Lysosomes News and Research

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Discovery lays foundation for understanding how the cell senses membrane injuries

When the cell's recycling stations, the lysosomes, start leaking, it can become dangerous. Toxic waste risks spreading and damaging the cell.

12 Jan 2026

Dihydrotanshinone I induces autophagic cell death in ovarian cancer

A recent study published in Engineering has shed light on the potential therapeutic effects of dihydrotanshinone I (DHT), a compound derived from the traditional Chinese herb Salvia miltiorrhiza, on ovarian cancer.

30 Dec 2025

Scientists reverse aging in blood stem cells by restoring lysosome function

Researchers at the Icahn School of Medicine at Mount Sinai have discovered how to reverse aging in blood-forming stem cells in mice by correcting defects in the stem cell's lysosomes.

24 Nov 2025

Changes in brain fats play a key role in Alzheimer's development and progression

More than a century ago, Alois Alzheimer noted unusual changes in brain fats, which he described as "lipoid granules," along with the buildup of amyloid-beta (amyloid) plaques and tau protein tangles.

20 Nov 2025

New insights into how endoplasmic reticulum and lysosomes coordinate protein production

Janelia researchers have uncovered a novel way that two of the structures inside cells-the endoplasmic reticulum (ER) and lysosomes-coordinate the production of proteins, highlighting how interactions between organelles are important for regulating cellular processes.

11 Nov 2025

MIT researchers identify new vaccine targets to fight tuberculosis

A large-scale screen of tuberculosis proteins has revealed several possible antigens that could be developed as a new vaccine for TB, the world's deadliest infectious disease.

5 Nov 2025

Mitochondria and lysosomes work together to control regulatory T cell activation

Metabolism guides the activation states of regulatory T cells, the immune cells that prevent inappropriate activation of the immune system.

24 Oct 2025

Discovery of EUDAL reveals new mechanism behind chemotherapy resistance in oral cancer

Oral cancer is one of the most common head and neck cancers worldwide, with hundreds of thousands of new cases diagnosed every year. Despite advances in surgery, radiotherapy, and chemotherapy, survival rates remain poor.

30 Sep 2025

Lysosomal activity in worms linked to transgenerational extension of lifespan

In the Wang Lab, it's not unusual for worms to live for a long time. HHMI Janelia Research Campus Senior Group Leader Meng Wang and her team study longevity. They've shown that by overexpressing an enzyme in the lysosomes of the roundworm C. elegans, they can extend the worm's life by up to 60 percent.

25 Sep 2025

How food choices and cooking methods drive brain inflammation and disease

Researchers reviewing evidence in NeuroSci show how dietary AGEs and their interaction with RAGE drive oxidative stress, inflammation, and neurodegeneration. They highlight how cooking methods and diet choices could lower AGE burden and protect brain health, while calling for rigorous clinical trials.

24 Sep 2025

Lysosomal acidity fine-tunes reactive species production in macrophages

Macrophages rely on lysosomes to balance microbial killing with self-protection, generating reactive oxygen and nitrogen species during phagocytosis.

21 Sep 2025

High fat diet impairs memory formation through autophagy dysfunction

Modern lifestyles and dietary changes have significantly increased the consumption of high-fat foods, contributing to a steep rise in the prevalence of obesity, diabetes, and metabolic disorders.

17 Sep 2025

Targeting the lysosome-iron-mitochondria axis for osteoporosis therapy

Osteoporosis is a common skeletal disorder characterized by excessive bone loss, leading to increased fragility and an increased risk of fractures.

5 Sep 2025

Genetic variant disrupts brain’s cleanup crew increasing Alzheimer’s risk

A Nature study published today and led by researchers at the University of South Florida's USF Health Byrd Alzheimer's Institute pinpoints how a genetic variant disrupts microglia - the brain's "cleanup crew" - increasing the risk of Alzheimer's disease.

3 Sep 2025

Researchers discover a direct pathway for macrophage cleanup

Macrophages are part of the immune system's frontline; they attack and eat invaders to protect surrounding cells. They, along with other cells, maintain intracellular conditions through macroautophagy, using autophagosomes to help digest broken cell components.

2 Sep 2025

Cellular purging process may help injured cells revert to stem cell-like state more rapidly

Now, a new study in mice led by researchers at Washington University School of Medicine in St. Louis and the Baylor College of Medicine reveals a previously unknown cellular purging process that may help injured cells revert to a stem cell-like state more rapidly.

29 Aug 2025

Research shows how lysosomes respond to stress

New research, published today in the journal Science, shows how lysosomes - organelles that act like cells' waste disposal system - respond to stress by becoming abnormally bloated, a process called lysosomal vacuolation that is associated with numerous diseases.

21 Aug 2025

New pH-responsive nanomaterials enhance precision drug delivery to tumors

Cancer remains one of the leading causes of death worldwide, and despite advancements in diagnosis and treatment, it continues to impose a significant health burden globally.

7 Aug 2025

Targeted microglia replacement shows promise against fatal neurodegenerative conditions

Tay-Sachs and Sandhoff diseases, genetic disorders affecting the brain, have no effective treatment and are typically fatal within the first years of life.

6 Aug 2025

Human eggs use a minimalist strategy to stay healthy for decades

Human eggs are some of the most patient cells in the body, lying dormant for decades until needed. A study published today in The EMBO Journal shows that the cells deliberately slow the activity of their internal waste disposal systems as they mature, most likely an evolutionary design which keeps metabolism low and damage at bay.

18 Jul 2025