Dysplasia News and Research

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Dysplasia is a term used in pathology to refer to an abnormality in maturation of cells within a tissue. This generally consists of an expansion of immature cells, with a corresponding decrease in the number and location of mature cells.

Estrogen activates critical lung genes to improve lung function following preterm birth

Estrogen may be a new postnatal therapy to improve lung function and other outcomes in preterm infants, researchers at UT Southwestern Medical Center have found in an animal study.

12 Mar 2009

Estrogen may be a new postnatal therapy to improve lung function and other outcomes in preterm infants

"Ironically, a hormone that has received great attention as a potential means to optimize the health of older women may be a beneficial treatment for humans during the earliest stages of life," said Dr. Philip Shaul, professor of pediatrics at UT Southwestern and the study's senior author.

12 Mar 2009

Difluoromethylornithine may affect Barrett's esophagus

"While there was a suggestion that difluoromethylornithine (DFMO) may influence the extent of Barrett's dysplasia, this finding is very preliminary and further study of this agent in a larger number of patients is needed," said Frank A. Sinicrope, M.D., professor of medicine and oncology at the Mayo Clinic, Rochester, MN.

16 Nov 2008

Adalimumab therapy may reduce health-care costs for Crohn's disease patients

Inflammatory bowel disease (IBD) is a term that refers to both ulcerative colitis (UC) and Crohn's disease (CD).

12 Nov 2008

Discovery of biomarkers for esophageal cancer before it develops

Rhode Island Hospital researchers have identified genetic proteins, also known as biomarkers, capable of distinguishing changes at the microscopic level that can signal a precancerous condition in the esophagus.

4 Nov 2008

Sports-related sudden cardiac death is reduced by pre-participation cardiovascular screening

Young competitive athletes are perceived by the general population to be the healthiest members of society. The possibility that highly trained athletes may have a potentially serious cardiac condition that can predispose to life-threatening tachyarrhythmias or sudden cardiac death seems paradoxical.

31 Aug 2008

New therapy freezes out esophagus cancer

UT Southwestern Medical Center gastroenterologists are using a new method to freeze damaged cells in the esophagus, preventing them from turning cancerous.

29 Jul 2008

Less invasive approach for the treatment of cervical intraepithelial neoplasia

In the United States alone, approximately three-and-a-half million women have abnormal Pap smear tests each year.

23 Jun 2008

Oxygen-rich lifesaving efforts pose risk for respiratory infections

Each year, thousands of premature infants battle to breathe. Thanks to life-saving interventions developed in the past couple decades - steroids given to their mothers to stall pre-term labor, mechanical ventilation, air enriched with extra oxygen, and surfactant, a crucial wetting agent that makes breathing less work - most of these newborns survive with enough lung function to grow and go home.

11 Jun 2008

Radiofrequency ablation is an effective treatment for dysplasia in people with Barrett's esophagus

Interim results from a nationwide clinical trial led by a University of North Carolina at Chapel Hill researcher suggest that radiofrequency ablation is an effective treatment for dysplasia in people with Barrett's esophagus, a condition that can lead to deadly gastrointestinal cancer.

19 May 2008

New laser treatment for vocal-cord cancer

An innovative laser treatment for early vocal-cord cancer, developed at Massachusetts General Hospital (MGH), successfully restores patients' voices without radiotherapy or traditional surgery, which can permanently damage vocal quality.

6 May 2008

Whole-organ genomic survey depicts journey from normal to malignant cell

Whole-organ maps that superimpose genetic information over the terrain of cancerous bladders chart the molecular journey from normal cell to invasive cancer, an international research team led by scientists at The University of Texas M. D. Anderson Cancer Center reports online at the journal Laboratory Investigation.

5 May 2008

New imaging technique provides better view of Barrett's esophagus

Novel techniques to improve the quality of imaging are helping doctors get a better look at esophageal conditions such as Barrett's esophagus (BE), but they do not necessarily improve the diagnosis or physician agreement on images, according to a study published this month in Gastroenterology , the official journal of the American Gastroenterological Association (AGA) Institute.

12 Mar 2008

Notch protein plays a critical role in bone formation

Notch, a protein known to govern the determination of cell differentiation into different kinds of tissues in embryos, plays a critical role in bone formation and strength later in life, said researchers from Baylor College of Medicine in Houston in a report that appears online today in the journal Nature Medicine.

26 Feb 2008

Genital mycoplasmas are a frequent cause of congenital fetal infection

Premature babies are subject to a host of threats that can result in fetal/neonatal disease.

7 Jan 2008

Narrow band imaging colonoscopy identifies flat dysplastic lesions in ulcerative colitis patients

A pilot study from researchers at Kyushu University in Fukuoka, Japan, found that narrow band imaging (NBI) colonoscopy used in cancer surveillance for ulcerative colitis patients can identify flat dysplastic lesions.

19 Nov 2007

Women still face cancer risk 25 years after treatment

Women are still at risk of developing invasive cancer of the cervix or vagina 25 years after being treated for pre-cancerous lesions, according to a study published today on bmj.com.

25 Oct 2007

First colonoscopy with removal of polyps linked to reduction in colon cancer death

Using a model to predict reductions in death from colorectal cancer, epidemiologists and clinical researchers from Memorial Sloan-Kettering looked at the relative effect of an initial screening colonoscopy which clears pre-cancerous polyps from the colon versus surveillance follow-up colonoscopy.

16 Oct 2007

Paving the way for future pan-European clinical trials

Pan-European collaboration is important for many clinical trials and essential for trials that are investigating treatments for rare diseases.

10 Oct 2007

Gene-chip studies provide new leads in treating abnormal lung development in premature newborns

Some 20 to 40 percent of extremely premature infants suffer abnormal lung development leading to bronchopulmonary dysplasia, a chronic lung disease that can cause long-term breathing problems.

4 Oct 2007