Clinical Trial News and Research

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Neuromuscular training in cardiac rehabilitation improves quality of life in heart attack patients

Neuromuscular training improves balance, stability, coordination and reaction speed, increasing patients’ ability to perform daily chores and allowing them to gain quality of life.

5 Feb 2021

Scripps Research collaborates with Tempus to develop a predictive model of glucose responses

Scripps Research, a globally recognized nonprofit biomedical research institute, today announced a collaborative research program with Tempus, a leader in precision medicine and artificial intelligence, to develop a predictive model of glucose responses in people with and without type 2 diabetes.

4 Feb 2021

Pharmacologist lays out a plan to improve the equity of drug development

In a new perspective piece published in the Feb. 5 issue of Science, pharmacologist Namandje Bumpus, Ph.D. -- who recently became the first African American woman to head a Johns Hopkins University School of Medicine department, and is the only African American woman leading a pharmacology department in the country -- outlines the molecular origins for differences in how well certain drugs work among distinct populations.

4 Feb 2021

Phase I/II trial findings support use of CoronaVac vaccine in older individuals

Researchers in China have reported phase I/II clinical trial findings showing that the vaccine candidate CoronaVac is well tolerated among older individuals and effectively generates antibody responses against severe acute respiratory syndrome coronavirus 2 (SARs-CoV-2) - the agent that causes coronavirus disease 2019 (COVID-19).

4 Feb 2021

New drug candidate to be trialed for most lethal form of brain cancer

A new drug candidate has been discovered by the University of South Australia to treat the most lethal form of brain cancer - glioblastoma - which kills 95 per cent of patients within five years.

4 Feb 2021

South African SARS-CoV-2 variant neutralized by two Chinese vaccines in case study

A new study offers some reassuring findings, reporting the successful neutralization of the South African SARS-CoV-2 variant of concern (VOC) 501Y.V2 by two vaccines developed in China.

4 Feb 2021

Russia's Sputnik V COVID-19 shown to have 91.6 percent efficacy

The phase 3 human trial is the last stage of clinical evaluation, showing how effective and safe a drug or vaccine is. In this case, the Gam- Sputnik V showed a consistent strong protective effect across all participant age groups.

3 Feb 2021

Nasodine antiseptic nasal spray shows potential antiviral activity against SARS-CoV-2

A team of international scientists has recently investigated the efficacy of PVP-1, a complex of polyvinylpyrrolidone and iodine, in preventing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Using in vitro cell culture settings, the scientists observe that PVP-1 formulation used in a commercially available nasal spray (Nasodine) readily inactivates SARS-CoV-2 within a short period of time.

3 Feb 2021

Spark Therapeutics launches gene therapy clinical trial for late-onset Pompe disease

Pompe disease is a hereditary genetic disorder caused by a deficiency of acid alpha-glucosidase leading to build-up of glycogen in the lyosomes, which then causes cell damage in various tissues, in particular the heart, the muscles, the liver and the nervous system.

3 Feb 2021

Early use of therapeutic anticoagulation does not improve survival of critically ill COVID-19 patients

Although abnormal blood clotting has been identified as one of the primary causes of death from COVID-19, early treatment in an intensive care unit (ICU) with therapeutic anticoagulation (anti-clotting) for adults who are critically ill with COVID-19 does not appear to improve chances of survival, and could do more harm than good by increasing the risk for major bleeding, a multicenter research group cautions.

3 Feb 2021

Phase 1 clinical trial of novel HIV vaccine approach shows promising results

A phase 1 clinical trial testing a novel vaccine approach to prevent HIV has produced promising results, IAVI and Scripps Research announced today.

3 Feb 2021

Latest clinical trial supports UK’s decision to delay second COVID vaccine dose

Researchers in the UK, South Africa and Brazil have reported the latest efficacy results from phase III trials of the Oxford–AstraZeneca vaccine currently being rolled out in the UK to protect against coronavirus disease 2019 (COVID-19).

