Central Nervous System News and Research

RSS

Gut microbes may help explain why obesity and type 2 diabetes become harder to reverse

This review describes how gut microbial messengers, including SCFAs, microbiota-modified bile acids, neuroactive metabolites, and extracellular vesicles, may shape obesity and type 2 diabetes through the microbiota-gut-brain axis.

17 Jun 2026

Cerebral organoid model offers insights into the mechanisms of Ebola virus persistence

Following infection, Ebola virus can survive unnoticed in the human body for months or even years, hiding in areas with little immune surveillance like the central nervous system.

17 Jun 2026

Preoperative radiation boosts immunotherapy response in brain metastases

A new study led by researchers at The University of Texas MD Anderson Cancer Center demonstrated that pre-operative radiation therapy for brain metastases not only targets tumor cells directly but also can activate immune pathways that can make tumors more receptive to immunotherapy.

17 Jun 2026

AI-designed drug for Parkinson's begins first human trial

Insilico Medicine ("Insilico", HKEX: 3696), a clinical-stage biotechnology company powered by generative artificial intelligence (AI), today announced it has achieved the first clinical milestone in its co-development collaboration with Hygtia Therapeutics with the completion of first-in-human dosing in the Phase I study of ISM8969.

17 Jun 2026

First-in-the-world gene therapy delivers missing gene directly to infant’s brain, marking historic milestone in precision medicine

An eight-month-old baby from Israel has become the first human ever to receive an experimental gene therapy designed to replace a missing gene responsible for a devastating neurological disease that until now offered no hope of survival.

11 Jun 2026

Scientists reveal how cGAS-STING fuels brain inflammation and neurodegeneration

The cGAS-STING pathway is emerging as a key driver of chronic neuroinflammation through its effects on glial activation, neuronal stress, blood-brain barrier integrity, and type I interferon signaling. The review highlights why selective, context-dependent modulation of cGAS-STING could help treat neurodegenerative diseases, while preserving its essential roles in antiviral defense and tumor surveillance.

10 Jun 2026

New AI system classifies brain tumors with unprecedented accuracy

Experts in Heidelberg have developed an AI system that can classify brain tumors with unprecedented accuracy using standard microscopic tissue sections.

10 Jun 2026

Acupuncture improves muscle function recovery in stroke patients

Paralysis on one side of the body is common after stroke. A new study in CNS Neuroscience & Therapeutics demonstrates that acupuncture can significantly improve muscle function recovery in patients who experienced a stroke, with this recovery correlating to increases in grey matter volume in certain regions of the brain related to cognitive-motor integration.

3 Jun 2026

Higher-dose ocrelizumab depletes more B cells but does not slow MS progression

Higher-dose ocrelizumab produced greater peripheral B-cell depletion than the approved 600 mg regimen in two phase 3b trials of relapsing and primary progressive multiple sclerosis. However, the higher doses did not significantly delay disability progression, supporting the 600 mg dose as the current standard regimen with a favorable benefit-risk profile.

31 May 2026

Miniature lab grown circuits unlock hidden recovery paths for paralysis

Cambridge scientists have grown miniature circuits in the lab that mimic how the brain and spinal cord connect up, which underlies our movements. They used this model to show how damage to these connections previously considered 'irreversible' could, in fact, be reversible.

28 May 2026

Scientists rethink GLP-1 delivery to improve dosing, tolerability, and adherence

The review highlights nanocarriers, microspheres, hydrogels, microneedles, long-acting formulations, and co-formulations as promising but mostly early-stage strategies that still require stronger long-term clinical evidence.

27 May 2026

Gum disease pathogen may drive Alzheimer’s through microglial ferroptosis pathway

Alzheimer's disease (AD), the leading cause of dementia, is projected to affect 152 million individuals worldwide by 2050; yet its pathogenesis remains poorly understood and effective treatments are lacking.

24 May 2026

New biomarker predicts therapy response for hard-to-treat childhood cancers

A study by researchers at the University of Birmingham has identified a new biomarker for response to a specific cancer therapy, treating children with Ewing Sarcoma and other tumor types.

