Melanoma Cells News and Research

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New light-activated technology enhances immune cells' ability to target solid tumors

Immunotherapies that mobilize a patient's own immune system to fight cancer have become a treatment pillar. These therapies, including CAR T-cell therapy, have performed well in cancers like leukemias and lymphomas, but the results have been less promising in solid tumors.

21 Oct 2024

Gene editing restores treatment sensitivity in melanoma

In a potential advance for melanoma patients, researchers at ChristianaCare’s Gene Editing Institute have used CRISPR gene editing tools to disable a gene mutation often seen in aggressive forms of this dangerous skin cancer that renders promising treatments ineffective.

16 Oct 2024

Age-related fibroblast changes in males drive aggressive melanoma

Age-related changes in the fibroblasts, cells that create the skin's structure, contribute to the development of aggressive, treatment-resistant melanoma in males, according to research in mice by the Johns Hopkins Kimmel Cancer Center.

6 Sep 2024

New insights on how melanoma cells resist cancer immunotherapy

Immune checkpoint inhibitors are cancer fighting drugs that help the immune system do its job of detecting and attacking tumor cells.

27 Aug 2024

Study provides novel insights into the molecular mechanisms of melanoma progression

Cong Peng et al., at Department of Dermatology, Xiangya Hospital, Central South University, China, conducted a study titled "NETO2 promotes melanoma progression via activation of the Ca²⁺/CaMKII signaling pathway" that investigates the role of Neuropilin and tolloid-like 2 (NETO2) in melanoma, a deadly form of skin cancer.

2 Aug 2024

Ethanolic extracts from olive leaves show promise in combating cancer and infections

A recent study in Antioxidants reveals that ethanolic extracts from Greek and Spanish olive leaves exhibit high antioxidant, antimicrobial, and anticancer properties, with Greek extracts showing greater efficacy. This suggests potential healthcare applications, particularly as antimicrobial agents and melanoma treatments.

30 Jun 2024

Study identifies mechanism that impedes the effectiveness of melanoma therapies

In many cases of malignant melanoma, the effect of targeted treatment is lost over time. A research team from UZH and USZ has now discovered that a factor secreted by tumor cells is responsible for the resistance.

27 Jun 2024

New Approach to Treating Melanoma

An international research team, led by Professor Wenbo Bu of Fudan University and Distinguished Professor Dayong Jin of the University of Technology Sydney, have discovered an innovative method to effectively treat cancer by reactivating suppressed metabolic pathways in cancer cells.

20 Jun 2024

New technique uses nutrients to effectively treat cancer

An international research team has discovered a new way to effectively treat cancer, by using nutrients to reactivate suppressed metabolic pathways in cancer cells.

17 Jun 2024

New therapeutic target discovered for treatment-resistant melanoma

An international research team led by scientists from the University of Liège (Belgium) has discovered an interesting new therapeutic target for the treatment of melanoma resistant to targeted therapies.

8 Jun 2024

Second-generation melanoma vaccine prolongs survival of patients with skin cancer

A second-generation melanoma vaccine being developed at UVA Cancer Center improves long-term survival for melanoma patients compared with the first-generation vaccine, new research shows.

29 Mar 2024

DNA origami vaccine DoriVac paves way for personalized cancer immunotherapy

Therapeutic cancer vaccines are a form of immunotherapy in the making that could not only destroy cancer cells in patients, but keep a cancer from coming back and spreading.

15 Mar 2024

Innovative immunotherapy targets rare melanoma subtypes

Scientists at the UCLA Health Jonsson Comprehensive Cancer Center have built and demonstrated the potential efficacy of a new chimeric antigen receptor (CAR) T-cell-based immunotherapy specifically designed to treat patients with cutaneous and rare subtypes of melanoma.

16 Feb 2024

Androgen receptor signaling found to upregulate gene driving melanoma severity in men

Method by which androgen-activated androgen receptors (ARs) increase fucosyltransferase 4 (FUT4) expression.

12 Feb 2024

Research upends understanding of circadian clock in melanoma

A Ludwig Cancer Research study has found that the circadian clock - which synchronizes physiological and cellular activities with the day-night cycle and is generally thought to be tumor suppressive - in fact has a contextually variable role in cancer.

27 Jan 2024

Study uncovers cell signaling pathway that regulates melanoma brain metastasis

Melanoma is the deadliest form of skin cancer because of its ability to quickly grow and spread throughout the body.

29 Nov 2023

Researchers identify biomarkers for checkpoint inhibitor-induced hyperprogression of melanoma cells

Duke Cancer Institute researchers have identified potential biomarkers that predict the likelihood for checkpoint inhibitor drugs to backfire, driving hyper-progression of melanoma cells instead of unleashing the immune system to fight them.

24 Nov 2023

Researchers discover new option to target the metastatic capacity of melanoma cells

As an extremely aggressive form of skin cancer, cutaneous melanoma is still associated with a high mortality rate. Enormous progress has recently been made in the fight against deadly metastasis, but existing therapeutic measures are still not effective in many cases.

21 Nov 2023

HMS immunologist unravels the mysteries of how the immune system communicates

The immune system is a crucial part of our survival, regularly fending off wide-ranging attacks on the body, both internal and external.

9 Nov 2023

Unveiling hidden threats: clustering loops in CAR-T cells impact cancer therapy

How complementarity-determining region (CDR) loops in the single-chain variable fragment (scFv) influence chimeric antigen receptor (CAR)-T cell behavior.

14 Aug 2023