International Classification of Diseases News and Research

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Strong heart health lowers long-term death risk in cancer survivors

Higher Life’s Simple 7 cardiovascular health scores were associated with lower long-term all-cause and cancer mortality in cancer survivors from a large Italian cohort. Inflammation, resting heart rate, and vitamin D statistically explained a substantial share of these associations, supporting shared cardiometabolic pathways across cancer and cardiovascular disease.

17 Dec 2025

Restless legs syndrome linked to higher Parkinson’s disease risk

The study shows restless legs syndrome is associated with higher Parkinson's disease incidence, raising questions about treatment impacts on symptoms.

5 Dec 2025

Acute and chronic depression involve different mechanisms in the brain

A new study investigating neuroinflammation in the ventral tegmental area (VTA) of the brain, a small, midbrain dopaminergic region, has found that acute and chronic depression are associated with distinct pathophysiological mechanisms.

18 Nov 2025

Veterans deployed to Iraq and Afghanistan face higher risk of chronic respiratory conditions

U.S. Veterans who served in Operation Iraqi Freedom (OIF) and Operation Enduring Freedom (OEF) face an increased risk of developing several chronic respiratory conditions, according to new research presented at the 2025 Annual Scientific Meeting of the American College of Allergy, Asthma and Immunology (ACAAI) in Orlando.

6 Nov 2025

Obesity’s health risks shift with age and sex, new genetic study reveals

Using a new time-resolved Mendelian randomization approach in over 360,000 UK Biobank participants, Karlsson et al. revealed that the causal impact of obesity changes across life, with distinct age- and sex-specific risk patterns for diabetes, heart disease, atrial fibrillation, and osteoarthritis.

27 Oct 2025

MRI age clocks reveal how each organ ages differently and predict who develops disease or lives longer

Researchers developed seven MRI-based biological age clocks across major organs using UK Biobank imaging, linking each to proteins, metabolites, genetics, disease risks, mortality, and cognitive decline. These organ-specific age gaps reveal how uneven aging shapes vulnerability to conditions such as diabetes, hypertension, and dementia, opening new paths for precision prevention and clinical trial stratification

19 Oct 2025

Depression during pregnancy raises risk of gestational diabetes

Findings indicate that antenatal depression increases the risk of gestational diabetes, underscoring the need for early intervention and lifestyle support.

8 Oct 2025

Genetic risk scores fail to predict survival after diagnosis

Research indicates that disease susceptibility genetics poorly predict survival, while longevity PGSs offer stronger associations with post-diagnosis mortality.

2 Oct 2025

Nirsevimab sharply cuts RSV hospitalizations in U.S. infants during the 2024–2025 season

In a nationwide EHR cohort of over 400,000 U.S. infants during the 2024–2025 RSV season, nirsevimab use was linked to a 77% lower risk of RSV-related hospitalization. The study also found reduced ICU admissions and intubations, supporting broad seasonal protection in routine care.

28 Sep 2025

Alcohol raises dementia risk at every level of drinking, genetic study shows

Researchers using two major cohorts and Mendelian randomization found that alcohol consumption, whether light or heavy, raises the risk of dementia. Genetic evidence shows no safe level of drinking, challenging the belief that moderate intake protects brain health.

25 Sep 2025

Scientists use blood chemistry to predict disease years before it strikes

Researchers built the largest plasma metabolome-phenome atlas using 274,241 UK Biobank participants, linking over 73,000 metabolite-trait and 52,000 metabolite-disease associations. The study shows metabolic risk scores can predict diseases years before diagnosis, with strong accuracy for diabetes and kidney complications.

22 Sep 2025

Hyperemesis gravidarum associated with increased neuropsychiatric disorders in pregnancy

The largest study on pregnant women with excessive nausea and vomiting (hyperemesis gravidarum) has identified increased risks of numerous neuropsychiatric and mental health outcomes.

18 Sep 2025

AI model maps lifetime disease risks to transform future healthcare planning

Researchers developed Delphi-2M, a transformer-based AI trained on UK Biobank and Danish health data to predict and simulate lifetime trajectories for 1,256 diseases. It accurately forecasted long-term multimorbidity risks, generated synthetic health records, and highlighted comorbidity patterns while exposing key biases.

18 Sep 2025

New diagnostic code brings recognition and support for Gulf War Illness

Gulf War illness (GWI), the chronic, debilitating condition linked to military service in the 1990-1991 Gulf War, will receive a dedicated diagnostic code in the October 2025 release of the International Classification of Diseases (ICD-10-CM).

11 Sep 2025

Planetary health diet links to longer life and lower emissions

Greater adherence to the Planetary Health Diet was linked to lower all-cause, cancer, and respiratory mortality across large US and UK cohorts, supported by a meta-analysis of 37 studies. Diets higher in PHD foods also had smaller greenhouse gas footprints, reinforcing health and environmental benefits.

9 Sep 2025

Gut disorders forecast Alzheimer’s and Parkinson’s risk years before diagnosis

Study maps clinical, genetic, and proteomic links between gut-brain disorders and neurodegeneration, showing how diabetes, vitamin D deficiency, and bowel disorders forecast Alzheimer’s and Parkinson’s years in advance. Multimodal models in biobanks highlight early detection and personalized prevention opportunities.

28 Aug 2025

Advanced form of AI opens door to personalized cancer care

What if a computer could read a patient's medical notes and help doctors determine important information for their treatment?

1 Aug 2025

Allergies linked to lower lung cancer risk, new study finds

A meta-analysis of nearly 3.9 million participants shows people with allergies have significantly lower odds of developing lung cancer. Allergic rhinitis is particularly protective, while eczema’s effect appears limited to men.

20 Jul 2025

Shingles and RSV vaccines with AS01 adjuvant reduce dementia risk

Researchers found that older adults who received AS01-adjuvanted shingles or RSV vaccines had a significantly lower risk of developing dementia within 18 months compared to flu vaccine recipients. The protective effect is likely linked to the AS01 adjuvant itself, highlighting new avenues for dementia prevention.

30 Jun 2025

America slashes heart attack deaths but faces surge in deadly heart failure and arrhythmias

U.S. heart disease mortality has dropped 66% since 1970, mainly due to fewer ischemic heart disease deaths. However, deaths from heart failure, arrhythmias, and hypertensive heart disease have risen sharply, signaling a new public health challenge.

26 Jun 2025