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DNA origami used to analyze the ultra-fast movements of CRISPR enzymes

The remarkable genetic scissors called CRISPR/Cas9, the discovery that won the 2020 Nobel Prize in Chemistry, sometimes cut in places that they are not designed to target.

23 Feb 2021

More diverse SARS-CoV-2 variants identified within infected children than in adults

A new study describes the identification of multiple circulating variants of SARS-CoV-2 during this early pandemic period from Asia and Europe. In addition, there were multiple local introductions of different variants, that resulted in multiple waves of transmission.

23 Feb 2021

What makes viruses infectious?

In this interview, News-Medical spoke to Professor Peter Stockley about his latest research that looked at what makes viruses infectious.

23 Feb 2021

Study findings help explain the diversity of cancers in different Li-Fraumeni patients

The most frequently mutated gene in human cancers is called p53. Patients with Li-Fraumeni syndrome, which is a rare disorder that increases the risk of developing several types of cancer, often have an increased risk to develop cancers at early ages if they inherit p53 mutations.

23 Feb 2021

Study shows how m6A regulators influence metabolic heterogeneity of hepatocellular carcinoma

Cancer cells acquire growth advantages over normal cells in myriad ways. Changes in cell programming allow these cells to grow in an uncontrolled fashion, thereby forming the cancer mass.

23 Feb 2021

Influenza A virus defective interfering particles against SARS-CoV-2

In the search for a broadly acting pan-specific antiviral, an interdisciplinary team from Germany tested the previously proposed (for antiviral treatment against Influenza A infections) - Influenza A virus (IAV) defective interfering particles (DIPs). The research is published online on the bioRxiv preprint server.

23 Feb 2021

Researchers expand understanding of hop genome with implications for brewing industry

Oregon State University and U.S. Department of Agriculture researchers have significantly expanded the understanding of the hop genome, a development with important implications for the brewing industry and scientists who study the potential medical benefits of hops.

22 Feb 2021

WVU researchers set to identify SARS-CoV-2 variants, mitigate strain outbreaks

West Virginia University scientists knew it was coming. When health officials confirmed the first three cases of a COVID-19 variant in West Virginia late Friday (Feb. 19), they were not surprised.

22 Feb 2021

Insights into molecular tools shared across coronaviruses could provide potential target for COVID-19

Coronaviruses exploit our cells so they can make copies of themselves inside us. After they enter our cells, they use our cell machinery to make unique tools of their own that help them generate these copies.

22 Feb 2021

No evidence of SARS-CoV-2 fusing into the human genome

New data from researchers led by Majid Kazemian from Purdue University refutes claims from recent studies suggesting the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) could create a host-virus chimeric RNA. Their team found SARS-CoV-2 does not combine with the human genome.

22 Feb 2021

Study reveals mechanism for translation of maternally inherited mitochondrial genome

An international collaboration among researchers from Finland, Sweden, UK and the USA has captured ribosomes translating messenger RNA expressed from the maternally inherited mitochondrial genome.

22 Feb 2021

Study illuminates the role of HAND2 gene in timing of human labor

A new study illuminates how a gene called HAND2 may have a hand in the timing of human labor.

22 Feb 2021

Neanderthal gene can confer protection against severe COVID-19, finds study

A new study has detailed how some of the genes in the human genome inherited from Neanderthals appear to confer a protective effect against severe COVID-19.

22 Feb 2021

Rest during holidays has a restorative effect on DNA changes in shift workers with sleep disorder

Long-term sleep deprivation is detrimental to health, increasing the risk of psychiatric and somatic disorders, such as depression and cardiovascular diseases.

22 Feb 2021

Researchers explain SARS-CoV-2's replication-transcription complex

The current pandemic of coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is still spreading rapidly throughout the world. A new preprint on the bioRxiv* server describes the structure of an important viral non-structural protein NSP12-16 and its role in SARS-CoV-2 infection.

22 Feb 2021

Superspreader events trigger emergence of novel SARS-CoV-2 variants in USA

A team of scientists from the USA and Germany has recently studied the evolution of SARS-CoV-2 in a representative set of sequences from the USA collected between 2020 and 2021. The findings reveal that the viral genome has accumulated multiple mutations over time with only occasional loss of mutation. The main driving forces behind such genetic variations include widespread infection and superspreader events.

22 Feb 2021

Cancer cell vulnerability could be a potential target for interrupting tumor growth

Unraveling the unique characteristics of cancer cells and finding less-harmful ways to stop their growth have long been a focus for cancer researchers worldwide.

22 Feb 2021

Disinfectants could be helping bacteria to become resistant

News-Medical speaks to Professor Robert Bragg about disinfectants and how they could be helping bacteria to become resistant.

22 Feb 2021

A different strategy for wastewater detection of SARS-CoV-2

Researchers tested a variety of RNA concentration and extraction methods and assays to develop a protocol for testing SARS-CoV-2 in wastewater, which may help improve COVID-19 surveillance.

21 Feb 2021

Cissampelos pareira L. extracts demonstrate anti-SARS-CoV-2 activity in vitro

A team of scientists from India has recently investigated the antiviral potency of a traditional medicinal plant Cissampelos pareira L. in preventing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. The findings reveal that both whole-plant extracts and bioactive compounds can inhibit SARS-CoV-2 replication by modulating estrogen receptor 1 (ESR1) activity.

21 Feb 2021

Genome News and Research

DNA origami used to analyze the ultra-fast movements of CRISPR enzymes

More diverse SARS-CoV-2 variants identified within infected children than in adults

What makes viruses infectious?

Study findings help explain the diversity of cancers in different Li-Fraumeni patients

Study shows how m6A regulators influence metabolic heterogeneity of hepatocellular carcinoma

Influenza A virus defective interfering particles against SARS-CoV-2

Researchers expand understanding of hop genome with implications for brewing industry

WVU researchers set to identify SARS-CoV-2 variants, mitigate strain outbreaks

Insights into molecular tools shared across coronaviruses could provide potential target for COVID-19

No evidence of SARS-CoV-2 fusing into the human genome

Study reveals mechanism for translation of maternally inherited mitochondrial genome

Study illuminates the role of HAND2 gene in timing of human labor

Neanderthal gene can confer protection against severe COVID-19, finds study

Rest during holidays has a restorative effect on DNA changes in shift workers with sleep disorder

Researchers explain SARS-CoV-2's replication-transcription complex

Superspreader events trigger emergence of novel SARS-CoV-2 variants in USA

Cancer cell vulnerability could be a potential target for interrupting tumor growth

Disinfectants could be helping bacteria to become resistant

A different strategy for wastewater detection of SARS-CoV-2

Cissampelos pareira L. extracts demonstrate anti-SARS-CoV-2 activity in vitro

The art of CRISPR: The power and promise of gene editing eBook

Lab Matters host Harriet Gould on building a more connected lab community

The Critical Role of Sample Storage in Drug Discovery and Development

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

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