Nephrology News and Research

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Nephrology is a branch of internal medicine and pediatrics dealing with the study of the function and diseases of the kidney.

Preclinical evidence supports sotagliflozin's superior efficacy in attenuating salt-induced kidney damage

Sodium-glucose co-transporter 2 (SGLT2) inhibitors, initially developed to treat type 2 diabetes, have significant heart- and kidney- protective effects. In the kidney, SGLT2 reabsorbs approximately 97% offiltered glucose in the S1 and S2 segments of the proximal tubule, while SGLT1reabsorbs the remainder in the S3 segment.

8 Nov 2025

Study shows record surge in reduced kidney function worldwide

Record numbers of men and women globally are now estimated to have reduced kidney function, a new study shows. Figures rose from 378 million people with the disease in 1990 to 788 million in 2023 as the world population grew and aged, making it for the first time a top 10 cause of death worldwide.

8 Nov 2025

SGLT2 inhibitors show consistent cardio-renal protection in 70,000 patients

In late-breaking presentations at the American Society of Nephrology Kidney Week meeting and simultaneously published in two companion papers in JAMA, the findings are based on data from over 70,000 participants across 10 major randomised controlled trials. The meta-analyses were conducted by the SGLT2 Inhibitor Meta-analysis Cardio-Renal Trialists' Consortium (SMART-C), led by The George Institute for Global Health.

7 Nov 2025

Pediatric patients with primary glomerular diseases may experience faster kidney function decline

New research reveals that contrary toconventional belief, primary glomerular diseases are not necessarily benign for children and young adults. In fact, some subsets of children and young adults may experience faster kidney function decline than older patients.

7 Nov 2025

Mismatch in kidney tests may reveal hidden health risks

A mismatch between two common tests for kidney function may indicate a higher risk for kidney failure, heart disease, and death, a new study shows.

7 Nov 2025

Study reveals structural and cellular clues behind cancer-linked GnT-V enzyme selectivity

Glycans are important complex carbohydrates found on cell surfaces that serve crucial roles in cell-to-cell communication, structure, and protection.

7 Nov 2025

Finerenone offers hope for kidney protection in patients with type 1 diabetes

The drug finerenone has a positive effect on patients with type 1 diabetes and chronic kidney disease.

6 Nov 2025

A parent's guide to manage pediatric respiratory illnesses during the virus season

As we head deeper into fall and toward the holiday season, your little one may start to exhibit symptoms like a runny nose, cough, or fever.

24 Oct 2025

Novel molecule found to be a key player in kidney injury and repair

Chronic kidney disease (CKD) is a progressive condition in which the kidneys gradually lose their ability to filter waste from the blood.

23 Oct 2025

Shift workers face higher risk of developing kidney stones

A study evaluating how various shift work patterns contribute to kidney stone risk has revealed that shift workers have a 15% higher risk of developing kidney stones, especially younger workers and those with low levels of manual labor.

2 Oct 2025

Microplastics pose potential risks to bone health

The production and use of over 400 million tons of plastic each year has polluted beaches, rivers, and even the deepest parts of the ocean, reaching depths of up to 11,000 meters.

18 Sep 2025

Lymphatic vessels found to undergo dramatic changes during kidney transplant rejection

Scientists have uncovered how lymphatic vessels – the kidney's 'plumbing system' – undergo dramatic changes during chronic transplant rejection, becoming structurally disorganised and spreading to unusual parts of the kidney.

16 Sep 2025

New class of antihypertensive medications may have both kidney- and cardio-protective benefits

Adding the novel medication baxdrostat to standard care may help manage high blood pressure and delay the progression of kidney disease in people with chronic kidney disease and uncontrolled high blood pressure , according to preliminary research presented at the American Heart Association's Hypertension Scientific Sessions 2025.

8 Sep 2025

Estrogen supports kidney regeneration and protects women from chronic disease

A new study in mice provides insights into why females in their reproductive years appear to be relatively protected from chronic kidney disease, a leading public health concern.

4 Sep 2025

New ESC guidelines introduce unified approach to improve myocarditis and pericarditis care

New ESC Guidelines to improve the diagnosis and care of patients with myocarditis and pericarditis, have been published today at ESC Congress 2025.

30 Aug 2025

Glycosylation emerges as a key player in kidney disease progression

Kidney diseases affect nearly 700 million people worldwide and are a growing cause of mortality and health care costs.

29 Aug 2025

Somatic mutations drive vascular aging and muscle weakness over time

Two new studies from Karolinska Institutet in Sweden have investigated how mutations that occur in muscles and blood vessels over time can affect aging.

20 Aug 2025

Improving gene therapy safety with human kidney organoids

Ryuji Morizane, MD, PhD, of the Department of Medicine at Massachusetts General Hospital, is the senior/corresponding author of a new paper published in Signal Transduction and Targeted Therapy, "AAV for gene therapy drives a nephrotoxic response via NFκB in kidney organoids."

19 Aug 2025

Study identifies biomarkers that could help predict and manage chronic kidney disease

Biomarkers that could help predict and manage chronic kidney disease (CKD) have been identified in a new study led by the University of Surrey.

12 Aug 2025

Early treatment withdrawal offers safety and savings for patients with rare kidney disease

Early withdrawal of a treatment for patients with a rare kidney disease is possible without relapse, safer for patients and saves the NHS millions of pounds, new research has revealed.

7 Aug 2025

Nephrology News and Research

Further Reading

Preclinical evidence supports sotagliflozin's superior efficacy in attenuating salt-induced kidney damage

Study shows record surge in reduced kidney function worldwide

SGLT2 inhibitors show consistent cardio-renal protection in 70,000 patients

Pediatric patients with primary glomerular diseases may experience faster kidney function decline

Mismatch in kidney tests may reveal hidden health risks

Study reveals structural and cellular clues behind cancer-linked GnT-V enzyme selectivity

Finerenone offers hope for kidney protection in patients with type 1 diabetes

A parent's guide to manage pediatric respiratory illnesses during the virus season

Novel molecule found to be a key player in kidney injury and repair

Shift workers face higher risk of developing kidney stones

Microplastics pose potential risks to bone health

Lymphatic vessels found to undergo dramatic changes during kidney transplant rejection

New class of antihypertensive medications may have both kidney- and cardio-protective benefits

Estrogen supports kidney regeneration and protects women from chronic disease

New ESC guidelines introduce unified approach to improve myocarditis and pericarditis care

Glycosylation emerges as a key player in kidney disease progression

Somatic mutations drive vascular aging and muscle weakness over time

Improving gene therapy safety with human kidney organoids

Study identifies biomarkers that could help predict and manage chronic kidney disease

Early treatment withdrawal offers safety and savings for patients with rare kidney disease

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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