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Study reveals a new way to determine the age of insulin-storage parcels

A study in the Journal of Biological Chemistry describes a new way to determine the age of insulin-storage parcels, known as granules, and sheds light on how their age affects their release into the bloodstream.

7 Jul 2020

$5 million gift aims to propel Lyme disease research and education

To the Fairbairns, the symptoms--debilitating fatigue, joint pain, cognitive problems--were as worrisome as they were mystifying. All four members of the family had them.

6 Jul 2020

New vitamin K-based drug eliminates medication-resistant epileptic seizures in mice

In the cover article of the June 11 issue of the Journal of Medicinal Chemistry, a team of researchers at the Medical University of South Carolina, led by Sherine Chan, Ph.D., and James Chou, Ph.D., reports that a new vitamin K-based drug has proved effective in mouse models of medication-resistant seizures.

6 Jul 2020

Novel biomarkers can diagnose and assess the risk of preeclampsia

Preeclampsia is a devastating disorder that occurs very suddenly in the second half of pregnancy and causes severe health problems for both mother and baby.

3 Jul 2020

Newly discovered endometrial cancer biomarker enables early detection and treatment

A newly discovered endometrial (uterine) cancer biomarker and diagnostic method will enable detection of the tumor type that is likely to spread and recur so that clinicians can initiate treatment early and stop the cancer from attacking other parts of the body.

3 Jul 2020

New editorial published following adverse events of gene therapy clinical trial

The Editor-in-Chief of Human Gene Therapy, the first journal devoted to the field of gene therapy, and one of the world's leading experts on gene therapy have co-authored a new editorial, Moving Forward After Two Deaths in a Gene Therapy Trial of Myotubular Myopathy, in response to the news of two deaths in a now-halted gene therapy clinical trial.

3 Jul 2020

Human immune response could neutralize new G virus, shows study

Flashback to mid-March: the novel coronavirus had reached San Diego, California. Few people could get tested, and even less was known about how the virus mutated as it spread from person to person.

3 Jul 2020

Study: Variation in COVID-19 viral genome improves its ability to infect human cells

Researchers have shown that a variation in the viral genome of Covid-19 improved its ability to infect human cells and helped it become the dominant strain circulating around the world today.

3 Jul 2020

Mutated European strain of coronavirus more contagious but less potent

The coronavirus pandemic is far from over as it actively spreads across the globe. The infection toll has reached a staggering 10.84 million people since it emerged in late December 2019 in Wuhan City, China. The virus that has left the city has now spread to 188 countries and territories and has mutated, becoming more infectious.

3 Jul 2020

Researchers discover marine alga from Kiel Fjord as potential remedy against infections, skin cancer

Healing with the help of marine organisms is no utopia. Already 12 life-saving drugs, e.g. against cancer, have been developed from marine organisms and their symbiotic microbiota.

2 Jul 2020

Tiny balls of minerals are better vehicles for promising mRNA-based therapy

University of Wisconsin-Madison researchers have developed a safer and more efficient way to deliver a promising new method for treating cancer and liver disorders and for vaccination -- including a COVID-19 vaccine from Moderna Therapeutics that has advanced to clinical trials with humans.

2 Jul 2020

Newer form of SARS-CoV-2 coronavirus dominates global infections

Research out today in the journal Cell shows that a specific change in the SARS-CoV-2 coronavirus virus genome, previously associated with increased viral transmission and the spread of COVID-19, is more infectious in cell culture.

2 Jul 2020

Developing Vaccines and Therapeutics by Exploiting Structure in Spherical Nucleic Acids

An interview discussing the use of spherical nucleic acids (SNAs) and what they show about the importance of structure in pharmaceutical development.

From Pittcon 2 Jul 2020

Structure of the full SARS-CoV-2 RNA genome in infected cells

The current COVID-19 pandemic caused by a single-stranded RNA virus, thought to have jumped across species barriers to infect humans, has spread rapidly across the globe infecting over 10 million individuals. The virus, now known as the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is the causative agent of COVID-19 disease. COVID-19 disease is a respiratory illness where symptoms can range from very mild to severe and include fever, coughing, a sore throat, and shortness of breath.

2 Jul 2020

Scientists find coronavirus' Achilles' heel

A team of scientists at the University of California San Francisco has found out how SARS-CoV-2, the virus that causes the coronavirus disease (COVID-19) invades proteins in the cells that serve as master regulators of key cellular processes.

1 Jul 2020

Researchers develop a potential treatment approach for Pelizaeus-Merzbacher disease

A team led by Case Western Reserve University medical researchers has developed a potential treatment method for Pelizaeus-Merzbacher disease (PMD), a fatal neurological disorder that produces severe movement, motor and cognitive dysfunction in children.

1 Jul 2020

Exercise can slow or prevent macular degeneration

Exercise can slow or prevent the development of macular degeneration and may benefit other common causes of vision loss, such as glaucoma and diabetic retinopathy, new research suggests.

1 Jul 2020

GIRK channel activator can provide potential treatments for brain disorders

Potassium channels play an important role in controlling the electrical activity of neurons in the brain.

1 Jul 2020

Study reveals a new target for tuberculosis drug development

Biology students and faculty members from The University of Texas at El Paso have discovered a new target for tuberculosis drug development.

1 Jul 2020

New approach holds incredible potential for developing new therapeutics

Nearly every drug that is, or has ever been, used was derived from nature -- harnessing compounds created by organisms over eons to fight diseases. But decades ago, biochemists postulated that it might be possible to design a new drug from scratch by linking up amino acids in precise ways.

30 Jun 2020