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Terahertz imaging reveals cochlear structures with high resolution

Researchers have discovered a groundbreaking use of terahertz (THz) imaging to visualize cochlear structures in mice, offering non-invasive, high-resolution diagnostics. By creating 3D reconstructions, this technology opens new possibilities for diagnosing hearing loss and other conditions.

27 Mar 2025

Study sheds new light on the mechanisms underlying head and neck cancer metastasis

A recent study published in Engineering has shed new light on the mechanisms underlying the metastasis of head and neck squamous cell carcinoma (HNSCC). The research identified enolase 2 (ENO2), a crucial glycolytic enzyme, as a significant factor associated with lymphatic metastasis in HNSCC.

27 Mar 2025

Inhibition of tumor xenograft growth in mice without systemic toxicity

The management of breast cancer involves various therapeutic approaches. However, many current anticancer treatments indiscriminately damage both cancerous and healthy cells. In cancer treatment, Streptomycetes have already been proven as the main resources producing anti-cancer drugs. Streptomyces coelicolor is a representative of the genus Streptomyces.

27 Mar 2025

Targeting PCSK9 and APOA4 for the treatment of TMAO-induced cholelithiasis

Cholesterol synthesis and gallstone formation are promoted by trimethylamine-N-oxide (TMAO), a derivative of trimethylamine, which is a metabolite of gut microbiota.

25 Mar 2025

Researchers develop tool to enhance NK cells against cancer

A team of researchers from the Hospital del Mar Research Institute, the Universitat Autònoma de Barcelona and the Pompeu Fabra University has developed a new tool that allows modifying these NK cells to make them immune to the tumor’s defense mechanism.

24 Mar 2025

Natural compounds identified as potential inhibitors of SARS-CoV-2 spike protein

The COVID-19 pandemic highlighted the urgent need for effective therapeutic agents against SARS-CoV-2.

20 Mar 2025

New enzyme target could lead to breakthrough therapies for Lyme disease

Researchers have discovered that an enzyme can serve as an ideal target for developing new therapeutics against Lyme disease, and most likely other tick-borne diseases as well.

20 Mar 2025

$1 million CPRIT grant focuses on AI to improve prostate cancer outcomes

Erzsébet Merényi, a statistics research professor at Rice University, and co-investigators at The University of Texas MD Anderson Cancer Center Pratip Bhattacharya, professor of cancer systems imaging, and Dr. Patrick Pilié, assistant professor of genitourinary medical oncology, were awarded $1 million by the Cancer Prevention and Research Institute of Texas (CPRIT) to develop artificial intelligence (AI) tools that can identify lethal forms of prostate cancer earlier and improve treatment selection.

18 Mar 2025

FDA-approved drug for chronic kidney disease may help mitigate antibiotic resistance

Increased antibiotic use can lead, seemingly paradoxically, to more problematic infections, as the bacteria evolve to resist the treatment.

18 Mar 2025

Insights into drug absorption and predictive modeling with Professor Kiyohiko Sugano

Learn how drug absorption and predictive modeling drive advancements in pharmaceuticals and precision medicine.

From Pion Inc 18 Mar 2025

NKD2 protein discovery opens up new possibilities in the fight against bone loss

A transformative study has uncovered the pivotal role of the protein Naked cuticle homolog 2 (NKD2) in regulating the differentiation of bone-forming osteoblasts and bone-resorbing osteoclasts.

17 Mar 2025

Novel cyclic peptide antagonist can be a promising therapeutic approach for MASH

The farnesoid X receptor (FXR) is a bile acid nuclear receptor that plays a crucial role in regulating bile acid and sterol metabolism.

14 Mar 2025

Breakthrough peptide inhibitor effective against multiple SARS-CoV-2 variants

SARS-CoV-2, the virus responsible for COVID-19, infects cells by binding its spike protein to angiotensin-converting enzyme 2 (ACE2) receptors.

14 Mar 2025

Engineered nano-aircraft carrier enhances tumor targeting and immune response

The researchers designed an efficient approach for fabricating engineered Pts-based nano-aircraft carriers with graded drug delivery and ECM degradation for precise cancer chemoimmunotherapy.

14 Mar 2025

Study uncovers new insights into pain pathways linked with temporomandibular joint disorders

A groundbreaking study has uncovered new insights into the pain pathways associated with temporomandibular joint (TMJ) disorders.

13 Mar 2025

CRISPR technologies paving the way for advances in regenerative medicine

A recent review published in the journal Engineering delves into the significant advancements and potential of CRISPR technologies in the field of regenerative medicine.

13 Mar 2025

Is fluoride safe for your gut? New study investigates

Systematic review finds that while low-dose fluoride has little effect on gut microbiota, high doses disrupt microbial diversity and balance, especially in animal studies. The effects vary by species, fluoride form, and exposure level, raising concerns about high-dose fluoride impacts on gut health.

11 Mar 2025

New automated system revolutionizes drug evaluation in zebrafish

Preclinical drug evaluation, especially for cardiotoxicity, is a critical stage in the drug development process.

11 Mar 2025

Can microbiome discoveries finally become treatments? Scientists show the way

Researchers propose a novel iterative strategy combining big data and experimental models to move microbiome research from theory to clinical applications. The study highlights the need to bridge the gap between correlation and causation to develop effective microbiome-based therapies.

9 Mar 2025

Long-term NSAID use may lower dementia risk

Long-term NSAID use reduces dementia risk, particularly in those without the APOE-ε4 gene, highlighting the importance of sustained anti-inflammatory treatment over dosage levels.

9 Mar 2025

in vivo News and Research

Terahertz imaging reveals cochlear structures with high resolution

Study sheds new light on the mechanisms underlying head and neck cancer metastasis

Inhibition of tumor xenograft growth in mice without systemic toxicity

Targeting PCSK9 and APOA4 for the treatment of TMAO-induced cholelithiasis

Researchers develop tool to enhance NK cells against cancer

Natural compounds identified as potential inhibitors of SARS-CoV-2 spike protein

New enzyme target could lead to breakthrough therapies for Lyme disease

$1 million CPRIT grant focuses on AI to improve prostate cancer outcomes

FDA-approved drug for chronic kidney disease may help mitigate antibiotic resistance

Insights into drug absorption and predictive modeling with Professor Kiyohiko Sugano

NKD2 protein discovery opens up new possibilities in the fight against bone loss

Novel cyclic peptide antagonist can be a promising therapeutic approach for MASH

Breakthrough peptide inhibitor effective against multiple SARS-CoV-2 variants

Engineered nano-aircraft carrier enhances tumor targeting and immune response

Study uncovers new insights into pain pathways linked with temporomandibular joint disorders

CRISPR technologies paving the way for advances in regenerative medicine

Is fluoride safe for your gut? New study investigates

New automated system revolutionizes drug evaluation in zebrafish

Can microbiome discoveries finally become treatments? Scientists show the way

Long-term NSAID use may lower dementia risk

Human iPSCs: A Full Guide to Advanced in Vitro Models and Applications eBook

Lab Matters host Harriet Gould on building a more connected lab community

The Critical Role of Sample Storage in Drug Discovery and Development

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

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