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New research explores the unique effects of ADHD medications on Drosophila brain cells

The effect of two drugs used for the treatment of attention-deficit/hyperactivity disorder.

15 Nov 2023

COVID-19 pandemic slowed progress toward ending HIV epidemic in the U.S.

The COVID-19 pandemic slowed previous gains made in controlling HIV blood levels and worsened health disparities, according to UC Francisco researchers leading the largest U.S. evaluation of the impact of the public health crisis on people with HIV.

14 Nov 2023

Intestinal MCT1 plays a crucial role in sex-dependent metabolic regulation

Monocarboxylate transporter 1 (MCT1) plays a crucial role in the transport of lactate, pyruvate, ketone bodies, and short-chain fatty acids (SCFA), as well as MCT1-targeted drugs in various tissues.

14 Nov 2023

Dietary sodium intake significantly impacts blood pressure, reveals comprehensive study

The JAMA study finds individual blood pressure responses to dietary sodium variations are consistent across different subgroups, including those on antihypertensive medications, suggesting a universal effect of sodium intake on blood pressure in a diverse population.

14 Nov 2023

Existing drug that targets sleeping cells could hold the key to treating lower back pain

An existing drug that targets senescent, or sleeping cells could provide the answer to treating lower back pain, according to a new study.

14 Nov 2023

Study provides insights into longevity of neutralizing antibodies in HIV-1 infection

An international team has for the first time researched the longevity of neutralizing antibodies in HIV-1-infected people.

14 Nov 2023

Circular extrachromosomal DNA identified as a potential target for new medulloblastoma therapies

A study of newly created databases of medulloblastoma has found that patients with tumors containing circular extrachromosomal DNA - loops of DNA found outside of regular chromosomes - are twice as likely to relapse and three times as likely to die within five years of diagnosis.

14 Nov 2023

COVID-19 triggers epigenetic alterations that drive lung damage and fatalities

The COVID-19 disease, due to infection with the SARS-CoV2 virus, became an international pandemic in 2020. To date, more than 770 million people have suffered from the disease and nearly 7 million of them have lost their life.

14 Nov 2023

Self-perception of health influences physical activity levels in older adults with arthritis

People with arthritis who report more negative feelings about how they are aging tend to get less physical activity and perceive themselves as less healthy, according to a new study by researchers at Hospital for Special Surgery (HSS) and Weill Cornell Medicine.

14 Nov 2023

Cancer stem cells induce macrophage aging, creating conditions for tumor formation

Cancer stem cells cause the aging of macrophages in mice with healthy immune systems, creating conditions for the formation of tumors.

14 Nov 2023

Neural circuits respond to rapid dopamine surges

Researchers assess the pharmacodynamics of dopamine signaling, brain connectivity/activity, and self-documented 'high' following methylphenidate exposure.v

14 Nov 2023

New gel delivery system overcomes challenges of intratumoral cancer immunotherapy

Intratumoral therapy – in which cancer drugs are injected directly into tumors – is a promising treatment option for solid cancers but has shown limited success in clinical trials due to an inability to precisely deliver the drug and because most immunotherapies quickly dissipate from the site of injection.

13 Nov 2023

Discovery of two new enzymes offers easier ways to study and manufacture complex natural chemicals

Slumbering among thousands of bacterial strains in a collection of natural specimens at The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology, several fragile vials held something unexpected, and possibly very useful.

13 Nov 2023

"Christchurch mutation" can block detrimental effects of Alzheimer’s risk factor

Researchers at Gladstone Institutes have discovered that a rare genetic variant known as the "Christchurch mutation" can block detrimental effects of apolipoprotein E4, the best-established risk factor for the most common form of Alzheimer's disease.

13 Nov 2023

Unlocking the cure for hepatitis B virus: Challenges and opportunities

Hepatitis B virus (HBV) is a significant public health problem, with over 296 million people chronically infected worldwide.

13 Nov 2023

Initial high-risk antibody profile for antiphospholipid syndrome tends to remain high in pediatric patients, study finds

A new study by Hospital for Special Surgery (HSS) investigators has found that an initial high-risk antibody profile for antiphospholipid syndrome (APS) tended to remain high in pediatric patients.

13 Nov 2023

KAIST researchers develop an IV needle that irreversibly softens upon insertion

Intravenous (IV) injection is a method commonly used in patient's treatment worldwide as it induces rapid effects and allows treatment through continuous administration of medication by directly injecting drugs into the blood vessel.

13 Nov 2023

Exploring the use of psychedelics as novel treatments for psychiatric disorders

Psychedelic compounds such as psilocybin, a substance found in various mushroom species, are garnering more research support as novel treatments for psychiatric disorders, but questions remain concerning who they may help the most.

13 Nov 2023

Willow bark may be the source of a new antiviral drug

Scientists have found that specially processed samples of willow bark extract have an antiviral effect which isn’t seen in already known medical compounds from willow bark, such as salicylic acid, the precursor to modern aspirin.

13 Nov 2023

New hope for TB patients as UNITE4TB launches clinical trial program

Today, UNITE4TB, an international public-private partnership striving to fast-track the development of innovative Tuberculosis (TB) treatments, announced the start of its phase 2B/C clinical trial program with the first participant enrolled at its trial site in Cape Town, South Africa.

13 Nov 2023

Drugs News and Research

New research explores the unique effects of ADHD medications on Drosophila brain cells

COVID-19 pandemic slowed progress toward ending HIV epidemic in the U.S.

Intestinal MCT1 plays a crucial role in sex-dependent metabolic regulation

Dietary sodium intake significantly impacts blood pressure, reveals comprehensive study

Existing drug that targets sleeping cells could hold the key to treating lower back pain

Study provides insights into longevity of neutralizing antibodies in HIV-1 infection

Circular extrachromosomal DNA identified as a potential target for new medulloblastoma therapies

COVID-19 triggers epigenetic alterations that drive lung damage and fatalities

Self-perception of health influences physical activity levels in older adults with arthritis

Cancer stem cells induce macrophage aging, creating conditions for tumor formation

Neural circuits respond to rapid dopamine surges

New gel delivery system overcomes challenges of intratumoral cancer immunotherapy

Discovery of two new enzymes offers easier ways to study and manufacture complex natural chemicals

"Christchurch mutation" can block detrimental effects of Alzheimer’s risk factor

Unlocking the cure for hepatitis B virus: Challenges and opportunities

Initial high-risk antibody profile for antiphospholipid syndrome tends to remain high in pediatric patients, study finds

KAIST researchers develop an IV needle that irreversibly softens upon insertion

Exploring the use of psychedelics as novel treatments for psychiatric disorders

Willow bark may be the source of a new antiviral drug

New hope for TB patients as UNITE4TB launches clinical trial program

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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