by Dr. Cristina Muñoz-Pinedo, have characterized the cell death process due to starvation, in which the endoplasmic reticulum plays a leading role.

3 May 2017

Study: Patients operated by higher volume mitral surgeons experience lower mortality and reoperations

Surgeons who perform more than 25 mitral valve operations a year are more likely to perform repairs that are durable, and their patients are more likely to be alive a year after the operation, than when operations are performed by lower-volume surgeons, an Icahn School of Medicine at Mount Sinai study has found.

3 May 2017

Scientists map genetic changes that help drive aggressive brain tumor

University of North Carolina Lineberger Comprehensive Cancer Center researchers and collaborators have mapped genetic changes that help drive an aggressive tumor as it develops in the brain – helping to lay the foundation for targeted treatment of the disease.

3 May 2017

Researchers uncover new mechanism that explains cause of portal hypertension

Investigators at the Medical University of South Carolina have identified a critical regulatory mechanism for the production of nitric oxide. Endothelial nitric oxide synthase is the enzyme responsible for the production of NO and its activity is tightly controlled in liver endothelial cells via a series of complex molecular mechanisms; however, in liver injury, eNOS activity, and subsequently NO production, is dysregulated.

3 May 2017

Knocking out lipid-modifying enzyme can boost post-heart attack healing, study shows

Two immune responses are important for recovery after a heart attack - an acute inflammatory response that attracts leukocyte immune cells to remove dead tissue, followed by a resolving response that allows healing.

2 May 2017

Researchers invent promising paper-based technology to kill bacteria and sanitize surfaces

Imagine wearing clothes with layers of paper that protect you from dangerous bacteria. A Rutgers-led team has invented an inexpensive, effective way to kill bacteria and sanitize surfaces with devices made of paper.

2 May 2017

Study: New gene editing strategy effectively targets cancer-causing ‘fusion genes’ in mouse models

A novel gene therapy using CRISPR genome editing technology effectively targets cancer-causing "fusion genes" and improves survival in mouse models of aggressive liver and prostate cancers, University of Pittsburgh School of Medicine researchers report in a study published online today in Nature Biotechnology.

2 May 2017

New study shows that gene editing technology can shut down HIV-1 replication in animals

A permanent cure for HIV infection remains elusive due to the virus's ability to hide away in latent reservoirs. But now, in new research published in print May 3 in the journal Molecular Therapy, scientists at the Lewis Katz School of Medicine at Temple University and the University of Pittsburgh show that they can excise HIV DNA from the genomes of living animals to eliminate further infection.

2 May 2017

Gene critical for tumor progression also encourages growth of intestinal stem cells, study shows

A gene previously identified as critical for tumor growth in many human cancers also maintains intestinal stem cells and encourages the growth of cells that support them, according to results of a study led by Johns Hopkins researchers.

28 Apr 2017

Improvements to animal testing protocols could yield more useful clinical results

The use of animals in biomedical research has long been the focus of campaigns by animal rights activists. Two leading scientists writing in the European Journal of Internal Medicine give their expert view of the importance of animal testing to medical progress and present ways it could be further improved to yield more useful clinical results.

27 Apr 2017

AI key to driving precision medicine in cancer?

It is worth noting that in the U.S. and in many countries, digital pathology is still at a very early stage, compared to many other fields that were digitized 15 or 20 years ago such as radiology. There have been some barriers to the adoption of digital pathology such as regulatory challenges that are only just now being overcome. Recently, the FDA approved the use of whole slide imaging software for primary diagnostics.

27 Apr 2017

Findings could lead to new treatments for people who overdose on popular pain reliever

Results from a new study show that after an acetaminophen overdose the p53 protein plays a key role in preventing the progression of liver damage and signaling the liver to repair itself.

27 Apr 2017

Researchers take important step toward using transplanted fetal cells to treat liver failure

In a new study, researchers demonstrate successful transplantation of fetal rat liver cells to an injured adult rat liver. The work is an important step toward using transplanted cells to treat liver failure, which currently requires an organ transplant.

26 Apr 2017

Abnormal levels of specific gut bacteria linked to chronic fatigue syndrome

Scientists at the Center for Infection and Immunity at Columbia University's Mailman School of Public Health have discovered abnormal levels of specific gut bacteria related to chronic fatigue syndrome/myalgic encephalomyelitis, or ME/CFS, in patients with and without concurrent irritable bowel syndrome, or IBS.

26 Apr 2017

Researchers discover genes linked to resilience against brain pathologies

The pathologies (damage) in the brain that stroke, Alzheimer's disease and other neurological conditions cause in older adults only partially explain the memory loss, reduced reasoning ability and other cognitive impairments that result from these conditions. Little is known about why the effects of brain pathology vary between people who develop it.

26 Apr 2017

Person's brain age could help identify risk of functional decline and mortality

Some elderly people's brains appear older than the age on their birth certificates. These people have a higher risk of developing deteriorating age-associated conditions and impairments, and even of experiencing an earlier death than expected.

25 Apr 2017

Pathology News and Research

Further Reading

Genetic study outlines path to personalize breast cancer risk assessment and treatment

Molecular mechanism reprograms tumor cells to drive treatment resistance in advanced prostate cancer

Study shows first removal of HIV-1 replication using CRISPR/Cas9, gene editing technology

Walking intervention may reestablish protective neuronal connections in older adults with MCI

IDIBELL researchers reveal role of endoplasmic reticulum in cell death process due to starvation

Study: Patients operated by higher volume mitral surgeons experience lower mortality and reoperations

Scientists map genetic changes that help drive aggressive brain tumor

Researchers uncover new mechanism that explains cause of portal hypertension

Knocking out lipid-modifying enzyme can boost post-heart attack healing, study shows

Researchers invent promising paper-based technology to kill bacteria and sanitize surfaces

Study: New gene editing strategy effectively targets cancer-causing ‘fusion genes’ in mouse models

New study shows that gene editing technology can shut down HIV-1 replication in animals

Gene critical for tumor progression also encourages growth of intestinal stem cells, study shows

Improvements to animal testing protocols could yield more useful clinical results

AI key to driving precision medicine in cancer?

Findings could lead to new treatments for people who overdose on popular pain reliever

Researchers take important step toward using transplanted fetal cells to treat liver failure

Abnormal levels of specific gut bacteria linked to chronic fatigue syndrome

Researchers discover genes linked to resilience against brain pathologies

Person's brain age could help identify risk of functional decline and mortality

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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