Hormone Replacement Therapy News and Research

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Hormone Replacement Therapy (HRT) sometimes called estrogent replacement therapy or ERT, refers to a woman taking supplements of hormones such as estrogen alone or estrogen with another hormone called progesterone (progestin in its synthetic form). HRT replaces hormones that a woman’s body should be making or used to make.

Higher BMI, not menopause age, increases hypothyroidism risk

Researchers analyzed over 15,000 postmenopausal Canadian women to investigate whether age at natural menopause influences the risk of developing overt hypothyroidism. The study found no association, but higher BMI was linked to increased hypothyroidism risk.

29 May 2025

Early menopause increases risk of fatty liver disease and metabolic disorders

Women who experience menopause before the age of 50 - and especially before the age of 45 - are more likely to develop fatty liver disease and its related metabolic risk factors within one year after menopause, according to research presented at the first Joint Congress between the European Society of Paediatric Endocrinology (ESPE) and the European Society of Endocrinology (ESE).

11 May 2025

Ovary and fallopian tube removal linked to lower death risk in BRCA carriers with breast cancer

Women diagnosed with breast cancer who carry particular BRCA1 and BRCA2 genetic variants are offered surgery to remove the ovaries and fallopian tubes as this dramatically reduces their risk of ovarian cancer.

8 May 2025

Progesterone-only contraceptive pill linked to increased asthma attacks in some women

A major study of around 260,000 women shows that taking the progesterone-only contraceptive pill can increase asthma attacks in some women.

7 May 2025

Early menopause linked to worse cognitive function in later life

A team of researchers from the Tohoku University Graduate School of Medicine and Tokyo Metropolitan Institute of Medical Science found that women who entered menopause before the age of 40 had worse cognitive outcomes than women who entered menopause after the age of 50.

16 Apr 2025

Study explores how sex chromosomes and hormones influence immune responses

Women have a higher proportion of key immune cells between puberty and menopause, which may be linked to the sex hormone estrogen and explain why they are less susceptible to certain infectious diseases than men, according to a new study led by researchers at UCL.

27 Mar 2025

Oophorectomy linked to higher risk of heart failure in women

Women of childbearing age who had both ovaries removed, in a procedure called bilateral oophorectomy, were more likely to develop heart failure later in life, according to a study being presented at the American College of Cardiology's Annual Scientific Session (ACC.25).

20 Mar 2025

Research shows epigenetic aging in the blood as potential breast cancer marker

A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) on December 5, 2024, Volume 16, Issue 22, titled "DNA-methylation age and accelerated epigenetic aging in blood as a tumor marker for predicting breast cancer susceptibility."

21 Jan 2025

Are individuals with advanced breast cancer more likely to have cardiovascular disease?

Research shows that patients with advanced breast cancer have higher odds of cardiovascular disease, emphasizing the importance of personalized screening.

7 Jan 2025

Puberty blockers and gender-affirming hormones rarely prescribed to transgender youth

Puberty blockers and gender-affirming hormones are rarely prescribed to U.S. transgender and gender diverse (TGD) adolescents, according to a new study from researchers at Harvard T.H. Chan School of Public Health, Harvard Pilgrim Health Care Institute, and FOLX Health.

6 Jan 2025

Study reveals potential Alzheimer’s risk in women using hormone replacement therapy

Hormone Replacement Therapy involves giving women synthetic oestrogen to replace depleting hormone levels and thus alleviate menopausal symptoms.

23 Dec 2024

Depression genes amplify women's heart disease risk

Study reveals a sex-specific link between genetic risks for psychiatric disorders and cardiovascular diseases (CVDs), with women showing a higher risk of atrial fibrillation, coronary artery disease, and heart failure linked to genetic predisposition to major depression. Menopause and modifiable factors like BMI and smoking amplify these risks.

8 Dec 2024

Study reveals varied risks of hormone treatments for menopausal symptoms

Researchers at Uppsala University have analyzed the effects of seven different hormone treatments for menopausal symptoms on the risk of blood clots, stroke and heart attack.

28 Nov 2024

Specific HRT tablets linked to increased risk of heart disease and blood clots

Certain hormone replacement therapy (HRT) tablets containing both estrogen and progestogen are associated with a higher risk of heart disease and rare but serious blood clots known as venous thromboembolism (VTE) in women around the age of menopause, finds a study from Sweden published by The BMJ today.

28 Nov 2024

History of endometriosis and fibroids linked to higher long-term risk of early death

Researchers examine the impact of endometriosis and uterine fibroids on the risk of early death.

25 Nov 2024

The Women's Health Initiative continues to provide a wealth of nutrition insights

The Women's Health Initiative (WHI), a landmark study among 161,808 postmenopausal women that has been ongoing for more than 40 years, continues to contribute a wealth of insights towards the advancement of the science of nutrition.

18 Oct 2024

Premature ovarian insufficiency in women linked to greater risk of severe autoimmune conditions

Severe autoimmune conditions such Type I diabetes, Addison's disease, lupus and inflammatory bowel disease, are between two to three times more common in women who have been diagnosed with premature ovarian insufficiency (POI) compared to the general population.

25 Sep 2024

Understanding the impact of BMI on colorectal cancer risk in Asia

Researchers report that body mass index values in Asians population may predict the risk of developing colorectal cancer.

4 Sep 2024

$Gut microbiota linked to fracture risk: Study reveals key microbial associations$

Gut microbiota linked to fracture risk: Study reveals key microbial associations

The association between gut microbiota (GM) composition and incident fractures in the Finnish Risk Monitoring Program (FINRISK) 2002 cohort.

19 Aug 2024

Menopause myths: Separating fact from fiction

Many women approach menopause with anxiety about the future. You've probably heard your grandmother, mother, or aunts lament about menopause, aka "the change," as a stressful time full of hot flashes, weight gain, and plummeting sex drive.

6 Aug 2024