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Houston researcher identifies new targets for fatal rhabdomyosarcoma

A cancer researcher at the University of Houston is reporting what makes malignant soft tissue cancer grow in children, identifying key mechanisms and molecular targets to prevent tumor progression in patients in future therapies of the fatal rhabdomyosarcoma.

9 Jun 2026

Three-drug strategy forces pancreatic tumors into lasting regression

A triple-targeted preclinical therapy combining daraxonrasib, afatinib, and SD36 drove durable pancreatic cancer regression by blocking KRAS/RAS, EGFR/HER2, and STAT3 signaling. The approach prevented treatment resistance across mouse and human tumor-derived models, but remains preclinical and requires more clinically suitable drug combinations before human testing.

2 Jun 2026

Mesenchymal drift may explain how aging cells lose their identity

Mesenchymal drift may help explain how cells lose stable identity and acquire pro-fibrotic, inflammatory mesenchymal traits during aging. The review proposes MD as a unifying framework that links multiple hallmarks of aging and highlights partial reprogramming as a potential, but still preclinical, way to counteract this process.

1 Jun 2026

New nutrient-sensing mechanism offers hope for neurodegenerative diseases

Researchers from the University of Cambridge highlight new ways that neurons and many cell types use to sense nutrients - opening potential novel therapeutic avenues for disorders such as Alzheimer's and Parkinson's disease.

28 May 2026

Blocking sugar modification could boost breast cancer immunotherapy success

Immunotherapies such as so-called checkpoint inhibitors activate the body's own immune system to fight cancer cells and have revolutionized the treatment of many types of tumor.

27 May 2026

Explainable AI could make breast cancer drug predictions safer and clearer

AI-driven genomic analysis could help researchers identify existing drugs that may be repurposed for subtype-specific breast cancer treatment. The review proposes an interpretability-driven framework that links multi-omics data, mechanistic validation, and clinical translation to make AI predictions more transparent and clinically useful.

22 May 2026

Phase two clinical trial demonstrates dramatic mobility gains in children with severe fibrous dysplasia

Fibrous dysplasia is a rare skeletal disorder in which normal bone is gradually replaced by weak fibro-osseous tissue, leading to fractures, pain, deformities, and severe mobility impairment. In many patients, diseased bone tissue produces excessive amounts of fibroblast growth factor-23 (FGF23), a hormone that causes phosphate loss through the kidneys.

21 May 2026

Restoring ADAR2 enzyme reduces metastatic spread in osteosarcoma

Osteosarcoma is the most common primary bone cancer in children, adolescents, and young adults. Although chemotherapy and surgery have improved survival for localized disease, outcomes remain poor when tumors spread to the lungs or return after treatment.

20 May 2026

Study reveals cellular mechanisms driving resistance to targeted cancer therapies

Despite impressive innovations in medicine, most advanced-stage cancers still carry a grim prognosis. Developing more effective treatments requires a deeper understanding of the cellular processes that drive the formation and growth of common cancers.

20 May 2026

How antibody-drug conjugates are redefining targeted cancer therapy

Antibody-drug conjugates are rapidly expanding cancer therapies, with 19 approved globally and many more in development, but their success depends on better targets, payloads, linkers, dosing, and patient selection. The Cell review shows that next-generation ADCs could widen treatment options, but safety, resistance, tumor heterogeneity, and clinical translation remain major barriers.

19 May 2026

Prenatal chemical mixtures may influence fetal growth and placental health

Common environmental chemicals could affect birthweight and placental function, according to a new study published in Environmental Science & Technology and led by the Barcelona Institute for Global Health (ISGlobal), a centre supported by "la Caixa" Foundation. Conducted within the Barcelona Life Study Cohort (BiSC), the research underscores the importance of considering real-life exposure to complex chemical mixtures and highlights the role of angiogenic biomarkers in linking these exposures to fetal development.

17 May 2026

How Andes virus super-spreaders reveal the risk behind the MV Hondius hantavirus cluster

A 2020 NEJM study of the 2018 to 2019 Epuyén outbreak showed that Andes virus spread from one zoonotic introduction into four generations of human infection, causing 34 cases and 11 deaths. The findings are newly relevant after WHO reported an ANDV cluster linked to the MV Hondius cruise ship, where close indoor exposure may have enabled onboard human-to-human transmission.

14 May 2026

Study links mitochondrial health to effectiveness of anti-aging pathways

Mississippi State University biologist Jean-Francois Gout's contributions to a study highlighting key advances in the complexity of aging now are published in Science Advances, a leading peer-reviewed journal of the American Association for the Advancement of Science.

7 May 2026

Liquid biopsy predicts immune response in high-risk breast cancer patients

Immunotherapy has become a standard of care in treating high-risk, early-stage breast cancers, yet it has had limited success in shrinking tumors.

30 Apr 2026

How cost, access, and awareness barriers are slowing BRCA testing

This study analyzes BRCA testing patterns in U.S. breast cancer patients, highlighting barriers and disparities in access to genetic testing and precision care.

29 Apr 2026

Researchers discover how cell membrane composition drives cancer proliferation

Cells are enveloped by a lipid membrane that gives them structure and provides a barrier between the cell and its environment.

17 Apr 2026

Circulating exosomal microRNAs offer a non-invasive biomarker for MASLD

Metabolic dysfunction-associated steatotic liver disease (MASLD) has become a global public health challenge with rapidly rising prevalence, especially in China. Despite advances in treatment, the underlying molecular mechanisms remain incompletely understood. A new research article published in the Chinese Medical Journal on March 16, 2026, provides critical insights into the role of exosomal microRNAs (miRNAs) in MASLD pathogenesis.

17 Apr 2026

Study finds long COVID leaves a distinct immune signature in the blood

Researchers identified a small panel of inflammatory and neurology-related blood proteins that may help distinguish long COVID from recovery or no prior infection, while also showing that booster vaccination did not appear to worsen these protein responses in this cohort. The study also found that immune responses after reinfection differed from those seen after the first SARS-CoV-2 infection, suggesting altered long-term immune behavior in some previously infected individuals.

14 Apr 2026

SARS-CoV-2 rarely reaches first-trimester placentas but still disrupts early pregnancy immunity

Researchers analyzing 761 first-trimester pregnancies found that SARS-CoV-2 was rarely detected in placental tissues, suggesting in utero transmission early in pregnancy is uncommon. However, maternal infection was linked to immune dysregulation at the maternal-fetal interface, altered trophoblast signaling, and inflammatory changes that could affect placental development.

14 Apr 2026

Large US study finds never-married adults face higher risk for most major cancers

A large US population-based study found that never-married adults had higher cancer incidence than ever-married adults across most cancer types, with the largest disparities seen in older adults and in Black men. The pattern was especially strong for HPV-related, tobacco-related, and several reproductive cancers, suggesting marital status may act as an important social marker of cancer risk.

9 Apr 2026