Nephrology News and Research

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Nephrology is a branch of internal medicine and pediatrics dealing with the study of the function and diseases of the kidney.

Scientists discover why patients with chronic kidney disease die of heart problems

Scientists have discovered an answer to the longstanding mystery of why more than half of patients with chronic kidney disease ultimately die of cardiovascular problems: Their kidneys produce a substance that poisons the heart.

20 Jan 2026

A single immune protein may help explain why kidney and heart disease often develop together

This review synthesizes clinical, genetic, and mechanistic evidence showing that suPAR and related uPAR fragments are strongly associated with kidney, cardiovascular, and metabolic disease risk. It highlights suPAR as a stable biomarker of innate immune activation with potential pathogenic roles, while underscoring major gaps in assay standardization and therapeutic validation.

6 Jan 2026

New atomic structure reveals how NBCn1 transporter protein aids breast cancer cell survival

UCLA scientists have characterized the structure and function of a key survival protein in breast cancer cells that helps explain how these tumors resist environmental stress and thrive in acidic, low-oxygen environments that would normally be toxic to healthy cells.

5 Dec 2025

Study provides first molecular evidence that ferroptosis can drive neurodegeneration

Researchers at Helmholtz Munich, the Technical University of Munich and the LMU University Hospital Munich uncovered a mechanism that protects nerve cells from premature cell death, known as ferroptosis.

4 Dec 2025

Chronic kidney disease accelerates cognitive decline through heart-brain pathways

A new study published in the American Journal of Physiology - Heart and Circulatory Physiology reveals that chronic kidney disease (CKD) accelerates cognitive decline through interconnected damage to the heart and brain-and that these pathways differ markedly between men and women.

4 Dec 2025

Culturally tailored intervention helps reduce interdialytic weight gain in kidney failure care

The intervention, called Navigate-Kidney, utilizes community health workers (CHWs) to help patients undergoing hemodialysis understand and work through challenges that come with treatment, including socioeconomic factors, particularly food insecurity as well as lack of culturally responsive care, and disparities in access to health insurance and health care.

24 Nov 2025

Study reveals the long-lasting health impacts of eating disorders

The health impacts of eating disorders, such as anorexia, bulimia, and binge eating, are not only complex, affecting many different organ systems, but long-lasting, finds a large tracking study, published in the open access journal BMJ Medicine.

19 Nov 2025

Revised ESE clinical guideline published for the management of hypoparathyroidism in adults

The European Society of Endocrinology (ESE) has published an open access Revised Clinical Practice Guideline for the Treatment of Chronic Hypoparathyroidism in Adults in the European Journal of Endocrinology, Volume 193, Issue 5, November 2025.

13 Nov 2025

New approach to kidney transplant listing could improve outcomes and equity

The current kidney transplant waitlisting criterion is based on a single measurement of kidney function (estimated glomerular filtration rate [eGFR] ≤20 ml/min/1.73m2) and does not consider an individual's risk of progressing to kidney failure.

13 Nov 2025

Texas' transitional dialysis program led to significant decline in utilization of emergency dialysis

The cost of emergency dialysis is estimated to be 8-times that of in-center dialysis. A new study reveals that a transitional dialysis program piloted in Travis County (Austin, TX) resulted in a significant decrease in emergency department visits and hospital admissions for emergency dialysis by providing a pathway for outpatient dialysis in uninsured patients.

10 Nov 2025

Expanding the waitlisting criteria for kidney transplantation could improve patient outcomes

The current kidney transplant waitlistingcriterion is based on a single measurement of kidney function (estimated glomerular filtration rate [eGFR] ≤20 ml/min/1.73m2) and does not consider an individual’s risk of progressing to kidney failure.

10 Nov 2025

New protocol developed for diagnosis and treatment of metformin-associated lactic acidosis

Metformin-associated lactic acidosis (MALA) is a rare but serious adverse effect of the diabetes drug metformin in which the body accumulates too much lactic acid. Investigators developed and tested a protocol for diagnosis and treatment of MALA.

10 Nov 2025

Using estimated risks and preferences to justify intensive BP control in CKD patients

An analysis of the Systolic Blood Pressure Intervention Trial (SPRINT) indicates that nearly all adults with chronic kidney disease (CKD) would have benefits that outweigh the harm from a systolic blood pressure target of <120 mm Hg compared with a target of <140 mm Hg. The findings will be presented at ASN Kidney Week 2025 November 5– 9.

8 Nov 2025

Preclinical evidence supports sotagliflozin's superior efficacy in attenuating salt-induced kidney damage

Sodium-glucose co-transporter 2 (SGLT2) inhibitors, initially developed to treat type 2 diabetes, have significant heart- and kidney- protective effects. In the kidney, SGLT2 reabsorbs approximately 97% offiltered glucose in the S1 and S2 segments of the proximal tubule, while SGLT1reabsorbs the remainder in the S3 segment.

8 Nov 2025

Study shows record surge in reduced kidney function worldwide

Record numbers of men and women globally are now estimated to have reduced kidney function, a new study shows. Figures rose from 378 million people with the disease in 1990 to 788 million in 2023 as the world population grew and aged, making it for the first time a top 10 cause of death worldwide.

8 Nov 2025

SGLT2 inhibitors show consistent cardio-renal protection in 70,000 patients

In late-breaking presentations at the American Society of Nephrology Kidney Week meeting and simultaneously published in two companion papers in JAMA, the findings are based on data from over 70,000 participants across 10 major randomised controlled trials. The meta-analyses were conducted by the SGLT2 Inhibitor Meta-analysis Cardio-Renal Trialists' Consortium (SMART-C), led by The George Institute for Global Health.

7 Nov 2025

Pediatric patients with primary glomerular diseases may experience faster kidney function decline

New research reveals that contrary toconventional belief, primary glomerular diseases are not necessarily benign for children and young adults. In fact, some subsets of children and young adults may experience faster kidney function decline than older patients.

7 Nov 2025

Nephrology News and Research

Further Reading

Scientists discover why patients with chronic kidney disease die of heart problems

A single immune protein may help explain why kidney and heart disease often develop together

New atomic structure reveals how NBCn1 transporter protein aids breast cancer cell survival

Study provides first molecular evidence that ferroptosis can drive neurodegeneration

Chronic kidney disease accelerates cognitive decline through heart-brain pathways

Culturally tailored intervention helps reduce interdialytic weight gain in kidney failure care

Study reveals the long-lasting health impacts of eating disorders

Revised ESE clinical guideline published for the management of hypoparathyroidism in adults

New approach to kidney transplant listing could improve outcomes and equity

Texas' transitional dialysis program led to significant decline in utilization of emergency dialysis

Expanding the waitlisting criteria for kidney transplantation could improve patient outcomes

New protocol developed for diagnosis and treatment of metformin-associated lactic acidosis

Using estimated risks and preferences to justify intensive BP control in CKD patients

Preclinical evidence supports sotagliflozin's superior efficacy in attenuating salt-induced kidney damage

Study shows record surge in reduced kidney function worldwide

SGLT2 inhibitors show consistent cardio-renal protection in 70,000 patients

Pediatric patients with primary glomerular diseases may experience faster kidney function decline

Mismatch in kidney tests may reveal hidden health risks

Study reveals structural and cellular clues behind cancer-linked GnT-V enzyme selectivity

Finerenone offers hope for kidney protection in patients with type 1 diabetes

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