3 Feb 2021

Canadian Neuromuscular Disease Registry increases patient access to research, clinical trials

The Canadian Neuromuscular Disease Registry (CNDR) was launched in 2010 to increase efficient patient access to cutting-edge research and clinical trials, to increase understanding of the natural history and epidemiology of neuromuscular disease across Canada, and to facilitate research collaboration.

3 Feb 2021

New technology uses near-infrared imaging and machine learning to find hidden tumors

Tumors can be damaging to surrounding blood vessels and tissues even if they're benign. If they're malignant, they're aggressive and sneaky, and often irrevocably damaging. In the latter case, early detection is key to treatment and recovery.

3 Feb 2021

Gene mutations may explain the poorer outcomes in Hispanic and Latino children with leukemia

A combination of genetic mutations may explain the higher incidence of and poorer outcomes from pediatric leukemia in Hispanic and Latino children, according to Penn State College of Medicine researchers.

2 Feb 2021

Study shows safety and effectiveness of two recommended ICU sedatives

Sedative medications used in intensive care are associated with increased delirium, which is in turn connected with higher medical costs and greater risk of death and ICU-related dementia.

2 Feb 2021

Prostate drug may have potential to prevent or delay the development of Parkinson's disease

Taking a particular type of medication to treat enlarged prostate is associated with a reduced risk of developing Parkinson's disease, according to a large observational study led by researchers at the University of Iowa, with colleagues in Denmark and China.

1 Feb 2021

Groundbreaking therapy may provide a new treatment modality for biofilm infections in foot ulcers

A new £1.7m project to explore using plasma jets and antimicrobial dressings to treat debilitating - and potentially deadly - wound infections launches today.

1 Feb 2021

India's Covaxin vaccine likely effective against UK SARS-CoV-2 variant: Study

A new preprint research paper, posted to the preprint server bioRxiv, presents data indicating that the Indian-made Covaxin vaccine candidate successfully neutralizes this variant, preventing infection when challenged by it.

1 Feb 2021

Phase III study of (m)RNA expression did not confer significant advantage for stage II-III lung cancer

A phase III study examining whether messenger (m)RNA expression correlated with sensitivity or resistance to chemotherapy did not confer a statistically significant advantage in overall survival for patients with resected stage II-III non-small cell lung cancer (NSCLC), according to research presented at the International Association for the Study of Lung Cancer World Conference on Lung Cancer.

31 Jan 2021

Clinical Trial News and Research

Neuromuscular training in cardiac rehabilitation improves quality of life in heart attack patients

Scripps Research collaborates with Tempus to develop a predictive model of glucose responses

Pharmacologist lays out a plan to improve the equity of drug development

Phase I/II trial findings support use of CoronaVac vaccine in older individuals

New drug candidate to be trialed for most lethal form of brain cancer

South African SARS-CoV-2 variant neutralized by two Chinese vaccines in case study

Russia's Sputnik V COVID-19 shown to have 91.6 percent efficacy

Nasodine antiseptic nasal spray shows potential antiviral activity against SARS-CoV-2

Spark Therapeutics launches gene therapy clinical trial for late-onset Pompe disease

Early use of therapeutic anticoagulation does not improve survival of critically ill COVID-19 patients

Phase 1 clinical trial of novel HIV vaccine approach shows promising results

Latest clinical trial supports UK’s decision to delay second COVID vaccine dose

Canadian Neuromuscular Disease Registry increases patient access to research, clinical trials

New technology uses near-infrared imaging and machine learning to find hidden tumors

Gene mutations may explain the poorer outcomes in Hispanic and Latino children with leukemia

Study shows safety and effectiveness of two recommended ICU sedatives

Prostate drug may have potential to prevent or delay the development of Parkinson's disease

Groundbreaking therapy may provide a new treatment modality for biofilm infections in foot ulcers

India's Covaxin vaccine likely effective against UK SARS-CoV-2 variant: Study

Phase III study of (m)RNA expression did not confer significant advantage for stage II-III lung cancer

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