22 May 2026

Vitamin B12 analog targets deadly brain cancer cells

A new research paper was published in Volume 13 of Oncoscience on April 2, 2026, titled "Selective blood–brain barrier penetration and tumor targeting of nitrosylcobalamin in glioblastoma: Pharmacokinetics, tissue distribution, and synergistic activity with trail and temozolomide."

21 May 2026

New study shows how exercise hormone reduces multiple sclerosis symptoms

A new study offers clues as to why exercise can improve neurological symptoms in people with multiple sclerosis (MS).

21 May 2026

Gut microbiome metabolite butyrate relieves chronic jaw joint pain

Temporomandibular joint (TMJ) pain is associated with disrupted gut microbiome metabolites. Researchers reveal that butyrate, administered as tributyrin, alleviates pain by restoring histone acetylation and reversing gene regulatory changes in the brain.

18 May 2026

Rocket Science Health validates targeted olfactory-cleft deposition in non-human primates ahead of the 4th Nasal Formulation & Delivery Summit

As the pace of modern drug discovery accelerates, the industry is increasingly recognizing that a breakthrough molecule is only as effective as its ability to reach the target site.

From Hanson Wade Group - 4th Nasal Formulation & Delivery Summit 15 May 2026

New research reassures mothers on NSAID safety during the first trimester

Nonsteroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen and naproxen, taken during the first trimester of pregnancy are not associated with an increased risk of major birth defects, according to a new study published May 14th in the open-access journal PLOS Medicine by Sharon Daniel of Ben-Gurion University of the Negev and Clalit Health Services, Beer-Sheva, Israel, and colleagues.

15 May 2026

Research identifies significant spike in neurological disorders during the covid-19 pandemic

In 2021, neurological diseases affected 3.40 billion individuals worldwide, corresponding to 43.1 % of the global population. In China, rapid demographic shifts and lifestyle changes have contributed to a continued rise in the burden of stroke, dementia, and Parkinson's disease-a trend expected to persist.

15 May 2026

New FUSILLI tool improves gene fusion detection in pediatric leukemia

Researchers have introduced a novel diagnostics method that can more sensitively detect gene fusions in B-cell acute lymphoblastic leukemia (B-ALL), the most common type of pediatric cancer, compared to other publicly available fusion detection algorithms.

15 May 2026

Central Nervous System News and Research

Gut microbes may help explain why obesity and type 2 diabetes become harder to reverse

Cerebral organoid model offers insights into the mechanisms of Ebola virus persistence

Preoperative radiation boosts immunotherapy response in brain metastases

AI-designed drug for Parkinson's begins first human trial

First-in-the-world gene therapy delivers missing gene directly to infant’s brain, marking historic milestone in precision medicine

Scientists reveal how cGAS-STING fuels brain inflammation and neurodegeneration

New AI system classifies brain tumors with unprecedented accuracy

Acupuncture improves muscle function recovery in stroke patients

Higher-dose ocrelizumab depletes more B cells but does not slow MS progression

Miniature lab grown circuits unlock hidden recovery paths for paralysis

Scientists rethink GLP-1 delivery to improve dosing, tolerability, and adherence

Gum disease pathogen may drive Alzheimer’s through microglial ferroptosis pathway

New biomarker predicts therapy response for hard-to-treat childhood cancers

Vitamin B12 analog targets deadly brain cancer cells

New study shows how exercise hormone reduces multiple sclerosis symptoms

Gut microbiome metabolite butyrate relieves chronic jaw joint pain

Rocket Science Health validates targeted olfactory-cleft deposition in non-human primates ahead of the 4th Nasal Formulation & Delivery Summit

New research reassures mothers on NSAID safety during the first trimester

Research identifies significant spike in neurological disorders during the covid-19 pandemic

New FUSILLI tool improves gene fusion detection in pediatric leukemia

Event guide: The 7th CNS Drug Delivery Summit eBook

How ELRIG Is Helping Mid-Career Scientists Navigate Leadership, Career Change and Redundancy

The role of UV-Vis in biopharma QC

Applications Engineer

Latest News