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Study to test new precision medicine approach for metastatic pancreatic cancer

The Lustgarten Foundation has awarded Columbia University's Herbert Irving Comprehensive Cancer Center a three-year grant, as part of its Translational Clinical Program, to test a new precision medicine approach to the treatment of metastatic pancreatic cancer.

18 Jan 2018

Review explores consequences of genetic testing and cancer risk-reducing surgery

Genetic testing is commonplace for many inheritable cancer syndromes, and with that comes the knowledge of being a gene carrier for some patients.

18 Jan 2018

Three-dimensional organization of genome plays key role in gene expression, cell fate

Scientists have long been reading the code of life - the genome -, as a sequence of letters but now researchers have also started exploring its three-dimensional organization.

17 Jan 2018

Scientists identify six new gene regions that may help treat type 1 diabetes

Six novel chromosomal regions identified by scientists leading a large, prospective study of children at risk for type 1 diabetes will enable the discovery of more genes that cause the disease and more targets for treating or even preventing it.

17 Jan 2018

EXD2 enzyme facilitates protein production in mitochondria

Researchers from the Genomic Instability and Cancer Laboratory at Institute for Research in Biomedicine (IRB Barcelona) have identified a key role for EXD2 in protein production in the mitochondria, the cellular organelles responsible for the majority of energy generation.

17 Jan 2018

Fast food triggers the immune system making it hyperactive

The immune system has been shown to react to fast foods containing excess salt and calories find researchers. This activation of the immune system to fast foods is similar to its reaction to bacterial infections they add.

16 Jan 2018

Research sheds new light on genetic, environmental factors that promote prostate cancer metastasis

Prostate tumors tend to be what scientists call "indolent" - so slow-growing and self-contained that many affected men die with prostate cancer, not of it. But for the percentage of men whose prostate tumors metastasize, the disease is invariably fatal.

15 Jan 2018

Past exposures influence immune response in children with acute respiratory tract infections

Acute respiratory tract infections (ARTI) are the leading global cause of death in early childhood, according to the Centers for Disease Control and Prevention.

12 Jan 2018

Discovery suggests new approach for targeting most-wanted molecular culprits in cancer

A discovery by scientists at Dana-Farber Cancer Institute and University of Texas Southwestern Medical Center presents drug developers with an entirely new tack in targeting one of the most-wanted molecular culprits in cancer.

12 Jan 2018

Mount Sinai study uncovers potential link between Crohn's and Parkinson's in Jewish population

Mount Sinai Researchers have just discovered that patients in the Ashkenazi Jewish population with Crohn's disease (a chronic inflammatory of the digestive system) are more likely to carry the LRRK2 gene mutation.

11 Jan 2018

Researchers discover new weapon to combat tuberculosis

Tuberculosis (TB), an infectious disease which attacks the lungs, claims someone's life every 20 seconds and 1.5 million lives worldwide every year.

11 Jan 2018

Study reveals how dengue virus replicates without triggering the body's defenses

A new study reveals how dengue virus manages to reproduce itself in an infected person without triggering the body's normal defenses. Duke researchers report that dengue pulls off this hoax by co-opting a specialized structure within host cells for its own purposes, like a lazy roommate sneaking bits of his laundry into the communal wash.

11 Jan 2018

Unhealthy diet makes the body's defenses more aggressive in the long term

The immune system reacts similarly to a high fat and high-calorie diet as to a bacterial infection. This is shown by a recent study led by the University of Bonn.

11 Jan 2018

New blood stabilization method prolongs lifespan of blood samples for CTC profiling

A new blood stabilization method, developed at the Massachusetts General Hospital Center for Engineering in Medicine, significantly prolongs the lifespan of blood samples for microfluidic sorting and transcriptome profiling of rare circulating tumor cells (CTCs), living cancer cells carried in the bloodstream.

9 Jan 2018

Scientists use artificial intelligence to create new ‘ImmunoMap’

Johns Hopkins scientists have used a form of artificial intelligence to create a map that compares types of cellular receptors, the chemical "antennas" on the surface of immune system T-cells.

8 Jan 2018

Researchers discover mutations in a gene related to obesity

Researchers have discovered mutations in a gene related to obesity, offering new treatment possibilities in the fight against the global epidemic.

8 Jan 2018

Polygenic risk score predicts early-onset heart disease risk

A risk score based on multiple genetic differences, or polygenic risk score, predicted significantly more cases of early-onset heart disease than standard tests for single genetic defects, according to new research in the American Heart Association's journal Circulation: Genomic and Precision Medicine.

8 Jan 2018

Sangamo and Pfizer partner for development of new zinc finger protein gene therapy to treat ALS

Sangamo Therapeutics, Inc. and Pfizer Inc. today announced a collaboration for the development of a potential gene therapy using zinc finger protein transcription factors (ZFP-TFs) to treat amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD) linked to mutations of the C9ORF72 gene.

8 Jan 2018

Researchers use genomic technologies to better understand risk factor for stomach cancer

A research team led by National University Health System and Duke-NUS Medical School has used genomic technologies to better understand intestinal metaplasia, a known risk factor for gastric (stomach) cancer.

5 Jan 2018

Researchers discover genetic mechanism for resistance to immunotherapy drugs

An urgent question for cancer scientists is why immunotherapy achieves dramatic results in some cases but doesn't help most patients.

5 Jan 2018

Genomic News and Research

Study to test new precision medicine approach for metastatic pancreatic cancer

Review explores consequences of genetic testing and cancer risk-reducing surgery

Three-dimensional organization of genome plays key role in gene expression, cell fate

Scientists identify six new gene regions that may help treat type 1 diabetes

EXD2 enzyme facilitates protein production in mitochondria

Fast food triggers the immune system making it hyperactive

Research sheds new light on genetic, environmental factors that promote prostate cancer metastasis

Past exposures influence immune response in children with acute respiratory tract infections

Discovery suggests new approach for targeting most-wanted molecular culprits in cancer

Mount Sinai study uncovers potential link between Crohn's and Parkinson's in Jewish population

Researchers discover new weapon to combat tuberculosis

Study reveals how dengue virus replicates without triggering the body's defenses

Unhealthy diet makes the body's defenses more aggressive in the long term

New blood stabilization method prolongs lifespan of blood samples for CTC profiling

Scientists use artificial intelligence to create new ‘ImmunoMap’

Researchers discover mutations in a gene related to obesity

Polygenic risk score predicts early-onset heart disease risk

Sangamo and Pfizer partner for development of new zinc finger protein gene therapy to treat ALS

Researchers use genomic technologies to better understand risk factor for stomach cancer

Researchers discover genetic mechanism for resistance to immunotherapy drugs

The art of CRISPR: The power and promise of gene editing eBook

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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