Enzyme News and Research

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UH researcher receives $2.2 million NIH grant to prevent obesity-induced cardiovascular diseases

In the early stages of obesity, endothelial cells - located in the inner layer of the arteries - become dysfunctional and lose their normal protective abilities.

12 Aug 2020

SPT enzyme can be used as metabolically responsive “switch” to slow tumor growth

The enzyme serine palmitoyl-transferase can be used as a metabolically responsive "switch" that decreases tumor growth, according to a new study by a team of San Diego scientists, who published their findings Aug. 12 in the journal Nature.

12 Aug 2020

Creating a blood test for the detection of Alzheimer’s disease

News-Medical spoke to Dr. Randall Bateman and Dr. Nicolas Barthélemy about their research on Alzheimer's disease, and their new diagnosis technique.

12 Aug 2020

C-type lectin receptors play a role in SARS-CoV-2 infection

A new study published on the preprint server bioRxiv in August 2020 confirms and extends earlier findings showing that a type of sugar-based receptor on innate immune cells promotes the entry of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) into other cells that carry the viral receptor, angiotensin-converting enzyme 2 (ACE2).

12 Aug 2020

New model predicts which COVID-19 patients are at higher risk for hospitalization

Cleveland Clinic researchers have developed and validated a risk prediction model (called a nomogram) that can help physicians predict which patients who have recently tested positive for SARS-CoV-2, the virus that causes COVID-19, are at greatest risk for hospitalization.

12 Aug 2020

SARS-CoV-2 a "swarm" of mutant viruses

In this new study, the virus was serially passaged in independent cell types in a controlled environment. The researchers found that the virus rapidly adapts to the changing conditions in culture by selecting for pre-existing species.

12 Aug 2020

New molecule shows potential therapeutic effects against arthritis

Arthritis affects almost 2% of the world's population, or some 150 million people, and currently, there is no completely effective treatment for this chronic disease. A new molecule developed in the laboratory has been shown to have potential therapeutic effects.

12 Aug 2020

Scientist explains why COVID-19 targets only some organs while others are spared

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) uses the enzyme angiotensin-converting enzyme 2 (ACE2) to enter and infect human cells. It causes COVID-19 and can lead to a multitude of complications, including multi-organ impairment, partially due to the abundant expression of ACE2 in all human tissues.

11 Aug 2020

Researchers uncover a new vulnerability in the novel coronavirus' infamous spike protein

Northwestern University researchers have uncovered a new vulnerability in the novel coronavirus' infamous spike protein -- illuminating a relatively simple, potential treatment pathway.

11 Aug 2020

1st human data for Sinovac's SARS-CoV-2 CoronaVac vaccine is out

A group of Chinese researchers recently conducted a phase 2 clinical trial to further evaluate the immunogenicity and safety of SARS-CoV-2 inactivated vaccine known as CoronaVac. The results are currently available on the medRxiv preprint server and demonstrate that the vaccine is well tolerated and without any notable dose-related safety concerns, which opens the door for phase 3 clinical trial.

11 Aug 2020

Inhaled delivery of a potent neutralizing nanobody effective against SARS-CoV-2

A recent study by researchers from China, available on the bioRxiv preprint server, shows how stable neutralizing nanobody Nb11-59 might be a promising prophylactic and therapeutic molecule against coronavirus disease (COVID-19) – especially if administered via the inhalatory route.

11 Aug 2020

Researchers identify a useful biomarker for intestinal diseases

Enzymes used by bacteria to break down mucus in the gut could provide a useful biomarker for intestinal diseases, according to new research published in Nature Communications.

11 Aug 2020

Study may help develop treatment for age-related pulmonary fibrosis

Idiopathic pulmonary fibrosis is a potentially lethal disease for which there is currently no cure and that is associated with certain mutations or advanced age.

11 Aug 2020

Researchers reveal molecular workings of a key system in learning and memory formation

One of the new realities in biomedical research is that it's increasingly difficult to use a general approach to score advances. Now, investigations into disease mechanisms, for example, are often conducted at the molecular level by specialists who dedicate years to interrogating a single protein or signaling pathway.

10 Aug 2020

Rice engineers use gene editing to facilitate drug discovery based on natural fungus

Rice University scientists have won federal support for their pursuit of novel drugs to treat human disease.

10 Aug 2020

Bioluminescent molecule in fireflies shines light on mitochondrial activity

The mitochondria provide energy for our cells, yet their role in many diseases is still poorly understood. Thanks to a bioluminescent molecule, scientists at EPFL can observe them at work in living mammals.

10 Aug 2020

DHODH inhibitor PTC299 shows potential as a COVID-19 therapeutic

As COVID-19 continues to take a heavy toll on human health and life in many parts of the world, there is still no effective antiviral drug or vaccine. This has fueled an intensive search for small molecules and proteins that can inhibit viral entry and replication.

10 Aug 2020

Speed of Novavax vaccine development does not compromise quality of the SARS-CoV-2 immunogen

A new study by researchers from the Scripps Research Institute and Novavax Inc. in the US affirms the structural integrity of the full-length SARS-CoV-2 spike glycoprotein immunogen. It enables the interpretation of immune responses to this multivalent nanoparticle immunogen. Their results are currently available on bioRxiv preprint server.

9 Aug 2020

Cutting edge synthetic peptides block SARS-CoV-2 (COVID-19)

Researchers at Ligandal Inc., the University of California San Francisco and Toyota Technological Institute at Chicago, have designed novel synthetic peptides that potently inhibit the ability of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) to infect host cells.

9 Aug 2020

NSD2 enzyme protects against cellular senescence

Researchers from Kumamoto University in Japan have used comprehensive genetic analysis to find that the enzyme NSD2, which is known to regulate the actions of many genes, also works to block cell aging.

7 Aug 2020

Enzyme News and Research

UH researcher receives $2.2 million NIH grant to prevent obesity-induced cardiovascular diseases

SPT enzyme can be used as metabolically responsive “switch” to slow tumor growth

Creating a blood test for the detection of Alzheimer’s disease

C-type lectin receptors play a role in SARS-CoV-2 infection

New model predicts which COVID-19 patients are at higher risk for hospitalization

SARS-CoV-2 a "swarm" of mutant viruses

New molecule shows potential therapeutic effects against arthritis

Scientist explains why COVID-19 targets only some organs while others are spared

Researchers uncover a new vulnerability in the novel coronavirus' infamous spike protein

1st human data for Sinovac's SARS-CoV-2 CoronaVac vaccine is out

Inhaled delivery of a potent neutralizing nanobody effective against SARS-CoV-2

Researchers identify a useful biomarker for intestinal diseases

Study may help develop treatment for age-related pulmonary fibrosis

Researchers reveal molecular workings of a key system in learning and memory formation

Rice engineers use gene editing to facilitate drug discovery based on natural fungus

Bioluminescent molecule in fireflies shines light on mitochondrial activity

DHODH inhibitor PTC299 shows potential as a COVID-19 therapeutic

Speed of Novavax vaccine development does not compromise quality of the SARS-CoV-2 immunogen

Cutting edge synthetic peptides block SARS-CoV-2 (COVID-19)

NSD2 enzyme protects against cellular senescence

Understanding the DNA Damage Response in Innate Immunity eBook

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Industry Focus eBook - Microbiome (1st edition)

Industry Focus eBook - Cell biology (5th edition)

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