Neuro oncology News and Research

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Disrupted brainstem-parahippocampal connectivity identified as a biomarker for delirium

Delirium, commonly observed in critically ill patients following intracerebral hemorrhage (ICH), is an acute neuropsychiatric disorder characterized by disturbances in attention, consciousness, and cognition.

31 Oct 2025

Immune cell dysregulation and inflammatory mediators shape epilepsy risk

Emerging evidence implicates immune dysregulation and neuroinflammation in the pathogenesis of epilepsy, yet the causal mechanisms remain unclear.

31 Oct 2025

Innovative system accurately detects genetic mutations in the brain tumor within 25 minutes

A research team in Japan has developed an innovative system that can accurately detect genetic mutations in the brain tumor within just 25 minutes.

9 Oct 2025

Moffitt awarded $22.4 million grant to lead novel studies and clinical trials for leptomeningeal disease

Researchers at Moffitt Cancer Center have been awarded a $22.4 million grant from the U.S. Department of War to lead groundbreaking studies and clinical trials for leptomeningeal disease, a devastating complication of breast and other cancers that spreads to the coverings of the brain and spinal cord.

6 Oct 2025

Early trial finds promise for avelumab and radiation in treating leptomeningeal disease

Researchers at Moffitt Cancer Center have reported encouraging results from a phase 1B clinical trial showing that the immunotherapy drug avelumab, when combined with whole brain radiotherapy, may provide a safe and effective treatment option for patients with leptomeningeal disease, one of the most aggressive and difficult-to-treat complications of advanced cancer.

30 Sep 2025

AI tool accurately distinguishes between glioblastoma and primary central nervous system lymphoma

A Harvard Medical School–led research team has developed an AI tool that can reliably tell apart two look-alike cancers found in the brain but with different origins, behaviors, and treatments.

29 Sep 2025

New nomogram offers personalized prognosis for brain abscess survival

Despite improvements in medical and surgical management strategies, brain abscess continues to cause disability and mortality in affected individuals.

20 Aug 2025

AI technology advances early detection of glioblastoma progression

University of Virginia School of Medicine scientists are tapping the power of artificial intelligence to enhance and accelerate treatment for glioblastoma, the deadliest brain cancer.

7 Aug 2025

New research provides the first clinically relevant overview of childhood brain tumors

Childhood brain tumor survival depends on the type of tumor. Comparing survival rates across countries is difficult, because brain tumors aren't recorded in the same way everywhere in Europe. A new study led by the Princess Máxima Center is helping to change that. For the first time, the research provides a clear and clinically relevant overview of survival outcomes for children with brain tumors.

29 Jul 2025

Researchers honored for groundbreaking work in cancer neuroscience

The University of Virginia School of Medicine's Harald Sontheimer, PhD, and Stanford's Michelle Monje, MD, PhD, have received the 2025 International Prize in Translational Neuroscience from the Gertrud Reemtsma Foundation for their pioneering research in the emerging field of cancer neuroscience.

18 Jul 2025

Gamma knife radiosurgery shows high tumor control in brain metastases from ovarian cancer

Brain metastases from ovarian cancer (BMFOC) are rare but associated with poor prognosis. This study aimed to evaluate the efficacy and safety of Gamma Knife stereotactic radiosurgery (GKSRS) in managing patients with BMFOC.

8 Jul 2025

Uncommitted cells offer clues to neuroblastoma regression

Neuroblastoma is a cancer that affects the sympathetic nervous system of children. It is unusual among cancers because it shows a range of outcomes: from aggressive, potentially fatal progression to a unique phenomenon where the tumor spontaneously regresses even without treatment.

25 Jun 2025

Glioblastoma patients live longer with triple treatment strategy

A new study led by Keck Medicine of USC researchers may have uncovered an effective combination therapy for glioblastoma, a brain tumor diagnosis with few available effective treatments.

9 Jun 2025

Dual-target CAR T cell therapy shrinks tumors in aggressive brain cancer

A dual-target CAR T cell therapy approach shows promise for slowing tumor growth in a notoriously aggressive and fast-growing brain cancer.

1 Jun 2025

New genetic test speeds up brain tumor diagnosis to just two hours

Scientists and medics have developed an ultra-rapid method of genetically diagnosing brain tumors that will cut the time it takes to classify them from 6-8 weeks, to as little as two hours – which could improve care for thousands of patients each year in the UK.

21 May 2025

CAR-T cell therapy linked to brain fog in cancer patients

After treatment with CAR-T cells - immune cells engineered to attack cancer - patients sometimes tell their doctors they feel like they have "brain fog," or forgetfulness and difficulty concentrating.

12 May 2025

Study evaluates long-term outcomes of gamma knife radiosurgery in patients with grade 2 meningiomas

The role of radiosurgery in the treatment of grade 2 meningioma remains unclear. This study aimed to evaluate the long-term outcomes of gamma knife radiosurgery (GKRS) in patients with grade 2 meningiomas and to identify factors influencing tumor control and survival.

28 Apr 2025

Promising results seen in atypical trigeminal neuralgia with combined surgical approach

Atypical trigeminal neuralgia (ATN) is a chronic pain condition characterized by persistent facial pain that does not respond well to conventional medical treatments, often leading to significant impairment in quality of life.

25 Apr 2025

Study reveals how medulloblastoma spreads and grows on the leptomeninges

Researchers at Baylor College of Medicine, Texas Children's Hospital, the Hospital for Sick Children in Toronto and collaborating institutions reveal in Nature Cell Biology a strategy that helps medulloblastoma, the most prevalent malignant brain tumor in children, spread and grow on the leptomeninges, the membranes surrounding the brain and spinal cord.

22 Apr 2025

FOXR2 activation found in multiple pediatric brain tumor types

Physicians classify brain tumors and determine treatment options, in part, by the genes they express. According to World Health Organization standards, the abnormal activation of oncogene FOXR2 only occurs in central nervous system (CNS) neuroblastoma, but that may not be true.

16 Apr 2025