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Glycans strengthen interaction between viral spike proteins and ACE2 receptors on host cells

A new study shows that the ACE2 and RBD of coronavirus spike fragments have different binding strengths and dissociation rates when they are glycosylated and non-glycosylated.

13 Dec 2021

Impact of tumor environments on susceptibility and course of disease in those infected with SARS-CoV-2

A review assessed the impact of "hot" vs. "cold" immune/tumor environments (and associated therapies) on susceptibility and disease course in subjects with these two types of tumors and infected with SARS-CoV-2 to decipher the mechanisms that drive these adverse outcomes in COVID-19 infected cancer patients.

13 Dec 2021

Bioinformatics pipeline can be used to quickly identify SARS-CoV-2 therapeutics

In a new study, researchers developed a bioinformatics pipeline that uses RNA sequencing data to identify altered genes and signaling pathways affected by viral infection.

13 Dec 2021

Researchers develop a universal SARS-CoV-2 neutralizing antibody

A new study has been published in Frontiers in Immunology, where scientists developed a universal SARS-CoV-2 neutralizing antibody, MG1141A.

13 Dec 2021

MV130 immunotherapy boosts natural and vaccine-induced SARS-CoV-2 immunity in mice

A new mouse study found that intranasal administration of MV130 protected against severe acute respiratory syndrome coronavirus 2.

13 Dec 2021

Cellular properties of SARS-CoV-2 spike protein RBD in virus-infected African green monkey kidney epithelial cells

Researchers from the Biological Defence Programme of Singapore have investigated six of these antibodies.

13 Dec 2021

SARS-CoV-2-specific T cell and antibody responses in healthcare workers that suffered from COVID-19 one year ago

Researchers have been investigating the immune response in previously infected healthcare workers after they receive these vaccines.

13 Dec 2021

A method to eliminate mutants in the furin cleavage site of SARS-CoV-2 in Calu-3 cells

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12 Dec 2021

Nasal infection drives lethal lung injury due to SARS-CoV-2 in mice

A new study demonstrates lethal infection of the olfactory epithelium in a mouse model that could help understand the mechanisms of COVID-19.

12 Dec 2021

Even if SARS-CoV-2 Omicron evades antibodies, immunity still exists

Researchers determined antibody-mediated neutralization efficacy against the authentic SARS-CoV-2 Omicron variant.

12 Dec 2021

A new rapid and inexpensive PCR method to detect SARS-CoV-2 Omicron variant

A new study reports a method using four PCR tests to distinguish infection with the Omicron variant from that caused by other variants.

12 Dec 2021

New tool to help map immune escape with SARS-CoV-2 mutations

A new study discusses a computational program that can be used to substitute for actual experimental evidence of the biologic impact of new mutations.

12 Dec 2021

Infant immune system beats the adult immune system at fighting off new pathogens

As any parent knows, infants are prone to getting respiratory infections.

12 Dec 2021

Newly discovered hormone may play a key role in the development of type 1 and type 2 diabetes

A newly discovered hormone named fabkin helps regulate metabolism and may play an important role in the development of both type 1 and type 2 diabetes, according to research led by the Sabri Ülker Center for Metabolic Research at Harvard T.H. Chan School of Public Health.

12 Dec 2021

Clinical studies show enhanced responses for lymphoma patients treated with axi-cel CAR T cell therapy

Three clinical studies led by researchers at The University of Texas MD Anderson Cancer Center demonstrated enhanced responses for patients with high-risk lymphoma treated with axicabtagene ciloleucel (axi-cel) chimeric antigen receptor (CAR) T cell therapy.

12 Dec 2021

UTSW study points to a new way to fight parasitic nematode diseases

Combining two agents to block a parasitic worm's life cycle boosted survival from a potentially deadly tropical disease to 85% in animal models, far better than either treatment alone, according to a proof-of-concept study led by UT Southwestern Medical Center pharmacologists.

11 Dec 2021

UCLA research points the way towards a longer-lasting COVID vaccine

Researchers at the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research at UCLA have identified rare, naturally occurring T cells that are capable of targeting a protein found in SARS-CoV-2 and a range of other coronaviruses.

11 Dec 2021

Potentially serious side effect reported after CAR-T cell therapy for multiple myeloma

Mount Sinai scientists have become the first to report a potentially serious side effect related to a new form of immunotherapy known as CAR-T cell therapy, which was recently approved for the treatment of multiple myeloma.

11 Dec 2021

Indication of minor added benefit of nivolumab for adjuvant treatment of esophageal cancer

In an early benefit assessment, the German Institute for Quality and Efficiency in Health Care investigated whether nivolumab has an added benefit over watchful waiting in the adjuvant treatment of adults with carcinoma of the esophagus or the gastroesophageal junction and pathological residual disease after prior neoadjuvant chemoradiotherapy (CRT).

10 Dec 2021

Study finds mutational changes in Omicron variant likely increase transmissibility

A new study presented evidence for a large number of mutational changes in the Omicron variant which will likely increase its transmissibility and significantly decrease the neutralization capacity of monoclonal antibodies, leading to a decline in vaccine efficacy.

10 Dec 2021

Receptor News and Research

Glycans strengthen interaction between viral spike proteins and ACE2 receptors on host cells

Impact of tumor environments on susceptibility and course of disease in those infected with SARS-CoV-2

Bioinformatics pipeline can be used to quickly identify SARS-CoV-2 therapeutics

Researchers develop a universal SARS-CoV-2 neutralizing antibody

MV130 immunotherapy boosts natural and vaccine-induced SARS-CoV-2 immunity in mice

Cellular properties of SARS-CoV-2 spike protein RBD in virus-infected African green monkey kidney epithelial cells

SARS-CoV-2-specific T cell and antibody responses in healthcare workers that suffered from COVID-19 one year ago

A method to eliminate mutants in the furin cleavage site of SARS-CoV-2 in Calu-3 cells

Nasal infection drives lethal lung injury due to SARS-CoV-2 in mice

Even if SARS-CoV-2 Omicron evades antibodies, immunity still exists

A new rapid and inexpensive PCR method to detect SARS-CoV-2 Omicron variant

New tool to help map immune escape with SARS-CoV-2 mutations

Infant immune system beats the adult immune system at fighting off new pathogens

Newly discovered hormone may play a key role in the development of type 1 and type 2 diabetes

Clinical studies show enhanced responses for lymphoma patients treated with axi-cel CAR T cell therapy

UTSW study points to a new way to fight parasitic nematode diseases

UCLA research points the way towards a longer-lasting COVID vaccine

Potentially serious side effect reported after CAR-T cell therapy for multiple myeloma

Indication of minor added benefit of nivolumab for adjuvant treatment of esophageal cancer

Study finds mutational changes in Omicron variant likely increase transmissibility

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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