Metabolites News and Research

RSS

Ketone body β-hydroxybutyrate restores protein balance and targets Alzheimer’s-linked aggregates

Scientists identify β-hydroxybutyrate as a key regulator of protein solubility, offering a novel pathway to combat neurodegeneration in aging and Alzheimer’s disease.

4 Dec 2024

Scientists uncover coffee's surprising effect on gut microbiota

Scientists reveal that coffee consumption influences gut microbiota composition, with a strong link to the bacterium Lawsonibacter asaccharolyticus, independent of caffeine.

3 Dec 2024

Ketone metabolism redefines protein quality control in aging brains

Ketone bodies, produced by the body to provide fuel during fasting, have roles in regulating cellular processes and aging mechanisms beyond energy production. Research at the Buck Institute shows that ketone bodies can best be understood as powerful signaling metabolites affecting brain function in aging and Alzheimer's disease.

3 Dec 2024

Gut transit time and pH shape microbiome individuality and dietary responses

Scientists reveal gut transit time and pH as key drivers of microbiome and metabolic individuality, paving the way for personalized dietary strategies.

1 Dec 2024

Innovative annatto-based therapy shows promise for treating pediatric halitosis

A study by researchers working in Brazil shows that antimicrobial photodynamic therapy in which blue light targets annatto colorant is a feasible and effective option for treatment of halitosis in mouth-breathing children.

27 Nov 2024

MR1 molecule and vitamin B6 could unlock new paths for cancer immunotherapy

Effective immunity hinges on the ability to sense infection and cellular transformation. In humans, there is a specialized molecule on the surface of cells termed MR1.

27 Nov 2024

Study reveals how liver bile composition changes during enteric infections

Intestinal infections can change the composition of liver bile, leading to changes in immune function and gut bacteria, potentially helping fight off harmful bacteria .

26 Nov 2024

How neural and hormonal gut-brain communication shapes metabolism and health

Interoception research reveals how gut-brain communication via neural, hormonal, and microbial pathways regulates metabolism, hunger, and overall health, offering insights for therapeutic innovations.

25 Nov 2024

New technology enables rapid detection of TNT metabolites in the human body

Recently, a research group led by Prof. HUANG Chaoqun from the Hefei lnstitutes of Physical Science of the Chinese Academy of Sciences, developed an innovative dual drift tube ion mobility spectrometry (DDT-IMS) technology.

22 Nov 2024

Small brain-penetrating molecule offers hope for treating aggressive brain tumors

Gliocidin selectively kills glioblastoma cells by inhibiting nucleotide synthesis, showing potential as a therapeutic option in combination with temozolomide.

21 Nov 2024

How alcohol impacts male health

This research explores how alcohol consumption disrupts metabolism, damages the liver, and impairs male reproductive health, emphasizing the complex mechanisms and public health implications.

18 Nov 2024

Green tea kombucha could transform your gut and boost your weight-loss journey

Green tea kombucha improves gastrointestinal symptoms and alters the serum metabolome in individuals with excess body weight on an energy-restricted diet, showing potential metabolic health benefits.

18 Nov 2024

How vitamin B3 could be the secret to living longer and protecting your heart

Dietary niacin intake reduces risks of all-cause and cardiovascular mortality in US adults, with benefits more pronounced in non-diabetic individuals and linked to NAD metabolism improvements.

18 Nov 2024

Researchers use cerebrospinal fluid to unlock pathways in Alzheimer's disease

A multitude of genes have been linked to the development of Alzheimer's disease. Specifically how those genes might influence the progression of neurodegeneration remains something of a black box though, in part because of the challenges of examining in molecular detail the brain of a living patient.

14 Nov 2024

Healthy low-carb diet and time-restricted eating improve weight loss and gut health beyond calorie restriction

Researchers discovered that a healthy low-carb diet and time-restricted eating, combined with moderate calorie restriction, offer significant weight loss and gut health benefits for overweight adults, with some effects lasting up to 28 weeks post-intervention.

13 Nov 2024

Utilizing process Raman in optimizing cultivated meat production

Learn about the usage of process raman spectroscopy in the optimization of bioreactor monitoring and then improvement of cultivated meat production.

From Thermo Fisher Scientific – Pharmaceutical and Biopharmaceutical Solutions 13 Nov 2024

Novel compound BHB-Phe could offer new approach to weight loss

Researchers at Baylor College of Medicine, Stanford University School of Medicine and collaborating institutions report in the journal Cell the discovery of BHB-Phe, a novel compound produced by the body that regulates appetite and body weight through interactions with neurons in the brain.

12 Nov 2024

Studies link gut dysbiosis to pancreatic cancer, offering pathways for early detection

The gut microbiome's impact on pancreatic cancer highlights potential for early screening and fecal microbiota transplantation in improving treatment efficacy.

11 Nov 2024

New approach reinvigorates exhausted T cells to improve tumor control

As cancer cells grow, they pump out metabolic byproducts such as lactic acid into the tumor microenvironment. Exhausted T cells - which have lost their cancer-fighting oomph - consume this lactic acid, which further saps their energy, according to new research from the University of Pittsburgh and UPMC Hillman Cancer Center.

8 Nov 2024

Understanding metabolic alterations and immune dysfunction in acute-on-chronic liver failure

Acute-on-chronic liver failure (ACLF) is a life-threatening condition characterized by acute deterioration of liver function in patients with pre-existing chronic liver disease.

8 Nov 2024