Plasmid News and Research

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Electromagnetic waves disrupt SARS-CoV-2 spike protein and lower infectivity

Researchers demonstrated that specific electromagnetic wave frequencies can disrupt the SARS-CoV-2 Spike protein structure in virus-like particles, leading to reduced infectivity in cell models. This proof-of-concept study suggests new avenues for non-chemical viral inactivation methods.

18 May 2025

Air travel disrupts DNA repair in flight crew, raising cancer concerns

Researchers found that flight attendants show reduced DNA repair capacity and immune changes after air travel, which may help explain their higher cancer risk.

14 May 2025

Scientists build world's most accessible gut bacteria collection to unlock health and disease clues

Researchers have developed the Human Intestinal Bacteria Collection (HiBC), comprising 340 gut bacterial strains from 198 species, including 29 newly described taxa, made publicly available for functional microbiome research.

7 May 2025

HO-1 regulates liver fibrosis in NAFLD through the SIRT1 TGF-β Smad3 pathway

Heme oxygenase 1 (HO-1) has an influential yet insufficiently investigated effect on Sirtuin 1 (SIRT1), a histone deacetylase activated by nicotinamide adenine dinucleotide, which may impact the transforming growth factor-β (TGF-ß)/Smad3 pathway in nonalcoholic fatty liver disease (NAFLD)-related liver fibrosis.

2 May 2025

Research offers new hope in the fight against antibiotic-resistant bacteria

Antibiotic resistance is a serious threat to public health. When antibiotics don't work, we risk not being able to treat many types of infections and people who would previously have been cured, can die.

23 Apr 2025

New bacterial evolutionary map could lead to precision treatments for infections

The first-of-its-kind in-depth bacterial evolutionary map could pave the way for the development of precision treatments for certain antibiotic-resistant infections, such as urinary tract infections.

3 Apr 2025

4basebio receives MHRA GMP licence for manufacture and supply of synthetic DNA

4basebio PLC (“4basebio”), a company which develops and commercializes the large-scale manufacture of synthetic DNA as well as nanoparticle delivery solutions, today announced that it has received Good Manufacturing Practice (GMP) certification from the UK’s Medicines and Healthcare products Regulatory Agency (MHRA).

From 4basebio PLC 3 Apr 2025

New RNA barcoding method tracks gene transfer in microbial communities

In the microscopic world of bacteria, gene transfer is a powerful mechanism that can alter cellular function, drive antibiotic resistance and even shape entire ecosystems.

19 Mar 2025

MRNA vaccines, once a Trump boast, now face attacks from some in GOP

Researchers racing to develop bird flu vaccines for humans have turned to a cutting-edge technology that enabled the rapid development of lifesaving covid shots.

10 Mar 2025

Exosome-mediated siRNA delivery targets antibiotic resistance in bacteria

Multidrug-resistant bacteria pose a major threat to human health. Manipulation of bacterial genes at the transcriptional level is a potential strategy to fight antibiotic-resistant bacterial infections by silencing their resistance genes.

7 Mar 2025

Schrödinger selects Sapio Sciences to enhance in silico drug discovery from plasmid to structure

Sapio Sciences, the science-aware™ lab informatics platform, today announced that Schrödinger, a global leader in computational chemistry, has adopted the Sapio Platform to improve data management, enhance lab efficiency, and accelerate the discovery of novel molecules.

From Sapio Sciences 29 Jan 2025

New discovery sheds light on how bacteria use plasmids to build resistance

An international collaboration has achieved an important breakthrough in understanding the genetic mechanisms that allow bacteria to build resistance to drugs.

23 Jan 2025

Gene therapy to prevent stillbirth and premature delivery developed

Researchers investigate the effectiveness of placental nano-based insulin-like 1 growth factor gene therapy to correct fetal growth restriction.

12 Dec 2024

Prostate cancer vaccines: Progress, challenges, and future directions

Prostate cancer vaccines, including dendritic and peptide types, offer hope for improved treatments, but face hurdles in clinical effectiveness and validation.

11 Dec 2024

Dietary zinc may reduce plasmid transfer in gut microbes

Genes responsible for antimicrobial resistance (AMR) can spread from microbe to microbe through circular genetic material called plasmids, and this lateral transfer occurs in the gut.

3 Oct 2024

Study reveals genetic elements driving Klebsiella pneumoniae hypervirulence

More than a decade ago, physicians around the world began reporting cases due to a new hypervirulent strain of Klebsiella pneumoniae, which could infect and severely sicken otherwise healthy people.

1 Oct 2024

Asimov launches AAV Edge, a suite of AI models, host cells, and genetic tools for end-to-end gene therapy development

Asimov, the synthetic biology company advancing the design and production of therapeutics, today announced the launch of the AAV Edge System, a comprehensive suite of tools for adeno-associated viral (AAV) gene therapy design and manufacturing.

18 Sep 2024

New bacterial defense mechanism revealed as potential tool for genome editing

Scientists who have described in a new study the step-by-step details of a bacterial defense strategy see the mechanism as a promising platform for development of a new genome-editing method.

29 Aug 2024